Navigation Links
Gene Mutation in Dalmatians Sheds Light on Kidney Stones in Humans
Date:11/7/2008

Finding explained high levels of uric acid in dog breed

FRIDAY, Nov. 7 (HealthDay News) -- A gene mutation that causes the high levels of uric acid that lead to bladder stones in Dalmatians has been identified by U.S. researchers, who said the finding may provide clues about kidney stones in humans.

Among mammals, only humans, great apes and Dalmatians produce elevated levels of uric acid in their urine and blood. Other dog breeds don't usually produce uric acid.

The team in the School of Veterinary Medicine at the University of California, Davis, analyzed DNA and urine samples from hundreds of dogs and found that mutations in the SLC2A9 gene caused elevated uric acid in Dalmatians. The study was published in the Nov. 7 issue of PLoS Genetics.

In Dalmatians, high uric acid levels result in the formation of bladder stones that often have to be removed surgically. In humans, high levels of uric acid can cause kidney stones, hypertension and gout -- a painful inflammation of the joints.

Humans also carry the SLC2A9 gene, but the exact mechanism that causes high uric acid levels in humans and great apes hasn't been pinpointed. This finding in Dalmatians may help in that research.

"This defect [in Dalmatians] has been reported for nearly a century, and was probably unintentionally introduced as breeders worked to select more distinctive spotting patterns," study author Danika Bannasch, a veterinary geneticist, said in a PLoS Genetics news release.

"This trait can now be removed from the breed by crossing Dalmatians with the normal offspring of the original Dalmatian-pointer breeding that occurred in the early 1970s," Bannasch said. "The result is a healthy dog that looks like a Dalmatian, maintains the Dalmatian breed characteristics and is genetically almost identical."

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about gout.



-- Robert Preidt



SOURCE: PLoS Genetics, news release, Nov. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutation May Cause Some Cases of Seasonal Affective Disorder
2. Risk of breast cancer mutations underestimated for Asian women, Stanford study shows
3. Genetic Mutations Linked to Deadly Cancers
4. Inherited form of hearing loss stems from gene mutation
5. Gene Mutation Puts Some Kids at Risk for Tobacco Addiction
6. Common Mechanisms May Contribute to Autisms Mutations
7. Gene Mutation Tied to Inherited Atrial Fibrillation
8. Migraine mutations reveal clues to biological basis of disorder
9. Caris Diagnostics Providing KRAS Mutational Analysis for Colon Cancer Patients
10. New research on mutation in yeast can enhance understanding of human diseases
11. Gene mutation improves leukemia drugs effect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... The Aesthetic ... facelift . Dr. Talei has come up with a proprietary technique that he calls ... lifts tissues that have dropped. For all ages, patients can expect to look refreshed, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Georgia State ... 18 to 20. , The two-day conference is focused on advancing scientific knowledge ... improving patients’ lives and eliminating racial breast cancer-related disparities. The conference theme is ...
(Date:6/23/2017)... ... June 23, 2017 , ... MD Now Urgent ... is MD Now’s 28th facility overall and marks the urgent care center's eighth location ... mile North of The Falls shopping mall. The new clinic offers a wide array ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... Insurance offerings. With the Federal Emergency Management Agency’s (FEMA) recent update of flood ... States. In 2012, the Biggert-Waters Act was enacted to reflect the actual risk ...
(Date:6/23/2017)... , ... June 23, 2017 , ... Ulster University, Magee ... 2017 from 9 am to 3 pm to present to graduate students exciting new ... is an original curriculum project led by The Health Improvement Service of the Western ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... The Bio Supply Management Alliance (BSMA) has ... and the Biomedical Manufacturing Network to advance ... California by providing a platform for ... workforce development. The primary focus of this alliance is ... well as small and mid-sized biomedical companies. ...
(Date:6/11/2017)... 2017  Eli Lilly and Company (NYSE: LLY ... studies of galcanezumab, an investigational treatment for the prevention ... several key secondary endpoints for galcanezumab compared to placebo ... (EVOLVE-1, EVOLVE-2 and REGAIN) will be presented today at ... Boston . "The ...
(Date:6/8/2017)... June 8, 2017  Less than a month ago, ... than 200,000 companies, including hospital networks, in over 150 ... one of the largest online extortion attempts ever recorded. ... market, it is imperative that providers understand where the ... from this — and many other very real cyber ...
Breaking Medicine Technology: