Navigation Links
Gene Mutations May Cause Rare Neonatal Diabetes
Date:9/14/2007

Condition requires lifelong dependence on insulin injections, researchers say

FRIDAY, Sept. 14 (HealthDay News) -- Mutations in an insulin-linked gene can cause permanent neonatal diabetes, say American and U.K. researchers.

They have identified 10 such mutations in 21 people from 16 families.

Permanent neonatal diabetes is a rare form of diabetes that affects infants and leads to lifelong dependence on insulin injections. This is the first study to link insulin gene mutations to severe diabetes with onset early in life, the researchers said.

The mutations may influence the way insulin folds during its synthesis. These improperly folded proteins interfere then with other cellular processes in ways that eventually result in the death of cells that produce insulin, the researchers said.

The findings were published online by the journal Proceedings of the National Academy of Sciences and were expected to be in an upcoming print issue.

"This is a novel and potentially treatable cause of diabetes in infants," study author Dr. Louis Philipson, professor of medicine at the University of Chicago, said in a prepared statement.

This research "is exciting, because each of these patients has one normal insulin gene as well as one mutated gene. If we could detect the disease early enough and somehow silence the abnormal gene, or just protect insulin-producing cells from the damage caused by misfolding, we might be able to preserve or restore the patient's own insulin production," Philipson said.

More information

The U.S. National Diabetes Information Clearinghouse has more about neonatal diabetes.



-- Robert Preidt



SOURCE: University of Chicago Medical Center, news release, Sept. 10, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Minor mutations in HIV virus
2. Stem Cells Have Few Mutations
3. Mutations in NOTCH1 cause an early developmental defect in the aortic valve
4. Success of HIV may depend in its mutations
5. BRAC2 mutations is also linked with cancers in men
6. Skin Cancer caused by mutations in a single Gene
7. Developing Countries Undertake Cataloguing of Human Mutations
8. Gene Mutations Causing Rett Syndrome Occur in Both Sexes
9. New Technique Identifies Unknown Genetic Mutations That Can Cause Cancer
10. Uterine cancer may be associated with inherited mutations and a risk of many cancers
11. Scinetists Alert to Onset of Pandemic through Bird flu Mutations to Humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... IsoComforter, Inc. ( ... announced today the introduction of an innovative new design of the shoulder pad. ... you get maximum comfort while controlling your pain while using cold therapy. By utilizing ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
(Date:10/12/2017)... GRAND RAPIDS, Mich. (PRWEB) , ... October 12, ... ... OnSite Wellness, has been named one of Michigan’s 2017 Best and Brightest in ... Best and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  Caris Life Sciences ® , ... the promise of precision medicine, today announced that St. ... Precision Oncology Alliance™ (POA) as its 17 th ... St. Jude Crosson Cancer Institute will help develop standards ... of tumor profiling, making cancer treatment more precise and ...
(Date:10/7/2017)... Texas , Oct. 6, 2017   Provista, ... with more than $100 billion in purchasing power, today ... news and information. The Newsroom is the ... and industry trends, infographics, expert bios, news releases, slideshows ... having access to a wealth of resources at their ...
(Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
Breaking Medicine Technology: