Navigation Links
Gene Mutation's Benefit for Ovarian Cancer Patients May Not Last: Study
Date:2/19/2013

TUESDAY, Feb. 19 (HealthDay News) -- Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study.

"Of those women diagnosed with invasive ovarian cancer in the United States and Canada, approximately 35 percent are expected to be long-term survivors and ultimately cured," Thomas Sellers, director of the Moffitt Cancer Center in Tampa, Fla., said in a center news release. "We sought to estimate the 10-year survival for women with ovarian cancer -- with and without the mutations -- to determine whether or not the observed short-term survival benefit for those with the mutations was associated with a better prospect for cure."

In conducting the study, the researchers examined the long-term survival of more than 1,600 women with a BRCA1 or BRCA2 gene mutation diagnosed with invasive ovarian cancer. The women were followed for up to 15 years.

In the three years after a diagnosis of invasive ovarian cancer, the researchers found a BRCA gene mutation was linked to a better prognosis. For women without a BRCA mutation, the most deaths occurred about two years after they were diagnosed. For mutation carriers, however, the most deaths occurred about 3.5 years after diagnosis. The researchers suggested this could reflect a short-term survival advantage for BRCA carriers.

A decade after diagnosis, though, that benefit seemed to have faded, and BRCA gene mutation carriers had no survival benefit, revealed the study published recently in the Journal of the National Cancer Institute.

"Our results on long-term survival differed somewhat from those in earlier studies that found a short-term survival advantage for women with BRCA mutations," said Dr. Tuya Pal, an associate member of the Moffitt cancer epidemiology program, in the news release. "However, our results for short-term survival were similar to previous studies. Our study found the survival advantage at five years for women with stage 3 cancers at 55 percent for BRCA1 and BRCA2 mutation carriers combined, versus 39 percent for non-carriers."

The researchers said more studies are needed to investigate how new treatments for BRCA mutation carriers with ovarian cancer will affect their long-term survival.

"We believe there is insufficient evidence to counsel women with ovarian cancer and a BRCA mutation that they should expect their long-term survival to be better than that of non-carriers, or that tailored treatments reflect the differences in survival," the study's authors wrote.

The researchers noted that only one of the 309 women who survived more than 12 years after being diagnosed died within the study time frame. They suggested that a 12-year survival "seems a reasonable surrogate for cure."

An inherited BRCA gene mutation is carried by 13 percent of women with ovarian cancer, according to the release. These women have a lifetime risk of up to 44 percent for developing the disease. In contrast, the risk of ovarian cancer for the general population is just 2 percent.

More information

The U.S. National Cancer Institute provides facts on BRCA1 and BRCA2 gene mutation.

-- Mary Elizabeth Dallas

SOURCE: Moffitt Cancer Center, news release, February 14, 2013.


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers Find Gene Mutations That May Be a Key to Autism
2. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
3. Cancer may require simpler genetic mutations than previously thought
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Study sheds new light on role of genetic mutations in colon cancer development
6. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
7. Study finds new gene mutations that lead to enlarged brain size, cancer, autism, epilepsy
8. Evolutionary information improves discovery of mutations associated with diseases
9. Hundreds of random mutations in leukemia linked to aging, not cancer
10. Genetic mutations that cause common childhood brain tumors identified
11. Genetic analyses reveal novel mutations as causes of startle disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... , ... December 07, 2016 , ... A. Kevin Spann ... and families throughout the Five Boroughs, is launching a charity drive to raise funds ... continue the traditions and spirit of marines and Navy FMF Corpsmen. Working closely with ...
(Date:12/7/2016)... ... 2016 , ... The Honolulu cosmetic and medical dermatology practice ... October 17, 2016, features comprehensive information regarding a wide range of dermatologic conditions, ... can discover the latest clinical dermatology treatments for medical skin concerns as well ...
(Date:12/7/2016)... ... December 07, 2016 , ... Texas Premier ... operations" carried out by unethical locksmith companies and is urging Search Engines to ... According to Texas Premier Locksmith, these fraudulent locksmith services take advantage of consumers ...
(Date:12/7/2016)... ... ... "ProBrand Flip allows FCPX editors to create unique logo reveals which can ... Film Studios. , ProBrand Flip includes 30 flip book reveal animations. Easily reveal any ... variety of flip book animations. In Addition, users can modify each preset to fit ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... Infertility and Wellness (IFW) Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin ... has a team of three acupuncturists to help patients realize their family building ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7, 2016 Diplomat Pharmacy, Inc. (NYSE: DPLO) ... subsidiaries—American Homecare Federation, At-Home IV Infusion Professional, BioRx, MedPro Rx, and ... infusion services, visit diplomat.is/specialty-infusion .  ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, ... "As we continue to build on ...
(Date:12/7/2016)... ZIONA SCIENCE PARK , Israel ... company Kadimastem (TASE: KDST) announced today the signing of a memorandum ... between the companies. The synergy between the companies will assist in ... as a worldwide leader in innovative treatment for severe diseases in ... ...
(Date:12/7/2016)... -- Based on its recent analysis of the ... recognizes Nemaura Pharma Limited with the 2016 ... Technology Leadership. Nemaura Pharma,s transdermal drug delivery ... delivery technologies, especially in delivering biologics. Its ... Memspatch and Micropatch respectively, facilitate minimally painful ...
Breaking Medicine Technology: