Navigation Links
Gene Mutation's Benefit for Ovarian Cancer Patients May Not Last: Study
Date:2/19/2013

TUESDAY, Feb. 19 (HealthDay News) -- Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study.

"Of those women diagnosed with invasive ovarian cancer in the United States and Canada, approximately 35 percent are expected to be long-term survivors and ultimately cured," Thomas Sellers, director of the Moffitt Cancer Center in Tampa, Fla., said in a center news release. "We sought to estimate the 10-year survival for women with ovarian cancer -- with and without the mutations -- to determine whether or not the observed short-term survival benefit for those with the mutations was associated with a better prospect for cure."

In conducting the study, the researchers examined the long-term survival of more than 1,600 women with a BRCA1 or BRCA2 gene mutation diagnosed with invasive ovarian cancer. The women were followed for up to 15 years.

In the three years after a diagnosis of invasive ovarian cancer, the researchers found a BRCA gene mutation was linked to a better prognosis. For women without a BRCA mutation, the most deaths occurred about two years after they were diagnosed. For mutation carriers, however, the most deaths occurred about 3.5 years after diagnosis. The researchers suggested this could reflect a short-term survival advantage for BRCA carriers.

A decade after diagnosis, though, that benefit seemed to have faded, and BRCA gene mutation carriers had no survival benefit, revealed the study published recently in the Journal of the National Cancer Institute.

"Our results on long-term survival differed somewhat from those in earlier studies that found a short-term survival advantage for women with BRCA mutations," said Dr. Tuya Pal, an associate member of the Moffitt cancer epidemiology program, in the news release. "However, our results for short-term survival were similar to previous studies. Our study found the survival advantage at five years for women with stage 3 cancers at 55 percent for BRCA1 and BRCA2 mutation carriers combined, versus 39 percent for non-carriers."

The researchers said more studies are needed to investigate how new treatments for BRCA mutation carriers with ovarian cancer will affect their long-term survival.

"We believe there is insufficient evidence to counsel women with ovarian cancer and a BRCA mutation that they should expect their long-term survival to be better than that of non-carriers, or that tailored treatments reflect the differences in survival," the study's authors wrote.

The researchers noted that only one of the 309 women who survived more than 12 years after being diagnosed died within the study time frame. They suggested that a 12-year survival "seems a reasonable surrogate for cure."

An inherited BRCA gene mutation is carried by 13 percent of women with ovarian cancer, according to the release. These women have a lifetime risk of up to 44 percent for developing the disease. In contrast, the risk of ovarian cancer for the general population is just 2 percent.

More information

The U.S. National Cancer Institute provides facts on BRCA1 and BRCA2 gene mutation.

-- Mary Elizabeth Dallas

SOURCE: Moffitt Cancer Center, news release, February 14, 2013.


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers Find Gene Mutations That May Be a Key to Autism
2. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
3. Cancer may require simpler genetic mutations than previously thought
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Study sheds new light on role of genetic mutations in colon cancer development
6. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
7. Study finds new gene mutations that lead to enlarged brain size, cancer, autism, epilepsy
8. Evolutionary information improves discovery of mutations associated with diseases
9. Hundreds of random mutations in leukemia linked to aging, not cancer
10. Genetic mutations that cause common childhood brain tumors identified
11. Genetic analyses reveal novel mutations as causes of startle disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... 29, 2017 , ... In the United States alone, up to 36% of ... types of metastatic brain tumors(3). Though most meningiomas are benign, metastatic brain tumors are ... more effective treatment options, the San Diego Gamma Knife Center offers a ...
(Date:3/29/2017)... Georgia (PRWEB) , ... March 29, 2017 , ... Full ... Therilus, founder of Pet Protect Law that assists dog owners in creating ... assist new owners in taking the natural next step to protect their new companion. ...
(Date:3/29/2017)... ... March 30, 2017 , ... CHARM CITY RUN WELCOMES MERCY ... announced that Mercy Medical Center will serve as the official title sponsor of the ... Sunday, June 25, 2017, thousands of women will walk or run the course around ...
(Date:3/29/2017)... ... March 30, 2017 , ... Sublime Naturals and its founder, ... or "Wonder Spice", it has been used for thousands of years. , "The West ... Heshelow, author of " Turmeric: How to Use it For Your Wellness. Overcome Inflammation, ...
(Date:3/29/2017)... ... 29, 2017 , ... Wells Pharmacy Network, a proud A4M ... upcoming World Congress, in Hollywood Florida April 6-8, 2017. , Ben David, CEO ... leader in the training of physicians, scientists, and members of the public on ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017  Novartis announced today that the US ... company,s Biologics License Application (BLA) filing and granted ... antigen receptor T cell (CAR-T) therapy, in relapsed ... with B-cell acute lymphoblastic leukemia (ALL). This is ... CAR-T. The priority review designation is expected to ...
(Date:3/29/2017)... , March 29, 2017  The Global Health ... public-private partnership formed to battle infectious diseases around ... US$23 million* that could help deliver a range ... debilitating conditions. This latest round ... 3 clinical trial testing a pediatric formulation of ...
(Date:3/29/2017)... FREMONT, Calif. , March 29, 2017 /PRNewswire/ ... vision for patients as the highest standard in ... Today, Krypton Vision introduces its objective Wavefront-driven refraction ... conventional, subjective approach. This enables an unprecedented level ... optics - exceptional vision relegated to Topgun Navy ...
Breaking Medicine Technology: