Navigation Links
Gene Mutation in Dalmatians Sheds Light on Kidney Stones in Humans
Date:11/7/2008

Finding explained high levels of uric acid in dog breed

FRIDAY, Nov. 7 (HealthDay News) -- A gene mutation that causes the high levels of uric acid that lead to bladder stones in Dalmatians has been identified by U.S. researchers, who said the finding may provide clues about kidney stones in humans.

Among mammals, only humans, great apes and Dalmatians produce elevated levels of uric acid in their urine and blood. Other dog breeds don't usually produce uric acid.

The team in the School of Veterinary Medicine at the University of California, Davis, analyzed DNA and urine samples from hundreds of dogs and found that mutations in the SLC2A9 gene caused elevated uric acid in Dalmatians. The study was published in the Nov. 7 issue of PLoS Genetics.

In Dalmatians, high uric acid levels result in the formation of bladder stones that often have to be removed surgically. In humans, high levels of uric acid can cause kidney stones, hypertension and gout -- a painful inflammation of the joints.

Humans also carry the SLC2A9 gene, but the exact mechanism that causes high uric acid levels in humans and great apes hasn't been pinpointed. This finding in Dalmatians may help in that research.

"This defect [in Dalmatians] has been reported for nearly a century, and was probably unintentionally introduced as breeders worked to select more distinctive spotting patterns," study author Danika Bannasch, a veterinary geneticist, said in a PLoS Genetics news release.

"This trait can now be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s," Bannasch said. "The result is a healthy dog that looks like a Dalmatian, maintains the Dalmatian breed characteristics and is genetically almost identical."

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about gout.



-- Robert Preidt



SOURCE: PLoS Genetics, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutation May Cause Some Cases of Seasonal Affective Disorder
2. Risk of breast cancer mutations underestimated for Asian women, Stanford study shows
3. Genetic Mutations Linked to Deadly Cancers
4. Inherited form of hearing loss stems from gene mutation
5. Gene Mutation Puts Some Kids at Risk for Tobacco Addiction
6. Common Mechanisms May Contribute to Autisms Mutations
7. Gene Mutation Tied to Inherited Atrial Fibrillation
8. Migraine mutations reveal clues to biological basis of disorder
9. Caris Diagnostics Providing KRAS Mutational Analysis for Colon Cancer Patients
10. New research on mutation in yeast can enhance understanding of human diseases
11. Gene mutation improves leukemia drugs effect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... Rosa, California (PRWEB) , ... May 23, 2017 ... ... health management (PHM) technology and a 2017 Best in KLAS category winner, has ... advantageous market position to extend and enhance its technology platform and product offerings,” ...
(Date:5/23/2017)... Rosa, CA (PRWEB) , ... May 23, 2017 , ... ... mosquito season underway in Sonoma County. While officials call for diligence, asking homeowners to ... are looking at potential health concerns. Along with the annoying buzz of mosquitos is ...
(Date:5/23/2017)... ... ... New patients from Charleston, SC, are now welcome to receive a full ... with or without a referral. A full mouth reconstruction can transform the appearance of ... Charleston, SC. Those who suffer from gum disease, misaligned teeth or jaw pain can ...
(Date:5/23/2017)... ... May 23, 2017 , ... Therachat , a smart ... in an infographic on the current state of anxiety in support of National Mental ... was conducted in April 2017 and benchmarked general anxiety levels as well as identified ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... ... Periodontics, is now welcoming new patients with periodontal plastic surgery treatments, including ... a general dentist. Dr. Green provides these esthetic and functional procedures to help ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)... , May 12, 2017  The China and ... washing technology that consumes less water, energy and detergent, and features ... first product LaughingU, a shoebox-sized washing machine that washes and sanitizes ... ... Product, LaughingU, is compact, and does not require an external water ...
(Date:5/10/2017)... , May 10, 2017  The Corporate Whistleblower ... employees of sleep therapy clinics to call us ... therapy clinic is involved in a substantial scheme ... in hearing from an employee of a medical ... a kickback scheme to provide medical practice groups with ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its commitment ... of directors for the Pharmaceutical Research and Manufacturers ... membership. Biopharmaceutical companies will now have to meet ... to be eligible to join PhRMA. ... board is sending a clear message that being ...
Breaking Medicine Technology: