Navigation Links
Gene Mutation Puts Some Kids at Risk for Tobacco Addiction
Date:7/17/2008

Having 2 copies of variant, puffing before age 17 boosted odds for being heavy smoker

THURSDAY, July 17 (HealthDay News) -- People with certain common genetic variations that affect their nicotine receptors seem to be at higher risk for becoming life-long nicotine addicts if they begin smoking before they turn 17, a new study says.

"We know that people who begin smoking at a young age are more likely to face severe nicotine dependence later in life," Robert Weiss, study lead author and professor of human genetics at the University of Utah, said in a university news release. "This finding suggests that genetic influences expressed during adolescence contribute to the risk of lifetime addiction severity produced from the early onset of tobacco use."

The findings should one day help with public health interventions to counter smoking, the researchers said.

"In recent years, we've seen an explosion in the understanding of how small genetic variations can impact all aspects of health, including addiction," said Dr. Nora Volkow, director of the U.S. National Institute on Drug Abuse (NIDA), also in the news release. "As we learn more about how both genes and environment play a role in smoking, we will be able to better tailor both prevention and cessation programs to individuals."

The study was published in the July 11 issue of PLoS Genetics and, in addition to researchers at the University of Utah, involved investigators at the University of Wisconsin-Madison.

The gene variations in question are called single nucleotide polymorphisms (SNPs). SNPs that are linked and passed on together are called a haplotype.

In this study, which involved 2,827 long-term smokers of European-American descent, one haplotype for the nicotine receptor increased the risk of individuals becoming heavy smokers later in life.

Participants who took their first drag on a cigarette before the age of 17 and who also had two copies of the high-risk haplotype had a 1.6- to almost five-fold increased risk of being heavy smokers as adults.

Those who had the haplotype but did not begin smoking until 17 or later were not at an increased risk of life-long addiction.

People with a second haplotype had a reduced risk of becoming heavy smokers as adults even if they acquired the habit as youngsters, the study said.

More information

To learn more, visit the Campaign for Tobacco-Free Kids.



-- HeathDay Staff



SOURCE: University of Utah, news release, July 10, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Mutations May Cause Rare Neonatal Diabetes
2. Gene Mutation Linked to Parkinsons Disease
3. Research shows how genetic mutation causes epilepsy in infants
4. Gene Mutation Key to Infertility in Male Mice
5. Overlooked Mutation Can Spur HIV Drug Resistance
6. OHSU Cancer Institute researcher discovers what fuels certain cancer mutation
7. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
8. BRCA1 Mutation Prevalent Among Hispanic, Younger Black Women
9. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
10. BRCA Mutations Dont Raise Breast Cancer Risk Equally
11. Genetic Mutations Boost Prostate Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... ProVest Insurance Group, a family managed ... Raleigh regions, is organizing an extended charity drive to benefit the family of ... , After struggling since birth with several health challenges, T.J. was later diagnosed ...
(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... N.Y (PRWEB) , ... October 13, 2017 , ... Lori ... became a member of ElderCounsel, a national organization of elder law and special needs ... changing laws and rules. It also provides a forum to network with elder law ...
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses pulsed ...   ... Jim Bertolina, ... Tom Tefft ... medical device executive Josh Stopek , PhD, who has led R&D and business development ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
(Date:9/12/2017)... 2017  Consumer reviews on the independent review site Consumer ... one company for hearing aids, ranking it higher than Miracle ... ... Consumers For Hearing Aids ... an online store that provides high performance, state-of-the-art, German-engineered hearing aids ...
Breaking Medicine Technology: