Navigation Links
Gene Mutations Linked to Thyroid Cancer Risk: Study
Date:1/1/2012

FRIDAY, Dec. 30 (HealthDay News) -- Researchers have identified three gene abnormalities that appear to raise the likelihood for developing the thyroid cancer, with one in particular -- the PTEN gene -- implicated in children's risk for the disease.

Dr. Charis Eng, founding director of the Genomic Medicine Institute of Cleveland Clinic's Lerner Research Institute, said in a news release that her team's "investigation into the genetics behind thyroid disease raises important details relevant to diagnosis and treatment. We hope to promote the earliest diagnosis and most targeted treatment possible."

The researchers unearthed the gene-cancer risk link by examining and tracking roughly 3,000 patients, many of whom had already been diagnosed with a different disease called Cowden syndrome.

The study, published in the Dec 1. issue of the Journal of Clinical Endocrinology & Metabolism, focused on mutations in three genes: PTEN, SDH and KLLN. Because all work on distinct cell pathways, potential treatments to reduce cancer risk would have to target each gene individually.

Thyroid cancer has experienced the largest increase among both men and women of all cancers, according to the Cleveland Clinic release.

PTEN is a tumor-suppressor gene that, when healthy, aids in cell growth and division. Inherited PTEN mutations, however, impede the gene's normal function while spurring the growth of tumors. These abnormalities are known to be present in about 80 percent of patients with Cowden syndrome, who are considered at risk for developing breast and thyroid cancer.

The investigators concluded that mutations in the PTEN gene were indeed associated with a rise in thyroid cancer risk, with some early indications that mutations in the SDH and KLLN genes might also be implicated.

Children under the age of 18, however, seem to face a unique cancer risk dynamic: While PTEN mutations were seen to elevate their risk for thyroid cancer, SDH and KLLN abnormalities did not.

PTEN testing is already a staple in the world of genetic screening, the release noted.

More information

For more on thyroid cancer, visit the U.S. National Library of Medicine.

-- Alan Mozes

SOURCE: Journal of Clinical Endocrinology & Metabolism, news release, Dec. 23, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Massive DNA search uncovers new mutations driving blood cancer
2. Panel of melanoma mutations opens door to new treatment possibilities
3. Linking of mutations in 12 genes to ovarian cancer may lead to more effective prevention
4. Newly Found Gene Mutations May Aid Heart Treatments
5. Women With BRCA Mutations Get Cancer Diagnosis Earlier Than Before
6. Women who inherit BRCA gene mutations develop cancer earlier than their ancestors
7. Gene Mutations Identified in Uterine Fibroids
8. ADHD, Autism May Sometimes Share Gene Mutations
9. Elusive gene mutations found for malignant brain tumor
10. Scientists identify order of mutations that lead to cancer
11. Sequence of ovarian genome identifies predominant gene mutations, points to possible treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Linked to Thyroid Cancer Risk: Study
(Date:2/28/2017)... Los Angeles, CA (PRWEB) , ... February 28, 2017 , ... ... prostate cancer and vasectomies. In studying approximately 800 deaths from prostate cancer, the researchers ... prostate cancer and 20% more likely to get fatal prostate cancer. Although the increased ...
(Date:2/28/2017)... ... February 28, 2017 , ... TruClinic Inc. ... intelligence company based in New York. , “Ensuring an intuitive, user-friendly patient experience ... unaltered. Those two fundamental reasons are the reasons this acquisition is an obvious ...
(Date:2/28/2017)... ... February 28, 2017 , ... ... 2017, from 4:30-5:30 p.m. at the 11th Annual RISE Nashville Summit. RISE Nashville ... compliance, performance analytics, and engagement strategies. , The discussion will include best practices ...
(Date:2/27/2017)... ... February 27, 2017 , ... Hotze Health ... announces Chris Brandl as its New Guest Director. , Brandl is a ... throughout his career. He began his professional career at Omnium Worldwide, now known ...
(Date:2/27/2017)... PORT RICHEY, Fla. (PRWEB) , ... February 27, 2017 , ... ... use disorder, but concern for women who become dependent on opioid painkillers has fallen ... among female patients, compared to a 237% increase in fatal overdoses in male populations.(1) ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... -- Halyard Health, Inc. (NYSE: HYH ) today ... 2017 outlook and related key planning assumptions. Executive Summary ... 2 percent increase compared to the prior year. ... million compared to net income of $15 million in the ... $24 million compared to adjusted net income of $27 million ...
(Date:2/27/2017)... , Feb. 27, 2017 Mederi Therapeutics ... 28 studies, representing 2468 patients who received  Stretta ... study entitled, " Systematic Review and Meta-Analysis of ... Radiofrequency for Treatment of Gastroesophageal Reflux Disease ", was ... Ronnie Fass , MD, head of the ...
(Date:2/27/2017)... AMSTERDAM , Feb. 27, 2017   ... AEX: PHIA), a global leader in health technology, ... and Drug Administration (FDA) to market its ElastQ ... EPIQ family of ultrasound systems. ElastQ Imaging enables ... stiffness, which is essential for the diagnosis of ...
Breaking Medicine Technology: