Navigation Links
Gene Mutations Linked to Thyroid Cancer Risk: Study
Date:1/1/2012

FRIDAY, Dec. 30 (HealthDay News) -- Researchers have identified three gene abnormalities that appear to raise the likelihood for developing the thyroid cancer, with one in particular -- the PTEN gene -- implicated in children's risk for the disease.

Dr. Charis Eng, founding director of the Genomic Medicine Institute of Cleveland Clinic's Lerner Research Institute, said in a news release that her team's "investigation into the genetics behind thyroid disease raises important details relevant to diagnosis and treatment. We hope to promote the earliest diagnosis and most targeted treatment possible."

The researchers unearthed the gene-cancer risk link by examining and tracking roughly 3,000 patients, many of whom had already been diagnosed with a different disease called Cowden syndrome.

The study, published in the Dec 1. issue of the Journal of Clinical Endocrinology & Metabolism, focused on mutations in three genes: PTEN, SDH and KLLN. Because all work on distinct cell pathways, potential treatments to reduce cancer risk would have to target each gene individually.

Thyroid cancer has experienced the largest increase among both men and women of all cancers, according to the Cleveland Clinic release.

PTEN is a tumor-suppressor gene that, when healthy, aids in cell growth and division. Inherited PTEN mutations, however, impede the gene's normal function while spurring the growth of tumors. These abnormalities are known to be present in about 80 percent of patients with Cowden syndrome, who are considered at risk for developing breast and thyroid cancer.

The investigators concluded that mutations in the PTEN gene were indeed associated with a rise in thyroid cancer risk, with some early indications that mutations in the SDH and KLLN genes might also be implicated.

Children under the age of 18, however, seem to face a unique cancer risk dynamic: While PTEN mutations were seen to elevate thei
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Massive DNA search uncovers new mutations driving blood cancer
2. Panel of melanoma mutations opens door to new treatment possibilities
3. Linking of mutations in 12 genes to ovarian cancer may lead to more effective prevention
4. Newly Found Gene Mutations May Aid Heart Treatments
5. Women With BRCA Mutations Get Cancer Diagnosis Earlier Than Before
6. Women who inherit BRCA gene mutations develop cancer earlier than their ancestors
7. Gene Mutations Identified in Uterine Fibroids
8. ADHD, Autism May Sometimes Share Gene Mutations
9. Elusive gene mutations found for malignant brain tumor
10. Scientists identify order of mutations that lead to cancer
11. Sequence of ovarian genome identifies predominant gene mutations, points to possible treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Linked to Thyroid Cancer Risk: Study
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... further study on meningococcal infection. He suggests that an ... to better understand, and further prevent, the bacterial infection. ... since its introduction in 2003, but the disease incidence ... could do better," Dr Patel said. ,In ...
... affects the bacterial composition of the oral cavity even in ... high intake is needed to counteract the production of acid ... that is produced by reduction of the sugar xylose, or ... as pears and strawberries. It is used in sugarless sweets, ...
... morbidity rate in the Indian capital is 17 per thousand ... government study said Thursday. ,The report - Morbidity, ... by the directorate of economics and statistics of the state ... the lowest among all the states. ,"The morbidity ...
... Hopkins brain scientists have found why some powerful drugs ... weight rather than develop complications like diabetes and heart ... of antipsychotics to natural brain chemicals that trigger appetite,” ... the Johns Hopkins School of Medicine. “Our identification of ...
... could not be prouder to announce it will launch ... a fetus with a known birth defect. Set to ... Unit will offer comprehensive medical care, from prenatal diagnosis ... eight-bed labor and delivery unit will allow Children’s Hospital’s ...
... A latest research suggests that human brain can continuously produce ... the treatment of diseases like Alzheimer’s.// This research was undertaken ... the Sahlgrenska Academy in Sweden. ,Stem cells reside ... team observed in human beings that these cells move to ...
Cached Medicine News:Health News:More Research on Meningococcal Infection Called for 2Health News:Xylitol Fights Oral Bacteria 2Health News:Delhi's Morbidity Rate Nearly One-sixth of National Average 2Health News:Scientists Uncover Cause of Antipsychotic Drug Weight Gain 2Health News:Special Delivery Unit for Pregnant Moms With Birth Defects in Fetus 2
(Date:12/24/2014)... , Dec. 24, 2014  Conkwest, Inc., the ... the proprietary Natural Killer (NK) cell-line platform, Neukoplast® ... Patrick Soon-Shiong , NantWorks founder, physician scientist ... agreement to purchase approximately $48 million of the ... the investment, he will be named Co-Chairman of ...
(Date:12/24/2014)... YORK and LONDON , ... global orthopedic industry are expected to grow at an ... in terms of value and volume. Hip, knee and ... developed world while in emerging economies they have a ... rates are challenging the use of composites. Non-metallic orthopedic ...
(Date:12/24/2014)... 2014  Advanced Medical Isotope Corporation ("AMIC") (OTCQB: ADMD), ... the development of brachytherapy devices and medical isotopes ... it has filed a de novo ... for marketing clearance for its patented Y-90 RadioGel(TM) ... Food, Drug and Cosmetic Act (the "Act").  ...
Breaking Medicine Technology:Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3
CCR Medical conventional laryngoscope handles....
... Wire-Reinforced LMA ™ Airway., ,The ... tube which allows it to be ... while maintaining a good seal. This ... and dental surgery, or other procedures ...
... Airway. , ,Developed for cardiopulmonary resuscitation ... the LMA Fastrach™ has been designed to ... or neck. The LMA Fastrach™ allows continuous ... by emergency teams worldwide including NASA for ...
... in the production of airway ... an integrated solution to all ... single-use Portex Soft Seal Laryngeal ... to this wide portfolio of ...
Medicine Products: