Navigation Links
Gene Mutation in Dalmatians Sheds Light on Kidney Stones in Humans
Date:11/7/2008

Finding explained high levels of uric acid in dog breed

FRIDAY, Nov. 7 (HealthDay News) -- A gene mutation that causes the high levels of uric acid that lead to bladder stones in Dalmatians has been identified by U.S. researchers, who said the finding may provide clues about kidney stones in humans.

Among mammals, only humans, great apes and Dalmatians produce elevated levels of uric acid in their urine and blood. Other dog breeds don't usually produce uric acid.

The team in the School of Veterinary Medicine at the University of California, Davis, analyzed DNA and urine samples from hundreds of dogs and found that mutations in the SLC2A9 gene caused elevated uric acid in Dalmatians. The study was published in the Nov. 7 issue of PLoS Genetics.

In Dalmatians, high uric acid levels result in the formation of bladder stones that often have to be removed surgically. In humans, high levels of uric acid can cause kidney stones, hypertension and gout -- a painful inflammation of the joints.

Humans also carry the SLC2A9 gene, but the exact mechanism that causes high uric acid levels in humans and great apes hasn't been pinpointed. This finding in Dalmatians may help in that research.

"This defect [in Dalmatians] has been reported for nearly a century, and was probably unintentionally introduced as breeders worked to select more distinctive spotting patterns," study author Danika Bannasch, a veterinary geneticist, said in a PLoS Genetics news release.

"This trait can now be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s," Bannasch said. "The result is a healthy dog that looks like a Dalmatian, maintains the Dalmatian breed characteristics and is genetically almost identical."

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about gout.



-- Robert Preidt



SOURCE: PLoS Genetics, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutation May Cause Some Cases of Seasonal Affective Disorder
2. Risk of breast cancer mutations underestimated for Asian women, Stanford study shows
3. Genetic Mutations Linked to Deadly Cancers
4. Inherited form of hearing loss stems from gene mutation
5. Gene Mutation Puts Some Kids at Risk for Tobacco Addiction
6. Common Mechanisms May Contribute to Autisms Mutations
7. Gene Mutation Tied to Inherited Atrial Fibrillation
8. Migraine mutations reveal clues to biological basis of disorder
9. Caris Diagnostics Providing KRAS Mutational Analysis for Colon Cancer Patients
10. New research on mutation in yeast can enhance understanding of human diseases
11. Gene mutation improves leukemia drugs effect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... The iaedp Foundation, recognized ... treatment providers who treat the full spectrum of eating disorder problems, proudly announces ... Council consists of the leading eating disorder treatments centers located throughout the U.S. ...
(Date:1/23/2017)... ... ... Sharon Kleyne, America’s leading water researcher, advocate and feared enemy of dry ... new water infrastructure a number one priority. “As we usher in a new national ... become a top priority of our new political change agents.” Kleyne pointed out that ...
(Date:1/23/2017)... ... January 23, 2017 , ... METTLER TOLEDO has ... Chemistry by Applying Simple PAT Tools . , Crystallization is a ... the desired product. Chemists now spend more time developing better intermediate and ...
(Date:1/23/2017)... , ... January 23, 2017 , ... "ProRandom is a set of camera tools that ... dynamic looks in Final Cut Pro X," said Christina Austin - CEO of Pixel Film ... two layers of text with video footage. ProRandom works by using a virtual camera ...
(Date:1/23/2017)... ... 23, 2017 , ... Gynecology Associates of Gwinnett (GAoG) has ... for women of all ages. The staff of Gynecology Associates of Gwinnett ... from routine health screenings to diagnosing and treating female concerns including menopause, urinary ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Jan. 23, 2017  Delcath Systems, Inc. (NASDAQ: ... the treatment of primary and metastatic liver cancers, today ... CRNP, President and Chief Executive Officer of Delcath will ... Capital Markets, Thirteenth Annual Investor Conference at the Boca ... Florida , on Tuesday, January 31, 2017 at ...
(Date:1/23/2017)... , January 23, 2017 ... (r enal) y el riesgo ... de a pabetalone    Resverlogix Corp. ... resultados preliminares de un ensayo en fase 1 con ... de riñón (renal) severa. Los datos demostraron unos resultados ...
(Date:1/23/2017)... The global  anxiety disorders and depression treatment market  is expected to reach ... worldwide is anticipated to drive the market growth in the coming years. Increasing ... in the recent years. Continue Reading ... ... ...
Breaking Medicine Technology: