Navigation Links
Gene Mutations May Blunt Plavix's Effectiveness, Study Finds
Date:10/26/2010

By Steven Reinberg
HealthDay Reporter

TUESDAY, Oct. 26 (HealthDay News) -- People with certain gene variants who take the blood-thinning drug Plavix (clopidogrel) may be at increased risk for serious complications after coronary stent placement, a new study finds.

Having the gene variants seems to reduce the effectiveness of Plavix and put patients at higher risk of developing blood clots in the stent, suffering a heart attack or stroke, or even dying, according to the research.

"Clopidogrel is one of the most commonly prescribed medications worldwide," said lead researcher Dr. Jessica L. Mega, an instructor in medicine at Brigham and Women's Hospital and Harvard Medical School in Boston.

But, "not all patients experience the same anti-clotting effects of the medication. Some of this variation is based on genetic variants in the CYP2C19 gene," she said.

For the study, published in the Oct. 27 issue of the Journal of the American Medical Association, Mega's team conducted a meta-analysis of nine studies involving a total of 9,685 people. In a meta-analysis, researchers review published studies to tease out data about particular outcomes.

In this case, the researchers looked for the effect that variants of the CYP2C19 gene had on people taking the antiplatelet drug and undergoing angioplasty and stent placement to open a blocked artery.

Among the patients studied, 863 died or had a heart attack or stroke, and 84 developed blood clots in their stents.

The researchers found that 71.5 percent of the total patient group had no variant of the CYP2C19 gene. However, 26.3 percent had one variant and 2.2 percent had two variants of the CYP2C19 gene that appeared to affect the body's response to Plavix.

Having one or two variants significantly increased the risk of death, heart attack or stroke, or developing blood clots in the stents, the researchers found.

Plavix uses a liver
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
2. Study shows that mutations in 1 gene cause many cancers
3. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
6. Single Lung Tumor Contains 50,000 Mutations
7. Gene Mutations Offer Clues to Autoimmune Disorders
8. Individual mutations are very slow to promote tumor growth
9. Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
10. Emotions May Be Blunted in Alzheimers Patients
11. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations May Blunt Plavix's Effectiveness, Study Finds
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... 22, 2015 A study recently ... flagship journal Medicine & Science in Sports & ... may help reduce gastrointestinal (GI) problems associated with ... Participants in the double-blind, placebo-controlled study took 10 ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
(Date:1/22/2015)... Colorado (PRWEB) January 22, 2015 Four years since ... Queen – which coincided with the marriage of Avasa & Matthew ... THE ROAD, which is scheduled for release through White Swan Records ... message that there is a sacred path available to all of ...
(Date:1/22/2015)... January 22, 2015 EBSCO Information Services ... are expanding their relationship in an effort to further promote ... world. While EBSCO has long made AMA journals available via ... agent for The JAMA Network. , Long known ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... conducted by Asher Chanan-Khan, MD, Department of Medicine, Roswell ... relapsed chronic lymphocytic leukemia (CLL) or diseases that no ... to the therapy. The results of this study were ... of Clinical Oncology. ,"Chronic lymphocytic leukemia ...
... by U.S firm Schwarz has found to be potential in ... other drugs - the company said on Monday following the ... of the 485-patient study were presented at the North American ... a 200-mg dose of the drug, lacosamide, had 14.4 percent ...
... A new study has challenged the ill-effects of obesity, as ... that being overweight// is a major risk factor for cancer, ... may help in protecting younger women from breast cancer. ... Mass Index results in reduced levels of female hormones, the ...
... the Insecticides Act, 1968 registers pesticides only after satisfying ... data generated under supervised trials is analyzed and used ... of Health & Family Welfare under the Prevention of ... inspection of fruits and vegetables for the presence of ...
... Denis Broun, UNAIDS India coordinator, explained how India’s legal stance ... against HIV/AIDS and is an// infringement of the human rights ... mainly to bring offenders to book, in cases dealing with ... the law is annulled, it may cause a setback to ...
... heart attack Sunday and was taken to a military hospital, ... Pinochet's condition as "serious but stable". ,It said ... were also affected. ,On Nov 25, Pinochet, who ... of supporters gathering outside his home here to congratulate him. ...
Cached Medicine News:
(Date:1/23/2015)... plc (NYSE: MNK ) announced today that ... program. The open-ended authorization permits the company to repurchase ... "Funding additional initiatives and seeking attractive ... to pursue a range of focused growth strategies," said ...
(Date:1/22/2015)... CLEVELAND , Jan. 22, 2015  ViewRay™, a privately ... entered into an exclusive distributor agreement with ITOCHU Corporation ... radiation therapy system for the treatment of cancer in ... (me-rid-i-an) system, is the world,s first and only MRI-guided ...
(Date:1/22/2015)... 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or ... Omega-3 therapies for cardiovascular disease and overall health is pleased ... in 2014 and its outlook for 2015 from the CEO, ... We would like to take this opportunity to ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... 2011 The New Jersey Patient Care and Access Coalition ... encourages men and their families to speak out to preserve ... Force (USPSTF) recommended healthy men should no longer receive prostate-specific ... This decision was made by a panel ...
... 2011 Masimo (NASDAQ: ... Japanese Ministry of Health Labor & Welfare (MHLW) ... rainbow® Acoustic Monitoring technology—providing noninvasive and continuous acoustic ... and enhance patient compliance.  Available for the first ...
Cached Medicine Technology:NJ Docs Say Cancer Detection Tool Saves Lives 2Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 2Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 3Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 4Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 5Masimo rainbow Acoustic Monitoring Technology Cleared for Market in Japan 6
Agility has delivered a RFID-enabled mobile asset management program....
... can provide RFID-enabled tracking and ... medical and surgical supplies. AgileTrac ... track tote deliveries to patient ... track and manage inventories of ...
... RoamAlert Integrity system builds on the ... door controllers in the system are ... a standard Windows® operating system, which ... of a personal computer, RoamAlert Integrity ...
... enterprise visibility solution that allows hospitals ... and increase patient satisfaction. Awarix ... and geospatial visual technologies with your ... real time patient care model that ...
Medicine Products: