Navigation Links
Gene Mutation Offers Clues to Tamoxifen-Blood Clot Link
Date:6/17/2010

Women who developed embolism during cancer treatment more likely to have variant, study shows

THURSDAY, June 17 (HealthDay News) -- Researchers have identified a gene mutation that increases the risk of blood clots in women taking the anti-cancer drug tamoxifen after surgery for early-stage breast cancer.

Tamoxifen is widely used for patients with hormone receptor-positive breast cancer, but previous studies have shown that it increases the risk of blood clots, according to background information in a news release about the new study.

The study included 412 women, median age 64, who received tamoxifen as "adjuvant" treatment for stage I, II or IIIA breast cancer. In cancer therapy, an adjuvant treatment is one used after surgery to improve the outcome of patients at high risk of recurrence. The women were treated between January 1999 and April 2005, and blood clots developed in 141 of the women.

Patients who developed a blood clot while taking tamoxifen were nearly five times more likely to have a genetic mutation called factor V Leiden than those who didn't develop a blood clot, according to the report published online June 16 in the Journal of the National Cancer Institute.

"These data may prove useful to women who must decide between tamoxifen and an effective . . . alternate adjuvant therapy for breast cancer" that essentially doesn't cause the blood to clot, wrote Dr. Judy E. Garber, of the Dana-Farber Cancer Institute and colleagues, in the news release from the journal's publisher.

Alternatives, she said, might include aromatase inhibitors for postmenopausal women and gonadotropin-releasing hormone analogs or oophorectomy -- the surgical removal of an ovary or ovaries -- for premenopausal women.

More information

The U.S. National Cancer Institute has more about tamoxifen.



-- Robert Preidt



SOURCE: Journal of the National Cancer Institute, news release, June 16, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene mutation increases thromboembolism risk in women taking tamoxifen
2. Gene Mutations Offer Clues to Autoimmune Disorders
3. Pitt researchers discover gene mutation linked to lymphatic dysfunction
4. Gene Mutation Linked to Congenital Heart Disease
5. Single Lung Tumor Contains 50,000 Mutations
6. New research indicates that DNA sequence itself influences mutation rate
7. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Gene Mutations Up Risk for Cancer in Opposite Breast
10. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
11. Parkinsons Linked to Genetic Mutation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Offers Clues to Tamoxifen-Blood Clot Link
(Date:8/17/2017)... ... August 17, 2017 , ... Centrifugation is more than just spinning. Like ... we can no longer do without. And just like a car, there are a ... In this webinar, attendees will learn about the most important safety aspects while using ...
(Date:8/16/2017)... ... August 16, 2017 , ... The next Patient Care Academy at ... , Students who successfully complete the seven-week long Patient Care Academy are eligible to ... average starting salary for a CNA in Kalamazoo is $24,428.* , As a CNA, ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... ... product data and images announced today that it was acquired by Advantage Solutions. ... solution for product information. IX-ONE’s members include the industry’s leading suppliers, brokers, distributors ...
(Date:8/16/2017)... , ... August 16, 2017 , ... ... partnerships through affiliations and de novo development, today announced Cumberland Skin Surgery ... Cumberland Skin Surgery and Dermatology, with offices in both Hermitage and Lebanon, Tennessee, ...
(Date:8/16/2017)... ... August 16, 2017 , ... LabRoots , the leading provider of educational ... is excited to announce Andrew Ly as the winner of the LabRoots Summer Textbook ... , Ly, who is in his third year at the University of California, ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: DPLO ... as president, effective Aug. 7, 2017. ... pursue other interests and will serve as president emeritus during ... served us in multiple leadership roles since he joined Diplomat ... and has provided decisive, strategic leadership which continues to benefit ...
(Date:8/3/2017)... , Aug. 3, 2017  Opioid addiction and other ... up healthcare costs and threatening outcomes, were problems taken ... and IVD industry that support them, met this week. ... researcher said that drugs of abuse, procalcitonin and acute ... at the organization,s 69th meeting in San ...
(Date:8/1/2017)... 2017   CerSci Therapeutics , a non-opioid drug ... , has received notice from the National Institute on ... (NIH) that it has been awarded a Direct-to-Phase II ... in 2017 with an additional $1,000,000 to follow in ... application of their lead non-opioid drug candidate CT-044 to ...
Breaking Medicine Technology: