Navigation Links
Gene Mutations May Cause Rare Neonatal Diabetes
Date:9/14/2007

Condition requires lifelong dependence on insulin injections, researchers say

FRIDAY, Sept. 14 (HealthDay News) -- Mutations in an insulin-linked gene can cause permanent neonatal diabetes, say American and U.K. researchers.

They have identified 10 such mutations in 21 people from 16 families.

Permanent neonatal diabetes is a rare form of diabetes that affects infants and leads to lifelong dependence on insulin injections. This is the first study to link insulin gene mutations to severe diabetes with onset early in life, the researchers said.

The mutations may influence the way insulin folds during its synthesis. These improperly folded proteins interfere then with other cellular processes in ways that eventually result in the death of cells that produce insulin, the researchers said.

The findings were published online by the journal Proceedings of the National Academy of Sciences and were expected to be in an upcoming print issue.

"This is a novel and potentially treatable cause of diabetes in infants," study author Dr. Louis Philipson, professor of medicine at the University of Chicago, said in a prepared statement.

This research "is exciting, because each of these patients has one normal insulin gene as well as one mutated gene. If we could detect the disease early enough and somehow silence the abnormal gene, or just protect insulin-producing cells from the damage caused by misfolding, we might be able to preserve or restore the patient's own insulin production," Philipson said.

More information

The U.S. National Diabetes Information Clearinghouse has more about neonatal diabetes.



-- Robert Preidt



SOURCE: University of Chicago Medical Center, news release, Sept. 10, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Minor mutations in HIV virus
2. Stem Cells Have Few Mutations
3. Mutations in NOTCH1 cause an early developmental defect in the aortic valve
4. Success of HIV may depend in its mutations
5. BRAC2 mutations is also linked with cancers in men
6. Skin Cancer caused by mutations in a single Gene
7. Developing Countries Undertake Cataloguing of Human Mutations
8. Gene Mutations Causing Rett Syndrome Occur in Both Sexes
9. New Technique Identifies Unknown Genetic Mutations That Can Cause Cancer
10. Uterine cancer may be associated with inherited mutations and a risk of many cancers
11. Scinetists Alert to Onset of Pandemic through Bird flu Mutations to Humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
(Date:9/19/2017)... Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses ... today:   ... Jim ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D and business ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
Breaking Medicine Technology: