Navigation Links
Gene Mutation May Up Risks of Endometrial Cancer
Date:5/27/2009

Marker indicates aggressiveness of the disease, study finds,, ,,

WEDNESDAY, May 27 (HealthDay News) -- A genetic marker for aggressive endometrial cancer has been identified by U.S. researchers, who said their finding could lead to more targeted and risk-appropriate treatments.

The researchers, from the Washington University School of Medicine in St. Louis, found that genetic mutation of the ATR gene in tumors boosts the risk of cancer recurrence and death in women with a highly aggressive form of the disease known as endometrioid endometrial cancer.

The ATR gene directs cellular responses to DNA damage, the researchers noted.

"Women whose endometrial cancers have an ATR mutation have more than four times the risk of having their cancer return," study author Dr. Israel Zighelboim, a gynecologic oncologist, said in a news release from the university. "This and similar tumor biomarkers could potentially identify those patients most in danger of recurrence and guide the development of treatments aimed at these more aggressive tumors."

ATR mutations were found in about 5 percent of the 248 endometrioid endometrial tumor samples analyzed by the researchers. Women with ATR mutations were 4.29 times more likely to have the cancer recur after treatment and 3.88 times more likely to die.

The study appears online in the Journal of Clinical Oncology.

Zighelboim and his research colleagues plan to see if the prognostic value of ATR mutations can be confirmed in a larger group of women and to investigate the association between ATR mutations and treatment response after cancer recurrence.

More information

The American Cancer Society has more about endometrial cancer.



-- Robert Preidt




'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening
2. First noninvasive technique to accurately predict mutations in human brain tumors
3. Gene Mutation Doubles Risk of Aggressive Colon Cancer in Blacks
4. Increase in P53 mutation linked to advanced colorectal cancer in blacks
5. Mutation of BRCA gene influences womens views of preventive mastectomy
6. Women with BRCA mutation, or worry, most likely to undergo prophylactic mastectomy
7. Men With BRCA Gene Mutations Unaware of Cancer Risks
8. Researchers identify ALS gene mutation
9. Gene Mutation Linked to Inherited ALS
10. 2 gene mutations linked to most common brain cancers -- and longer survival
11. Genetic Mutations Linked to Deadly Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation May Up Risks of Endometrial Cancer
(Date:6/30/2015)... ... ... Trenton Health Team has been certified by the New Jersey Department of ... State, serving the greater Trenton community. The ACO pilot is for a three-year ... collaborative structure of THT, bringing together the vast majority of Trenton’s primary and specialty ...
(Date:6/30/2015)... ... June 30, 2015 , ... Today, Grand Terrace Health Care ... Care Center.” Each year, Medicare ranks care centers around the country in an ... their needs. Grand Terrace prides itself on quality in each of Medicare’s evaluation ...
(Date:6/30/2015)... Sacramento, CA (PRWEB) , ... June 30, 2015 ... ... on YouTube titled, “University Post-Acute Rehab”. The video focuses on the rehab center’s ... Five-Star rating, indicating it provides the best quality of services available. Each patient ...
(Date:6/30/2015)... , ... June 30, 2015 , ... On June 26, ... Acne ,” listed five triggers that most people would not expect to cause ... and toothpaste. The primary causes of acne are clogged pores and bacteria ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... eyeglasses online , finally its here, http://www.express-glasses.com is proud to ... for many location, ask about shipping with DHL Express when calling or visiting ...
Breaking Medicine News(10 mins):Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 2Health News:Trenton Health Team Certified as Medicaid Accountable Care Organization 3Health News:Grand Terrace Health Care Center Announces Five-Star Rating in YouTube Video 2Health News:Patients of University Post-Acute Rehab Support Five-Star Rating in New Video 2Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2Health News:Eyeglasses Online - Express Glasses Announcing New International Shipping Using DHL 2
... infants and children in India over the past 20 years ... a new study led by researchers at the Harvard School ... births occurring between 1985 and 2005, the researchers found that ... female children, but not male children, in both the first ...
... of Medicine has developed the first web-based screening tool ... been used by soldiers returning from the wars in ... Road to Recovery Conference and Tribute in Orlando to ... brain injury is underdiagnosed, and left untreated can have ...
... a thermostatic mixer valve to control the maximum temperature ... of hot bath water and should reduce the risk ... Nottingham. The study, carried out in partnership with ... mixing valve (TMV) fitted to the hot and cold ...
... (HealthDay News) -- People enrolled in Medicare Advantage private ... plans, but a national consumer group urges a careful ... what the Medicare agency calls the Medicare Advantage Disenrollment ... only to traditional Medicare coverage administered by the federal ...
... the varicella, or chickenpox, vaccine provide excellent protection in children ... To be published in the February 1 issue of The ... two-dose vaccine regimen recommended in the United States since 2006. ... The Centers for Disease Control and Prevention (CDC) began ...
... Mozes HealthDay Reporter , TUESDAY, Jan. 4 ... in a newly identified stem cell defect, a finding ... the road, a new study reveals. Researchers say ... by which hair follicle stem cells turn into hair-producing ...
Cached Medicine News:Health News:Violence against mothers linked to 1.8 million female infant and child deaths in India 2Health News:Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury 2Health News:Thermostatic mixer valves could significantly reduce the risk of scalding in children, study finds 2Health News:Thermostatic mixer valves could significantly reduce the risk of scalding in children, study finds 3Health News:People Dropping 'Medicare Advantage' Urged to Analyze Options 2Health News:Study confirms 2 vaccine doses protect children from chickenpox 2Health News:Stem Cell Defect Might Help Spur Common Baldness 2Health News:Stem Cell Defect Might Help Spur Common Baldness 3
(Date:6/30/2015)... , June 30, 2015  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that the ... 14, 2015, from 8:00 a.m.- 1:00 pm EDT in ... The Ardelyx senior management team will present an ... compound, tenapanor, which has completed Phase 2b clinical trials ...
(Date:6/30/2015)... JERUSALEM , June 30, 2015 ... http://www.oramed.com ), a clinical-stage pharmaceutical Company focused on the ... the first patient has been screened in the Company,s ...  This U.S. based study will be performed under the ... the U.S. Food and Drug Administration (FDA). ...
(Date:6/30/2015)... 2015 /PRNewswire/ – Small Cap IR issues report. Recently, ... custom Arrayit blood card technology to Vivos, Global Genome ... Vivos offers an impervious, impenetrable and permanent DNA storage ... child on Earth, a safe and secure nuclear blast-proof, ... allow the rapid collection, separation, drying and storage of ...
Breaking Medicine Technology:Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 2Oramed Enrolls First Patient in its Phase IIb Oral Insulin Study 3Small Cap IR - Empowering the Age of Genetic Enlightenment 2
The adult blanket provides full coverage for patients of all sizes. The generous size and versatility of these blankets include extra material for the shoulders and feet. The foot drape also reduces ...
This revolutionary system combines the CSZ Head Wrap and Patient Vest for a non-invasive whole body hypothermia system. This method of cooling the patient allows for early treatment that is fast, cos...
The fabric is antistatic and non-linting and is both oil and water repellent.These superior blankets are an environmental friendly alternative to disposable blankets....
The Bair Hugger outpatient blanket makes it easy to give your patients the benefit of prewarming and enhance patient comfort during outpatient procedures....
Medicine Products: