Navigation Links
Gene Mutation Puts Some Kids at Risk for Tobacco Addiction
Date:7/17/2008

Having 2 copies of variant, puffing before age 17 boosted odds for being heavy smoker

THURSDAY, July 17 (HealthDay News) -- People with certain common genetic variations that affect their nicotine receptors seem to be at higher risk for becoming life-long nicotine addicts if they begin smoking before they turn 17, a new study says.

"We know that people who begin smoking at a young age are more likely to face severe nicotine dependence later in life," Robert Weiss, study lead author and professor of human genetics at the University of Utah, said in a university news release. "This finding suggests that genetic influences expressed during adolescence contribute to the risk of lifetime addiction severity produced from the early onset of tobacco use."

The findings should one day help with public health interventions to counter smoking, the researchers said.

"In recent years, we've seen an explosion in the understanding of how small genetic variations can impact all aspects of health, including addiction," said Dr. Nora Volkow, director of the U.S. National Institute on Drug Abuse (NIDA), also in the news release. "As we learn more about how both genes and environment play a role in smoking, we will be able to better tailor both prevention and cessation programs to individuals."

The study was published in the July 11 issue of PLoS Genetics and, in addition to researchers at the University of Utah, involved investigators at the University of Wisconsin-Madison.

The gene variations in question are called single nucleotide polymorphisms (SNPs). SNPs that are linked and passed on together are called a haplotype.

In this study, which involved 2,827 long-term smokers of European-American descent, one haplotype for the nicotine receptor increased the risk of individuals becoming heavy smokers later in life.

Participants who took their first drag on a cigarette before the age of 17 and who also had two copies of the high-risk haplotype had a 1.6- to almost five-fold increased risk of being heavy smokers as adults.

Those who had the haplotype but did not begin smoking until 17 or later were not at an increased risk of life-long addiction.

People with a second haplotype had a reduced risk of becoming heavy smokers as adults even if they acquired the habit as youngsters, the study said.

More information

To learn more, visit the Campaign for Tobacco-Free Kids.



-- HeathDay Staff



SOURCE: University of Utah, news release, July 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutations May Cause Rare Neonatal Diabetes
2. Gene Mutation Linked to Parkinsons Disease
3. Research shows how genetic mutation causes epilepsy in infants
4. Gene Mutation Key to Infertility in Male Mice
5. Overlooked Mutation Can Spur HIV Drug Resistance
6. OHSU Cancer Institute researcher discovers what fuels certain cancer mutation
7. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
8. BRCA1 Mutation Prevalent Among Hispanic, Younger Black Women
9. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
10. BRCA Mutations Dont Raise Breast Cancer Risk Equally
11. Genetic Mutations Boost Prostate Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... September 22, 2017 , ... Happy Living’s mission - to improve ... carries it into the entertaining and delicious worlds of theatre and wines. , ... Living) convinced him to turn his play into a book. The Greener The Grass ...
(Date:9/22/2017)... ... September 22, 2017 , ... "Success ... the world of Alzheimer’s. Alzheimer’s is a disease estimated to affect the lives ... information published by the Alzheimer’s Association, a leading voice in the fight for ...
(Date:9/22/2017)... ... September 22, 2017 , ... Egg freezing ... Although frozen embryos have a slight statistical advantage for live births, frozen eggs ... wonderful opportunity for women undergoing medical treatment or who are concerned about the ...
(Date:9/21/2017)... ... September 21, 2017 , ... SABRE is raising awareness about personal safety ... the end of November. , The Chicago, Illinois, based self-defense brand has been waiting ... about the ease of taking their personal safety into their own hands. , The ...
(Date:9/21/2017)... San Diego, Ca (PRWEB) , ... September 21, 2017 , ... ... and affordable services to its customers, and give back to the community. For over ... on of the most successful companies serving plumbing in San Diego. They ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ... focused on the development of oral drug delivery systems, ... with the U.S. Food and Drug Administration (FDA) regarding ... At the meeting, the FDA ... of ORMD-0801, would be a Biologics License Application (BLA).  ...
(Date:9/1/2017)... -- Bayer will present the latest research from across its growing ... 2017 Congress, September 8-12 in Madrid, Spain ... data on Bayer,s marketed portfolio and late-stage compounds as well ... "We value the opportunity to meet ... ESMO," said Carsten Brunn , Head of Pharmaceuticals, Americas ...
(Date:8/29/2017)... In a move that promises to exponentially ... veterinary practices of all sizes, Cubex LLC and The ... TITAN,s expertise in physical security, drug diversion investigations, staff ... "Every veterinary ... is at risk today," said TITAN founder and CEO, ...
Breaking Medicine Technology: