Navigation Links
Gene Mutation in Dalmatians Sheds Light on Kidney Stones in Humans
Date:11/7/2008

Finding explained high levels of uric acid in dog breed

FRIDAY, Nov. 7 (HealthDay News) -- A gene mutation that causes the high levels of uric acid that lead to bladder stones in Dalmatians has been identified by U.S. researchers, who said the finding may provide clues about kidney stones in humans.

Among mammals, only humans, great apes and Dalmatians produce elevated levels of uric acid in their urine and blood. Other dog breeds don't usually produce uric acid.

The team in the School of Veterinary Medicine at the University of California, Davis, analyzed DNA and urine samples from hundreds of dogs and found that mutations in the SLC2A9 gene caused elevated uric acid in Dalmatians. The study was published in the Nov. 7 issue of PLoS Genetics.

In Dalmatians, high uric acid levels result in the formation of bladder stones that often have to be removed surgically. In humans, high levels of uric acid can cause kidney stones, hypertension and gout -- a painful inflammation of the joints.

Humans also carry the SLC2A9 gene, but the exact mechanism that causes high uric acid levels in humans and great apes hasn't been pinpointed. This finding in Dalmatians may help in that research.

"This defect [in Dalmatians] has been reported for nearly a century, and was probably unintentionally introduced as breeders worked to select more distinctive spotting patterns," study author Danika Bannasch, a veterinary geneticist, said in a PLoS Genetics news release.

"This trait can now be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s," Bannasch said. "The result is a healthy dog that looks like a Dalmatian, maintains the Dalmatian breed characteristics and is genetically almost identical."

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about gout.



-- Robert Preidt



SOURCE: PLoS Genetics, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutation May Cause Some Cases of Seasonal Affective Disorder
2. Risk of breast cancer mutations underestimated for Asian women, Stanford study shows
3. Genetic Mutations Linked to Deadly Cancers
4. Inherited form of hearing loss stems from gene mutation
5. Gene Mutation Puts Some Kids at Risk for Tobacco Addiction
6. Common Mechanisms May Contribute to Autisms Mutations
7. Gene Mutation Tied to Inherited Atrial Fibrillation
8. Migraine mutations reveal clues to biological basis of disorder
9. Caris Diagnostics Providing KRAS Mutational Analysis for Colon Cancer Patients
10. New research on mutation in yeast can enhance understanding of human diseases
11. Gene mutation improves leukemia drugs effect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “America On ... Christian identity. “America On The Brink” is the creation of published author, William ... several great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader ... a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were ... 11, 2017. , The annual award competition recognizes editorial and design excellence across a ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 ... performance ratings for global supply chains, has published the first annual edition ... CSR performance of more than 20,400 companies evaluated by EcoVadis, based on ... 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
Breaking Medicine Technology: