Navigation Links
Gene Mutation May Be Key to Familial Pancreatic Cancer
Date:12/29/2011

THURSDAY, Dec. 29 (HealthDay News) -- Individuals may face a higher hereditary risk for developing pancreatic cancer if they carry abnormalities in the so-called "ATM" gene, new research reveals.

The finding, reported in an upcoming issue of Cancer Discovery, stems from genetic-sequencing work conducted among 166 pancreatic cancer patients. For comparative purposes, 190 other individuals who did not have pancreatic cancer also underwent sequencing.

The study was led by Alison Klein, an associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and director of the National Familial Pancreas Tumor Registry.

Noting that 10 percent of pancreatic cancer patients are from families in which more than one member has battled the disease, Klein pointed out in a news release from the American Association for Cancer Research that "there was significant reason to believe this clustering was due to genetics."

But she added that no previous effort had "been able to find the causative genes that explained the cluster of pancreatic cancer for a majority of these families."

Among the pancreatic cancer patients examined, four were found to have the ATM gene mutation. By contrast, none of the healthy individuals who were sequenced carried the abnormality, according to the report.

Ultimately, the finding could lead to the development of a new screening option for a disease that kills 95 percent of patients within five years of diagnosis, according to the release. Though endoscopy is under study as another possible screening tool, there are as yet no other recommended screening alternatives for the number four cause of cancer-related death.

More information

For more on pancreatic cancer, visit the U.S. National Library of Medicine.

-- Alan Mozes

SOURCE: American Association for Cancer Research, news release, Dec. 29, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Single gene mutation induces endometrial cancer
2. Genetic Mutation Linked to Prostate Cancer in Blacks
3. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
4. Study shows that mutations in 1 gene cause many cancers
5. Parkinsons Linked to Genetic Mutation
6. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
7. Gene Mutations Up Risk for Cancer in Opposite Breast
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
10. New research indicates that DNA sequence itself influences mutation rate
11. Single Lung Tumor Contains 50,000 Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation May Be Key to Familial Pancreatic Cancer
(Date:4/24/2017)... ... April 24, 2017 , ... ... work wear distributors and International relief organizations across the globe to provide effective ... offers lifestyle and work wear collections via insectshield.com . In the wake ...
(Date:4/24/2017)... ... April 24, 2017 , ... A 2-in-1 bottleless water ... place. From 101 Water Texas, here are the ways in which this technology ... continuous supply of pure, fresh, oxygenated water, with both cold and hot options. ...
(Date:4/23/2017)... ... April 23, 2017 , ... Altura Communication Solutions, ... of Cisco Select certification and SMB specialization. Altura is now qualified to ... In earning the Select Certification, Altura fulfilled the training and exam requirements for ...
(Date:4/22/2017)... ... April 22, 2017 , ... ... has named PROSHRED® Security of Philadelphia its “Woman-Owned Small Business of ... specializes in providing information destruction , recycling, and compliance services to ...
(Date:4/22/2017)... New Freedom, PA (PRWEB) , ... April 22, ... ... of healthcare experience to his role as Vice President of Sales and Business ... direction of key GPO/IDN business partner engagements, business development, and strategic planning for ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017 The Global Effective ... to 2022 report has covered and analysed the potential of ... on market size, shares and growth factors. The report identifies ... and opportunities in the global market. ... Browse 152 Tables and Figures, 6 Major Company ...
(Date:4/19/2017)... 19, 2017  New research provides evidence that an old ... to a study released today that will be presented at ... in Boston , April 22 to 28, ... of Parkinson,s disease, the oral drug levodopa has long been ... But as the disease progresses, the effects of the medication ...
(Date:4/18/2017)... Ohio , April 18, 2017  Cardinal Health ... Non-GAAP 1 fiscal 2017 earnings per share (EPS) ... and 2019.  This is in conjunction with this morning,s ... Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... from continuing operations will be at the bottom of ...
Breaking Medicine Technology: