Navigation Links
Gene Mutations Identified in Uterine Fibroids
Date:8/26/2011

FRIDAY, Aug. 26 (HealthDay News) -- Scientists report an advance in the genetics of uterine fibroids, the most common noncancerous tumors in women of childbearing age.

Uterine fibroids, which can cause abnormal bleeding, abdominal pain and discomfort, occur in 60 percent of women by the age 45. Fibroids are also a major cause of infertility and the most common reason for hysterectomy.

Despite their importance, little has been known about what causes these tumors to develop.

In this study, researchers at the University of Helsinki in Finland examined the genetics of 18 fibroid tumors and found that as many as 70 percent of them had specific mutations in a gene called MED12.

The gene produces the MED12 protein, which is known to play a role in regulation of general "gene transcription." The researchers said the pattern of mutations identified in this study suggests that MED12's function is disrupted in a specific way in most fibroid tumors.

The finding that so many fibroid tumors have these specific mutations suggests that it may be possible to develop targeted therapies, but that's likely to take a long time, the study authors said.

"This is a giant step towards understanding why fibroids arise, but towards design of targeted therapies it is a very early step. Let's hope that this journey has begun," research team leader Lauri Aaltonen said in a university news release.

The study was published in the Aug. 25 online edition of the journal Science.

More information

The U.S. National Institute of Child Health and Human Development has more about uterine fibroids.

-- Robert Preidt

SOURCE: University of Helsinki, news release, Aug. 25, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
2. Study shows that mutations in 1 gene cause many cancers
3. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
6. Single Lung Tumor Contains 50,000 Mutations
7. Gene Mutations Offer Clues to Autoimmune Disorders
8. Individual mutations are very slow to promote tumor growth
9. Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
10. Gene Mutations May Blunt Plavixs Effectiveness, Study Finds
11. Unexpectedly small effects of mutations in bacteria bring new perspectives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Identified in Uterine Fibroids
(Date:10/13/2017)... (PRWEB) , ... October 13, ... ... School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, ... professionals on guideline updates for the primary prevention of cardiovascular diseases during ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional women, ... towards gender equality at their inaugural Summit in New York City in June. The ... social audience of over 3 million. To watch the Mobilize Women video, click ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... 2017   Provista, a proven leader in ... in purchasing power, today announced a new resource area ... Newsroom is the online home for case studies, ... bios, news releases, slideshows and events. ... of resources at their fingertips, viewers can also watch ...
(Date:10/4/2017)... 4, 2017 OBP Medical , ... medical devices, today announced regulatory approval from ... (or Agência Nacional de Vigilância Sanitária (ANVISA)) to ... surgical retractor with integrated LED light source and ... and exposure of a tissue pocket or cavity ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
Breaking Medicine Technology: