Navigation Links
Gene Mutation's Benefit for Ovarian Cancer Patients May Not Last: Study
Date:2/19/2013

TUESDAY, Feb. 19 (HealthDay News) -- Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study.

"Of those women diagnosed with invasive ovarian cancer in the United States and Canada, approximately 35 percent are expected to be long-term survivors and ultimately cured," Thomas Sellers, director of the Moffitt Cancer Center in Tampa, Fla., said in a center news release. "We sought to estimate the 10-year survival for women with ovarian cancer -- with and without the mutations -- to determine whether or not the observed short-term survival benefit for those with the mutations was associated with a better prospect for cure."

In conducting the study, the researchers examined the long-term survival of more than 1,600 women with a BRCA1 or BRCA2 gene mutation diagnosed with invasive ovarian cancer. The women were followed for up to 15 years.

In the three years after a diagnosis of invasive ovarian cancer, the researchers found a BRCA gene mutation was linked to a better prognosis. For women without a BRCA mutation, the most deaths occurred about two years after they were diagnosed. For mutation carriers, however, the most deaths occurred about 3.5 years after diagnosis. The researchers suggested this could reflect a short-term survival advantage for BRCA carriers.

A decade after diagnosis, though, that benefit seemed to have faded, and BRCA gene mutation carriers had no survival benefit, revealed the study published recently in the Journal of the National Cancer Institute.

"Our results on long-term survival differed somewhat from those in earlier studies that found a short-term survival advantage for women with BRCA mutations," said Dr. Tuya Pal, an associate member of the Moffitt cancer epidemiology program, in the news release. "However, our results for short-term survival were similar to previous studies. Our study found the survival advantage at five years for women with stage 3 cancers at 55 percent for BRCA1 and BRCA2 mutation carriers combined, versus 39 percent for non-carriers."

The researchers said more studies are needed to investigate how new treatments for BRCA mutation carriers with ovarian cancer will affect their long-term survival.

"We believe there is insufficient evidence to counsel women with ovarian cancer and a BRCA mutation that they should expect their long-term survival to be better than that of non-carriers, or that tailored treatments reflect the differences in survival," the study's authors wrote.

The researchers noted that only one of the 309 women who survived more than 12 years after being diagnosed died within the study time frame. They suggested that a 12-year survival "seems a reasonable surrogate for cure."

An inherited BRCA gene mutation is carried by 13 percent of women with ovarian cancer, according to the release. These women have a lifetime risk of up to 44 percent for developing the disease. In contrast, the risk of ovarian cancer for the general population is just 2 percent.

More information

The U.S. National Cancer Institute provides facts on BRCA1 and BRCA2 gene mutation.

-- Mary Elizabeth Dallas

SOURCE: Moffitt Cancer Center, news release, February 14, 2013.


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers Find Gene Mutations That May Be a Key to Autism
2. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
3. Cancer may require simpler genetic mutations than previously thought
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Study sheds new light on role of genetic mutations in colon cancer development
6. Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
7. Study finds new gene mutations that lead to enlarged brain size, cancer, autism, epilepsy
8. Evolutionary information improves discovery of mutations associated with diseases
9. Hundreds of random mutations in leukemia linked to aging, not cancer
10. Genetic mutations that cause common childhood brain tumors identified
11. Genetic analyses reveal novel mutations as causes of startle disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
Breaking Medicine Technology: