Navigation Links
Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
Date:4/14/2010

Patients who have gene variant are 10 times more likely to die without warning, study finds

WEDNESDAY, April 14 (HealthDay News) -- A mutation in a gene called Kv1.1 appears to be associated with irregular heart beat and sudden death in people with epilepsy, a new study finds.

People with epilepsy who are otherwise healthy are 10 times more likely than normal to die suddenly and unexpectedly. It's long been suspected that the abnormal ion channels in cells that cause epilepsy also increase the risk of sudden death by affecting the heart.

Ion channels are proteins involved in nerve cell communication. In humans, the potassium ion channel Kv1.1 helps regulate electrical signals in the brain. Mutation of the gene for Kv1.1 has been associated with spontaneous seizures, abnormal muscle movement, and problems with motor coordination. This new study found that mutation of the Kv1.1 gene also affects heart function.

Mice that were bred to lack the gene for Kv1.1 channels showed signs of severe epilepsy and involuntary movement, and died prematurely due to erratic heart rhythms caused by problems in communication between the brain and the heart.

Study authors speculated that in mice without Kv1.1 channels, the vagus nerve -- which helps regulate cardiac rhythms by sending brain signals to the heart -- loses control. The nerve then "sends extra impulses to the heart, telling it to slow down, and even stop beating, when it shouldn't," study first author Edward Glasscock, of Baylor College of Medicine in Houston, Texas, said in a news release.

The findings, published in the April 14 issue of The Journal of Neuroscience, could lead to better treatments for at-risk patients, the researchers said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about epilepsy.



-- Robert Preidt



SOURCE: Society for Neuroscience, news release, April 13, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutations Up Risk for Cancer in Opposite Breast
2. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
3. Parkinsons Linked to Genetic Mutation
4. Study shows that mutations in 1 gene cause many cancers
5. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
6. Genetic Mutation Linked to Prostate Cancer in Blacks
7. Single gene mutation induces endometrial cancer
8. Gene Mutations Behind Brain Reduction
9. Minnesota State High School League and Take Heart Minnesota Team Up to Save More Lives From Sudden Cardiac Arrest (SCA)
10. As girth grows, risk of sudden cardiac death shrinks
11. Serotonin May Be Key to Sudden Infant Deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... On Saturday, ... a treadmill relay – Miles by Moonlight to raise money for the American Heart ... or more. , Teams will work together to keep their treadmills moving for ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/19/2017)... Ky. , Sept. 19, 2017   ZirMed Inc ... predictive analytics, today announced that it has been ranked #1 ... Black Book™ Rankings 2017 User Survey. ZirMed was ... solution for large hospitals and medical centers over 200 beds ... Black Book,s healthcare technology user survey history. ...
Breaking Medicine Technology: