Navigation Links
Gene Mutation May Up Risks of Endometrial Cancer
Date:5/27/2009

Marker indicates aggressiveness of the disease, study finds,, ,,

WEDNESDAY, May 27 (HealthDay News) -- A genetic marker for aggressive endometrial cancer has been identified by U.S. researchers, who said their finding could lead to more targeted and risk-appropriate treatments.

The researchers, from the Washington University School of Medicine in St. Louis, found that genetic mutation of the ATR gene in tumors boosts the risk of cancer recurrence and death in women with a highly aggressive form of the disease known as endometrioid endometrial cancer.

The ATR gene directs cellular responses to DNA damage, the researchers noted.

"Women whose endometrial cancers have an ATR mutation have more than four times the risk of having their cancer return," study author Dr. Israel Zighelboim, a gynecologic oncologist, said in a news release from the university. "This and similar tumor biomarkers could potentially identify those patients most in danger of recurrence and guide the development of treatments aimed at these more aggressive tumors."

ATR mutations were found in about 5 percent of the 248 endometrioid endometrial tumor samples analyzed by the researchers. Women with ATR mutations were 4.29 times more likely to have the cancer recur after treatment and 3.88 times more likely to die.

The study appears online in the Journal of Clinical Oncology.

Zighelboim and his research colleagues plan to see if the prognostic value of ATR mutations can be confirmed in a larger group of women and to investigate the association between ATR mutations and treatment response after cancer recurrence.

More information

The American Cancer Society has more about endometrial cancer.



-- Robert Preidt



SOURCE: Washington University School of Medicine in St. Louis, news release, May 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening
2. First noninvasive technique to accurately predict mutations in human brain tumors
3. Gene Mutation Doubles Risk of Aggressive Colon Cancer in Blacks
4. Increase in P53 mutation linked to advanced colorectal cancer in blacks
5. Mutation of BRCA gene influences womens views of preventive mastectomy
6. Women with BRCA mutation, or worry, most likely to undergo prophylactic mastectomy
7. Men With BRCA Gene Mutations Unaware of Cancer Risks
8. Researchers identify ALS gene mutation
9. Gene Mutation Linked to Inherited ALS
10. 2 gene mutations linked to most common brain cancers -- and longer survival
11. Genetic Mutations Linked to Deadly Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation May Up Risks of Endometrial Cancer
(Date:5/24/2017)... ... 2017 , ... If you are thinking of a visit to San Francisco , fall ... the perfect time to visit. , Business Architecture Associates is pleased to offer 5 days ... as a 4-½ day package for individuals, and as 4-½ day corporate package for up ...
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – with a ... lifting weights for strength training and exercise or simply lifting heavy objects, advises Dr. ... position is everything,” Dr. Chang says. “Improper technique in lifting anything heavy or an ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... and medical device sectors, today announced the winners of its 3rd Annual ELITE ... the most influential people in the healthcare industry today. , Out of more ...
(Date:5/23/2017)... Newport Beach, CA (PRWEB) , ... May 23, 2017 , ... ... Capital Partners was honored to serve earlier this month as a Guest Speaker and ... by the British Royal Family and Common Purpose. , Walter Schindler ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... chat as a standard feature on its secure clinical communication platform. The platform ... to video depending on the type and urgency of a situation. , ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), ... 100,000 square feet to its Welch Allyn campus. ... commitment to bring more than 100 new jobs to ... Allyn has maintained a significant presence for more than ... new positions, a large portion of which will be ...
(Date:5/4/2017)... SAN DIEGO , May 4, 2017  The ... Clinical and Scientific Meeting— OBP Medical , a leading ... announced the launch of a new extra-small size and ... ER-SPEC vaginal specula. Already available in small, ... sizes makes OBP Medical,s line of single-use lighted specula ...
(Date:5/3/2017)... 3, 2017 A Catheterization Laboratory is ... healthcare facility. Commonly referred to as cath lab, ... diagnostic imaging technology to give physicians visual access ... these spaces, a team of physicians perform life-saving ... coronary intervention, congenital heart defect closure, stenotic heart ...
Breaking Medicine Technology: