Navigation Links
Gene Mutations Identified in Uterine Fibroids
Date:8/26/2011

FRIDAY, Aug. 26 (HealthDay News) -- Scientists report an advance in the genetics of uterine fibroids, the most common noncancerous tumors in women of childbearing age.

Uterine fibroids, which can cause abnormal bleeding, abdominal pain and discomfort, occur in 60 percent of women by the age 45. Fibroids are also a major cause of infertility and the most common reason for hysterectomy.

Despite their importance, little has been known about what causes these tumors to develop.

In this study, researchers at the University of Helsinki in Finland examined the genetics of 18 fibroid tumors and found that as many as 70 percent of them had specific mutations in a gene called MED12.

The gene produces the MED12 protein, which is known to play a role in regulation of general "gene transcription." The researchers said the pattern of mutations identified in this study suggests that MED12's function is disrupted in a specific way in most fibroid tumors.

The finding that so many fibroid tumors have these specific mutations suggests that it may be possible to develop targeted therapies, but that's likely to take a long time, the study authors said.

"This is a giant step towards understanding why fibroids arise, but towards design of targeted therapies it is a very early step. Let's hope that this journey has begun," research team leader Lauri Aaltonen said in a university news release.

The study was published in the Aug. 25 online edition of the journal Science.

More information

The U.S. National Institute of Child Health and Human Development has more about uterine fibroids.

-- Robert Preidt

SOURCE: University of Helsinki, news release, Aug. 25, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
2. Study shows that mutations in 1 gene cause many cancers
3. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
6. Single Lung Tumor Contains 50,000 Mutations
7. Gene Mutations Offer Clues to Autoimmune Disorders
8. Individual mutations are very slow to promote tumor growth
9. Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
10. Gene Mutations May Blunt Plavixs Effectiveness, Study Finds
11. Unexpectedly small effects of mutations in bacteria bring new perspectives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Identified in Uterine Fibroids
(Date:1/22/2015)... 2015 Deer Path of Huntley -- ... Day Happy Hour from 3 p.m. to 4 p.m. on Feb. ... in Huntley, Illinois, serves adults with physical disabilities between the ages ... Valentine's Day treats, games and sweetheart-themed karaoke. , For more information ...
(Date:1/22/2015)... Liberty University has received accreditation for its resident ... Council for Accreditation of Counseling & Related Educational Programs ... Counseling & Family Studies , is under the leadership of ... of Behavioral Sciences. Prior to the formation of the new ...
(Date:1/22/2015)... 22, 2015 The City of West Hollywood hosted ... to commemorate the 42nd anniversary of the Supreme Court decision Roe ... been 42 years since the Roe vs. Wade decision and the ... present as ever,” said City of West Hollywood Councilmember Abbe Land. ...
(Date:1/22/2015)... TN (PRWEB) January 22, 2015 Gabe’s Chemo Duck ... Duck App, the first app ever created for kids with cancer. ... Apple phones and devices, is filled with enjoyable games to help ... and treatments. The free app helps to keep kids entertained, educated ...
(Date:1/22/2015)... is a seasoned and trusted leader who consistently delivers trendy ... have it lead the wedding dress industry into the future. ... for the global market. , “The CEO of VogueQueen is ... on continuing the goal of operational excellence and giving back ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2
... A study by researchers at UC Davis has found that ... to produce autoantibodies to the brains of their developing fetuses ... risk of later being diagnosed with autism. The finding ... in the development of the neurodevelopmental disorder among some children ...
... Canadian Journal of Cardiology ( www.onlinecjc.ca ) ... imaging methods. This study is important for patients worried ... heart. X-ray based methods have greatly improved the diagnosis ... of radiation exposure. New imaging methods offer ...
... Serena Gordon HealthDay Reporter , TUESDAY, Oct. ... the way that parts of kidney dialysis machines are ... A recently developed sterilization method called electron ... platelets in the blood of dialysis patients, according to ...
... online Oct. 18 in the Journal of the National ... the idea that the immune system,s response to allergies may ... with somewhat elevated blood levels of immunoglobulin E (IgE), antibodies ... significantly less likely to develop gliomas, and those who did ...
... Ind. -- A new study by researchers at Indiana University ... men surprisingly diverse, suggesting that a broader, less disease-focused perspective ... addressing the sexual health of gay and bisexual men. ... Journal of Sexual Medicine, tapped the largest sample ...
... population will nearly double by 2050, according to a ... exists as to who will care for them as ... but those caregiving roles are becoming blurred as more ... previous decades. Now, University of Missouri researchers have found ...
Cached Medicine News:Health News:Genetic variant and autoantibodies linked to having a child with autism 2Health News:Genetic variant and autoantibodies linked to having a child with autism 3Health News:Genetic variant and autoantibodies linked to having a child with autism 4Health News:Study Links New Dialysis Technology to Rise in Bleeding Risk 2Health News:Study Links New Dialysis Technology to Rise in Bleeding Risk 3Health News:More evidence that allergies may help in fighting brain tumors 2Health News:New study finds gay and bisexual men have varied sexual repertoires 2Health News:New study finds gay and bisexual men have varied sexual repertoires 3Health News:Relationships more important than genetic ties when deciding who cares for aging family, study finds 2
(Date:1/23/2015)... (NYSE: MNK ) announced today that its ... The open-ended authorization permits the company to repurchase up ... "Funding additional initiatives and seeking attractive business ... pursue a range of focused growth strategies," said ...
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
(Date:1/22/2015)... , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; ... a focus on Omega-3 therapies for cardiovascular disease and overall ... the Company,s accomplishments in 2014 and its outlook for 2015 ... Dear Fellow Shareholders, We would like to take ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... U.S. Food and Drug Administration has scheduled its fourth ... those unfamiliar with the process for Feb. 28 – ... Keck Graduate Institute. (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... Organization of Rare Disorders and the Genetic Alliance, will ...
... /PRNewswire-Asia/ -- China Sky One Medical, Inc. ("China ... CSKI ), a leading fully integrated pharmaceutical ... today announced that Heilongjiang Tianlong Pharmaceutical, Inc. ("Tianlong"), ... a "Top Ten Branded Company Trusted by Consumers" ...
Cached Medicine Technology:Fourth FDA Orphan Drug Designation Workshop Scheduled for Feb. 28 - March 1, 2011 2China Sky One Medical Receives Medical Industry Awards 2China Sky One Medical Receives Medical Industry Awards 3
Unipolar Atrial "J" Lead...
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
Medicine Products: