Navigation Links
Gene Mutation Suggests New Treatment Target for Specific Lymphoma
Date:12/22/2010

WEDNESDAY, Dec. 22 (HealthDay News) -- Researchers have identified a gene mutation that may offer a target for new treatments for a type of lymphoma.

The team found that a mutation of the MYD88 gene is one of the most frequent genetic abnormalities in patients with this cancer, known as large B cell lymphoma.

The MYD88 gene encodes a protein that is crucial for normal immune response to invading microorganisms. The mutation identified in this study can cause uncontrolled cellular signaling, resulting in the survival of malignant cells.

A subgroup of the large B cell lymphoma that has a dismally low cure rate -- known as the activated B cell-like (ABC) subtype -- appears particularly susceptible to the gene.

Lymphoma is a cancer of the blood that starts in white blood cells. Diffuse large B cell lymphoma, in turn, is a type of non-Hodgkin lymphoma, in which white blood cells known as lymphocytes multiply out of control. There are three subtypes of diffuse large cell lymphoma: Patients with the ABC form have the lowest rate of three-year survival, with only 40 percent reaching that milestone.

The researchers, led by scientists at the U.S. National Cancer Institute (NCI), found that the mutant form of MYD88 allowed the ABC lymphoma cells to survive but the non-mutated version did not.

One more piece of the puzzle was unraveled through another cell-signalling protein called IRAK4. The researchers found it functioned as an enzyme to modify a substance called IRAK1, which was required for the mutant MYD88 protein to promote lymphoma cell survival.

"We believe the results of this study may provide a method to identify patients with the [ABC subtype] whose tumors may depend upon MYD88 signaling," study author Louis M. Staudt, of NCI's Center for Cancer Research, said in an NCI news release.

These patients, he said, may thus benefit from therapies targeting "regulatory pathways that sustain the survival of these lymphoma cells."

The study appears online Dec. 22 in the journal Nature.

More information

The American Cancer Society has more about non-Hodgkin lymphoma.

-- Robert Preidt

SOURCE: U.S. National Cancer Institute, news release, Dec. 22, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Single gene mutation induces endometrial cancer
2. Genetic Mutation Linked to Prostate Cancer in Blacks
3. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
4. Study shows that mutations in 1 gene cause many cancers
5. Parkinsons Linked to Genetic Mutation
6. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
7. Gene Mutations Up Risk for Cancer in Opposite Breast
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
10. New research indicates that DNA sequence itself influences mutation rate
11. Single Lung Tumor Contains 50,000 Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Suggests New Treatment Target for Specific Lymphoma
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... awareness about the dangers associated with chronic pain and the benefits of holistic treatments, ... for individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
Breaking Medicine Technology: