Navigation Links
Gene Mutation Ups Risk of Sudden Death in People with Epilepsy

Patients who have gene variant are 10 times more likely to die without warning, study finds

WEDNESDAY, April 14 (HealthDay News) -- A mutation in a gene called Kv1.1 appears to be associated with irregular heart beat and sudden death in people with epilepsy, a new study finds.

People with epilepsy who are otherwise healthy are 10 times more likely than normal to die suddenly and unexpectedly. It's long been suspected that the abnormal ion channels in cells that cause epilepsy also increase the risk of sudden death by affecting the heart.

Ion channels are proteins involved in nerve cell communication. In humans, the potassium ion channel Kv1.1 helps regulate electrical signals in the brain. Mutation of the gene for Kv1.1 has been associated with spontaneous seizures, abnormal muscle movement, and problems with motor coordination. This new study found that mutation of the Kv1.1 gene also affects heart function.

Mice that were bred to lack the gene for Kv1.1 channels showed signs of severe epilepsy and involuntary movement, and died prematurely due to erratic heart rhythms caused by problems in communication between the brain and the heart.

Study authors speculated that in mice without Kv1.1 channels, the vagus nerve -- which helps regulate cardiac rhythms by sending brain signals to the heart -- loses control. The nerve then "sends extra impulses to the heart, telling it to slow down, and even stop beating, when it shouldn't," study first author Edward Glasscock, of Baylor College of Medicine in Houston, Texas, said in a news release.

The findings, published in the April 14 issue of The Journal of Neuroscience, could lead to better treatments for at-risk patients, the researchers said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about epilepsy.

-- Robert Preidt

SOURCE: Society for Neuroscience, news release, April 13, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutations Up Risk for Cancer in Opposite Breast
2. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
3. Parkinsons Linked to Genetic Mutation
4. Study shows that mutations in 1 gene cause many cancers
5. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
6. Genetic Mutation Linked to Prostate Cancer in Blacks
7. Single gene mutation induces endometrial cancer
8. Gene Mutations Behind Brain Reduction
9. Minnesota State High School League and Take Heart Minnesota Team Up to Save More Lives From Sudden Cardiac Arrest (SCA)
10. As girth grows, risk of sudden cardiac death shrinks
11. Serotonin May Be Key to Sudden Infant Deaths
Post Your Comments:
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from reveals that behind the ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology: