Navigation Links
Gene Mutation Offers Clues to Tamoxifen-Blood Clot Link
Date:6/17/2010

Women who developed embolism during cancer treatment more likely to have variant, study shows

THURSDAY, June 17 (HealthDay News) -- Researchers have identified a gene mutation that increases the risk of blood clots in women taking the anti-cancer drug tamoxifen after surgery for early-stage breast cancer.

Tamoxifen is widely used for patients with hormone receptor-positive breast cancer, but previous studies have shown that it increases the risk of blood clots, according to background information in a news release about the new study.

The study included 412 women, median age 64, who received tamoxifen as "adjuvant" treatment for stage I, II or IIIA breast cancer. In cancer therapy, an adjuvant treatment is one used after surgery to improve the outcome of patients at high risk of recurrence. The women were treated between January 1999 and April 2005, and blood clots developed in 141 of the women.

Patients who developed a blood clot while taking tamoxifen were nearly five times more likely to have a genetic mutation called factor V Leiden than those who didn't develop a blood clot, according to the report published online June 16 in the Journal of the National Cancer Institute.

"These data may prove useful to women who must decide between tamoxifen and an effective . . . alternate adjuvant therapy for breast cancer" that essentially doesn't cause the blood to clot, wrote Dr. Judy E. Garber, of the Dana-Farber Cancer Institute and colleagues, in the news release from the journal's publisher.

Alternatives, she said, might include aromatase inhibitors for postmenopausal women and gonadotropin-releasing hormone analogs or oophorectomy -- the surgical removal of an ovary or ovaries -- for premenopausal women.

More information

The U.S. National Cancer Institute has more about tamoxifen.



-- Robert Preidt



SOURCE: Journal of the National Cancer Institute, news release, June 16, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene mutation increases thromboembolism risk in women taking tamoxifen
2. Gene Mutations Offer Clues to Autoimmune Disorders
3. Pitt researchers discover gene mutation linked to lymphatic dysfunction
4. Gene Mutation Linked to Congenital Heart Disease
5. Single Lung Tumor Contains 50,000 Mutations
6. New research indicates that DNA sequence itself influences mutation rate
7. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Gene Mutations Up Risk for Cancer in Opposite Breast
10. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
11. Parkinsons Linked to Genetic Mutation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Offers Clues to Tamoxifen-Blood Clot Link
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... RIDGE, Ill. and INDIANAPOLIS ... of students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship ... The 2016 scholarship winners, announced today online at ... to let type 1 diabetes stand in the way ... Diabetes has supported the Foundation,s scholarship program since 2012, ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
Breaking Medicine Technology: