Navigation Links
Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
Date:3/19/2013

TUESDAY, March 19 (HealthDay News) -- Children who inherit certain variations in four particular genes have an increased risk of developing childhood leukemia, a new study says.

The researchers also found that Hispanic children are more likely than white or black children to inherit high-risk versions of two of the genes that can lead to acute lymphoblastic leukemia (ALL).

Rates of ALL are higher in Hispanic children than in white or black children, and these findings point to at least one reason for that difference, according to the St. Jude Children's Research Hospital-led study.

Children inherit two copies of each gene, one from each parent. That means that children could inherit up to eight high-risk versions of the four genes linked to an increased risk of ALL, the researchers said.

Children with more than five copies of the risk genes were nine times more likely to develop ALL than those with no more than one copy, according to the study published online March 19 in the Journal of the National Cancer Institute.

The study included nearly 2,500 children with ALL and nearly 11,000 without the disease.

"ALL is a complex disease that likely involves many genes. The discoveries we are reporting in this paper are an important step forward in terms of understanding why children develop ALL in the first place, particularly for those with African or Hispanic ethnicity. However, this is probably still just a small part of the complete picture," study senior author Jun Yang, an assistant member of the St. Jude Department of Pharmaceutical Sciences in Memphis, Tenn., said in a hospital news release.

This year, about 3,000 children in the United States will be diagnosed with ALL, which is the most common childhood cancer. It is also among the most curable.

More information

The Nemours Foundation has more about acute lymphoblastic leukemia.

-- Robert Preidt

SOURCE: St. Jude Children's Research Hospital, news release, March 19, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. University of Minnesota researchers discover enzyme behind breast cancer mutations
2. Some cancer mutations slow tumor growth
3. Researchers discover mutations linked to relapse of childhood leukemia
4. Researchers discover new mutations driving malignant melanoma
5. New test predicted presence of harmful BRCA mutations
6. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
7. Cleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome
8. DNA packaging discovery reveals principles by which CRC mutations may cause cancer
9. Genome-wide scan maps mutations in deadly lung cancers; reveals embryonic gene link
10. Genetic analyses reveal novel mutations as causes of startle disease
11. Genetic mutations that cause common childhood brain tumors identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... on the world stage this week. A group of researchers and leaders from ... the Progress of Regenerative Medicine and Its Cultural Impact ” and receive the ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... accessories, is proud to partner with AquaShieldUSA, the country's oldest waterproof cast ... clinic and medical supply stores, the largest selection of daily, night, weatherproof and ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... the open availability of a new CDISC standard, Clinical Trial Registry (CTR) ... trials. This innovative standard will make it possible to build applications that ...
(Date:4/28/2016)... ... April 28, 2016 , ... Trinity ... Tobacco-Free Kids, a leading force in the fight to reduce tobacco use and ... policies that can help reduce tobacco use. The initiative brings together two organizations ...
(Date:4/28/2016)... ... 28, 2016 , ... In 2011, TIME magazine named Herr the “Leader of ... technology that marries human physiology with electromechanics. He continues that work as Director of ... of BionX , a leader in the field of prosthetic devices. , After ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)...  The blood testing market in China ... Information and The Freedonia Group in a recent report.  ... The healthcare research firm said that China ... stations and in improving testing at the provincial level.  ... Blood Testing Market in China , which ...
(Date:4/28/2016)... 2016 , Net Sales of $1.90 billion ... the prior year period, and an increase of 1.2% on ... EPS for the first quarter were $0.52 reported, a decrease ... an increase of 29.9% over the prior year period ... guidance for 2016 Zimmer Biomet Holdings, Inc. (NYSE ...
(Date:4/28/2016)... Oramed Pharmaceuticals Inc. (NASDAQ: ... on the development of oral drug delivery systems, announced today ... conference, presented by Joseph Gunnar & Co. LLC, ... York . Nadav Kidron , CEO of Oramed, ... Presentation Details:   PIONEERS 2016, presented by ...
Breaking Medicine Technology: