Navigation Links
Gene Mutation May Be Key to Familial Pancreatic Cancer
Date:12/29/2011

THURSDAY, Dec. 29 (HealthDay News) -- Individuals may face a higher hereditary risk for developing pancreatic cancer if they carry abnormalities in the so-called "ATM" gene, new research reveals.

The finding, reported in an upcoming issue of Cancer Discovery, stems from genetic-sequencing work conducted among 166 pancreatic cancer patients. For comparative purposes, 190 other individuals who did not have pancreatic cancer also underwent sequencing.

The study was led by Alison Klein, an associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and director of the National Familial Pancreas Tumor Registry.

Noting that 10 percent of pancreatic cancer patients are from families in which more than one member has battled the disease, Klein pointed out in a news release from the American Association for Cancer Research that "there was significant reason to believe this clustering was due to genetics."

But she added that no previous effort had "been able to find the causative genes that explained the cluster of pancreatic cancer for a majority of these families."

Among the pancreatic cancer patients examined, four were found to have the ATM gene mutation. By contrast, none of the healthy individuals who were sequenced carried the abnormality, according to the report.

Ultimately, the finding could lead to the development of a new screening option for a disease that kills 95 percent of patients within five years of diagnosis, according to the release. Though endoscopy is under study as another possible screening tool, there are as yet no other recommended screening alternatives for the number four cause of cancer-related death.

More information

For more on pancreatic cancer, visit the U.S. National Library of Medicine.

-- Alan Mozes

SOURCE: American Association for Cancer Research, news release, Dec. 29, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Single gene mutation induces endometrial cancer
2. Genetic Mutation Linked to Prostate Cancer in Blacks
3. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
4. Study shows that mutations in 1 gene cause many cancers
5. Parkinsons Linked to Genetic Mutation
6. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
7. Gene Mutations Up Risk for Cancer in Opposite Breast
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
10. New research indicates that DNA sequence itself influences mutation rate
11. Single Lung Tumor Contains 50,000 Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation May Be Key to Familial Pancreatic Cancer
(Date:1/16/2017)... ... 2017 , ... To provide comfort and fuel during the ... category, announces a hearty and wholesome Winter Menu. Starting today, guests can enjoy ... Cranberry Crunch & Honey Parfait, Slow Cooked Smoky Chicken & Sausage Soup, and ...
(Date:1/16/2017)... New York, NY (PRWEB) , ... January 16, 2017 , ... ... the grand opening of a new showroom in East Hanover, New Jersey. , “We ... at Gym Source. “The new innovative in-store concept is designed to give clients a ...
(Date:1/16/2017)... ... ... Anybody who may be looking for a substance abuse rehabilitation program with a ... holistic treatment center for addiction located in Marne, MI. This video, which can be ... staff that visited the 2016 Recovery Palooza support event in nearby Grand Rapids. , ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... Prairie’s award-winning Reflection® brand of custom seating systems has a well-earned reputation for ... with a platform for innovation and growth in the custom seating business, which ...
(Date:1/16/2017)... ... , ... St. Louisans are well-aware of the following facts at present:, ... to be having no effect on keeping this particularly bad strain of the flu away ... coughing, sneezing, or sniffling , These facts are well-known among the team ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... Jan. 16, 2017 Summary ... to 2022", provides key market data on the North ... millions of US dollars, volume (in units) and average ... Absorptiometry (DEXA) and Quantitative Ultrasound (QUS). The report ... each of these market segements, and global corporate-level profiles ...
(Date:1/16/2017)...  Verathon ® Inc., a leading manufacturer and marketer of ... ® Spectrum TM Single-Use video laryngoscopes. The ... Ambient Light Reduction TM technology, which actively optimizes image quality. ... ... Introducing another bright idea from GlideScope(R) ...
(Date:1/16/2017)... -- When synthetic Fentanyl arrived on the streets in 2015, ... offered free samples, inviting would-be customers to test a newly-created ... The rapidly-growing demand for ... than morphine, has racked up a staggering death toll across ... dealer,s recorded fentanyl sales reveals that they have sold nearly ...
Breaking Medicine Technology: