Navigation Links
Gene Mutation Offers Clues to Tamoxifen-Blood Clot Link

Women who developed embolism during cancer treatment more likely to have variant, study shows

THURSDAY, June 17 (HealthDay News) -- Researchers have identified a gene mutation that increases the risk of blood clots in women taking the anti-cancer drug tamoxifen after surgery for early-stage breast cancer.

Tamoxifen is widely used for patients with hormone receptor-positive breast cancer, but previous studies have shown that it increases the risk of blood clots, according to background information in a news release about the new study.

The study included 412 women, median age 64, who received tamoxifen as "adjuvant" treatment for stage I, II or IIIA breast cancer. In cancer therapy, an adjuvant treatment is one used after surgery to improve the outcome of patients at high risk of recurrence. The women were treated between January 1999 and April 2005, and blood clots developed in 141 of the women.

Patients who developed a blood clot while taking tamoxifen were nearly five times more likely to have a genetic mutation called factor V Leiden than those who didn't develop a blood clot, according to the report published online June 16 in the Journal of the National Cancer Institute.

"These data may prove useful to women who must decide between tamoxifen and an effective . . . alternate adjuvant therapy for breast cancer" that essentially doesn't cause the blood to clot, wrote Dr. Judy E. Garber, of the Dana-Farber Cancer Institute and colleagues, in the news release from the journal's publisher.

Alternatives, she said, might include aromatase inhibitors for postmenopausal women and gonadotropin-releasing hormone analogs or oophorectomy -- the surgical removal of an ovary or ovaries -- for premenopausal women.

More information

The U.S. National Cancer Institute has more about tamoxifen.

-- Robert Preidt

SOURCE: Journal of the National Cancer Institute, news release, June 16, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene mutation increases thromboembolism risk in women taking tamoxifen
2. Gene Mutations Offer Clues to Autoimmune Disorders
3. Pitt researchers discover gene mutation linked to lymphatic dysfunction
4. Gene Mutation Linked to Congenital Heart Disease
5. Single Lung Tumor Contains 50,000 Mutations
6. New research indicates that DNA sequence itself influences mutation rate
7. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Gene Mutations Up Risk for Cancer in Opposite Breast
10. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
11. Parkinsons Linked to Genetic Mutation
Post Your Comments:
Related Image:
Gene Mutation Offers Clues to Tamoxifen-Blood Clot Link
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “America On ... Christian identity. “America On The Brink” is the creation of published author, William ... several great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today announced that it will release third-quarter 2017 ... 26, 2017, and will follow with a conference call ... a.m. Eastern Time. To participate on the call, please ... is 94093362. A ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
Breaking Medicine Technology: