Navigation Links
Gene Mutation Tied to Inherited Fatal Lung Disease
Date:12/30/2008

Those with variant had cancer as well as idiopathic pulmonary fibrosis, study finds

TUESDAY, Dec. 30 (HealthDay News) -- A mutation in a gene previously found to help protect the lungs against toxins may also be linked to lung cancer and some inherited cases of a lethal lung disease affecting older adults, a new study says.

Mutations in the SFTPA2 gene have been found in families with the inherited version of idiopathic pulmonary fibrosis, or IPF -- a disease that affects about 200,000 people in the United States. The disease usually affects people age 50 and older, causing severe scarring of the lungs that results in about 40,000 deaths annually, according to the Pulmonary Fibrosis Foundation. About one in 50 people with IPF have an inherited form of the disease, for which there is no cure beyond a lung transplant.

The findings were published in the January issue of The American Journal of Human Genetics.

The SFTPA2 gene normally produces the surfactant protein A2 in the fluid of the lungs, and it helps protect the organ from invading pathogens.

In the study, in which University of Texas Southwestern researchers looked at people with the inherited form of the disease, many of those with the mutation had lung cancer as well as IPF. The researchers suspect the mutations are tied to both.

The research team is now working on molecular studies to find out why these gene mutations increase the risk for lung cancer or IPF.

More information

The National Heart, Lung, and Blood Institute has more about idiopathic pulmonary fibrosis.



-- Kevin McKeever



SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, Dec. 19, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene Mutations May Cause Rare Neonatal Diabetes
2. Gene Mutation Linked to Parkinsons Disease
3. Research shows how genetic mutation causes epilepsy in infants
4. Gene Mutation Key to Infertility in Male Mice
5. Overlooked Mutation Can Spur HIV Drug Resistance
6. OHSU Cancer Institute researcher discovers what fuels certain cancer mutation
7. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
8. BRCA1 Mutation Prevalent Among Hispanic, Younger Black Women
9. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
10. BRCA Mutations Dont Raise Breast Cancer Risk Equally
11. Genetic Mutations Boost Prostate Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Tied to Inherited Fatal Lung Disease
(Date:10/13/2017)... ... October 13, 2017 , ... ... that offers insurance and financial preparation services, is providing an update on a ... organization. , Rock City Rescue is a locally recognized nonprofit that provides shelter ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of Eating ... excellence for the field of eating disorders, announces the opening of early registration ... Orlando, Florida at the Omni Resort at ChampionsGate. , The annual ...
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
Breaking Medicine Technology: