Navigation Links
Gene Mutation Ups Risk of Sudden Death in People with Epilepsy

Patients who have gene variant are 10 times more likely to die without warning, study finds

WEDNESDAY, April 14 (HealthDay News) -- A mutation in a gene called Kv1.1 appears to be associated with irregular heart beat and sudden death in people with epilepsy, a new study finds.

People with epilepsy who are otherwise healthy are 10 times more likely than normal to die suddenly and unexpectedly. It's long been suspected that the abnormal ion channels in cells that cause epilepsy also increase the risk of sudden death by affecting the heart.

Ion channels are proteins involved in nerve cell communication. In humans, the potassium ion channel Kv1.1 helps regulate electrical signals in the brain. Mutation of the gene for Kv1.1 has been associated with spontaneous seizures, abnormal muscle movement, and problems with motor coordination. This new study found that mutation of the Kv1.1 gene also affects heart function.

Mice that were bred to lack the gene for Kv1.1 channels showed signs of severe epilepsy and involuntary movement, and died prematurely due to erratic heart rhythms caused by problems in communication between the brain and the heart.

Study authors speculated that in mice without Kv1.1 channels, the vagus nerve -- which helps regulate cardiac rhythms by sending brain signals to the heart -- loses control. The nerve then "sends extra impulses to the heart, telling it to slow down, and even stop beating, when it shouldn't," study first author Edward Glasscock, of Baylor College of Medicine in Houston, Texas, said in a news release.

The findings, published in the April 14 issue of The Journal of Neuroscience, could lead to better treatments for at-risk patients, the researchers said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about epilepsy.

-- Robert Preidt

SOURCE: Society for Neuroscience, news release, April 13, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutations Up Risk for Cancer in Opposite Breast
2. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
3. Parkinsons Linked to Genetic Mutation
4. Study shows that mutations in 1 gene cause many cancers
5. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
6. Genetic Mutation Linked to Prostate Cancer in Blacks
7. Single gene mutation induces endometrial cancer
8. Gene Mutations Behind Brain Reduction
9. Minnesota State High School League and Take Heart Minnesota Team Up to Save More Lives From Sudden Cardiac Arrest (SCA)
10. As girth grows, risk of sudden cardiac death shrinks
11. Serotonin May Be Key to Sudden Infant Deaths
Post Your Comments:
(Date:10/13/2017)... ... 13, 2017 , ... The American Board of Family Medicine's (ABFM) Board of ... Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve ... Puffer’s retirement at the end of 2018. Upon assuming the role of President and ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice ... of cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU ...
(Date:10/13/2017)... ... 13, 2017 , ... Many families have long-term insurance that covers care for ... a waiver for care if the client has a cognitive impairment diagnosis. , ... care, is often waived, so the benefits from their insurance start immediately,” said Mechell ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Halo Labs announces the European launch of their new ... at MIBio 2017 in Cambridge, U.K on ... in biopharmaceutical samples with unprecedented speed and sensitivity while using far ... Membrane Imaging. ... particle analysis system ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
Breaking Medicine Technology: