Navigation Links
Gene Mutation Linked to Migraines, Researchers Say
Date:5/1/2013

WEDNESDAY, May 1 (HealthDay News) -- Researchers say they've identified a gene mutation associated with a typical form of migraine headache.

The causes of migraine headaches are unknown. Between 10 percent and 20 percent of people suffer from the debilitating, recurrent headaches.

For the new study, published May 1 in the journal Science Translational Medicine, researchers analyzed the genetics of two families in which migraines were common. They found that many of the migraine sufferers had either a mutation in the casein kinase I delta (CKIdelta) gene or were the children of a parent with the mutation.

In laboratory cells, the researchers found that the mutation affects production of the CKIdelta enzyme, which performs vital functions in the brain and body.

Further experiments in mice suggested more evidence of a connection between this gene mutation and migraines.

"This is the first gene in which mutations have been shown to cause a very typical form of migraine," senior investigator Louis Ptacek, a professor of neurology at the University of California, San Francisco, said in a university news release.

"It's our initial glimpse into a black box that we don't yet understand," added Ptacek, who also is an investigator at UCSF's Howard Hughes Medical Institute.

Migraines cause "huge losses in productivity, not to mention immense suffering," Ptacek said. Symptoms include a throbbing headache, hypersensitivity to sound and touch, and aura, which Ptacek described as "a visual sensation that presages the headache to come."

There are good migraine drugs available now, "but they only help some patients, some of the time," he said. "The need for better treatments is huge."

"[This research] puts us one step closer to understanding the molecular pathway to pain in migraine," he said. With a better understanding of the condition, "we can start thinking about better therapies. Certain mo
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Tumors with ALK rearrangements can harbor more mutations
2. Scientists discover gene mutation that causes children to be born without spleen
3. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
4. Blood tests can provide fuller picture of mutations in cancer than traditional biopsies do
5. Pathologists identify patterns of mutations to help inform design of future trials
6. Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
7. Immortality gene mutation identifies brain tumors and other cancers
8. First single gene mutation shown to result in type 1 diabetes
9. Gene Mutations Benefit for Ovarian Cancer Patients May Not Last: Study
10. University of Minnesota researchers discover enzyme behind breast cancer mutations
11. Some cancer mutations slow tumor growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Linked to Migraines, Researchers Say
(Date:4/18/2015)... 18, 2015 In the past few ... of changes. , "We had to run maintenance on ... changes," said Jennifer Ramirez, the PR Director. "It disrupted ... say that we are back on track after having ... process of changing phone systems which has not allowed ...
(Date:4/18/2015)... 2015 Aureus Medical Group (web: ... physical therapy jobs, has announced that it will ... Physical Therapy Association Annual Conference to be held ... Greenville, SC. , The SCAPTA Annual Conference ... products and services. , Representatives from Aureus ...
(Date:4/18/2015)... French physician and gastronome Anthelme Brillat-Savarin ... he uttered, “Tell me what you eat, and I ... cope with stress or sadness has often been attributed ... otherwise. Data collected from their Emotional Eating Test ... eating, but for different reasons. , Collecting data from ...
(Date:4/17/2015)... April 18, 2015 Rosetta Radiology is ... rounding out their list of diagnostic imaging services. This ... patients on the Upper East Side of Manhattan. , ... full capacity. The addition of PET-CT, combined with Rosetta’s ... the ability to work with patients through several stages ...
(Date:4/17/2015)... Alcohol and Violence , The National ... drinking and driving has been the focus of much ... the link between alcohol and crime received less public ... and sexual assault, and their relationship to alcohol have ... million adults in America were drinking alcohol at the ...
Breaking Medicine News(10 mins):Health News:TheBeautyPlace.com Temporary Number Available 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3
... Company to Also Present Clinical Data at, ... Upcoming Scientific Meeting ... DDSS ) today announced the publication of Extended Release ... the May 2009 issue of the journal Psychiatry (Edgemont) (Volume 6, ...
... German . , When cells cannot carry out ... is disease. Nanobiotechnology researchers are looking for ways to allow ... absent from the cell. This requires transport systems that can ... controlled fashion at the right moment. The transporter must be ...
... May 19 The Pharmaceutical Research and Manufacturers of ... in the research pipeline for diabetes. The report shows ... a record 183 new diabetes medicines. The medicines listed ... trials or are awaiting approval by the U.S. Food ...
... Lilly with Medtronic delivery and glucose sensing leadership INDIANAPOLIS ... recognized names in diabetes management -Eli Lilly and Company ... MDT ) - today announced a strategic ... people with diabetes manage their blood sugar using insulin ...
... Veterinary Care Digital Imaging and Data Management Providers ... Eklin Medical Systems, a leading provider of ... Communications Systems) and practice management software (VIA(R)) for ... Thorn as the company,s West Coast ultrasound representative. ...
... improve our understanding of conditions such as epilepsy and ... University have discovered. , Research by a team ... has discovered that a person,s brain produces a unique ... looks at a visual pattern. , Importantly, the ...
Cached Medicine News:Health News:Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal 2Health News:Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal 3Health News:Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal 4Health News:Capsules encapsulated 2Health News:New Report Released in North Carolina Shows Record Number of Medicines in Development to Treat Diabetes 2Health News:New Report Released in North Carolina Shows Record Number of Medicines in Development to Treat Diabetes 3Health News:New Report Released in North Carolina Shows Record Number of Medicines in Development to Treat Diabetes 4Health News:Lilly and Medtronic Form Alliance to Provide Solutions for Diabetes Management 2Health News:Lilly and Medtronic Form Alliance to Provide Solutions for Diabetes Management 3Health News:Lilly and Medtronic Form Alliance to Provide Solutions for Diabetes Management 4Health News:Eklin Medical Systems Appoints Juan Thorn as West Coast Ultrasound Sales Representative 2Health News:'Singing brains' offers epilepsy and schizophrenia clues 2
(Date:4/16/2015)... 2015  Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ) will ... on Wednesday, May 6, 2015, following the close of the ... conference call and live webcast on the same day at ... discuss the financial results.  To access the ... the "Investors" link.  Please log onto the webcast prior to ...
(Date:4/16/2015)... Kenneth C. Frazier , chairman and chief executive officer ... the Board of the Pharmaceutical Research and Manufacturers of America ... John J. Castellani announced that he will be retiring ... to PhRMA Board Frazier formerly held the position ... and CEO of Pfizer, Inc. Also elected were George ...
(Date:4/16/2015)... YORK , April 16, 2015 An ... additional way to generate trimers from the major HIV ... could benefit future clinical development of HIV vaccine candidates ... the critical target on the surface of HIV for ... an important platform for AIDS vaccine discovery, says ...
Breaking Medicine Technology:Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 2Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 3Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 2Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 3Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 4Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 5New Method Holds Promise for HIV Vaccine Development 2
... Corporation (Nasdaq: GNBT, www.generex.com ), the leader in ... of the mouth, today announced that it has been ... Canadian Intellectual Property Office granted Canadian Patent No. 2,401,942, ... Application". This new patent increases the number ...
... International Corporation (Nasdaq: PRXL ) announced today it ... Conference in New York.  James Winschel, Senior Vice President and ... at 11:45 a.m. ET on Tuesday, October 5, 2010. ... through the "Investors" section of PAREXEL,s website at ...
Cached Medicine Technology:Generex Awarded a New Patent in Canada for its Proprietary Buccal Drug Delivery System 2Generex Awarded a New Patent in Canada for its Proprietary Buccal Drug Delivery System 3PAREXEL International to Present at William Blair Emerging Growth Stock Conference 2
... Meet All Nearpoint Testing Needs, ... Horizontal and Vertical Phoria, Binocular ... Visual Acuity Horizontal Fixation Disparity, ... Cylinder, Random Dot Stereopsis Monocular ...
Pediatric: Tumbling "E" Acuity, Binocular Balance, Supression, Fixation Disparity, Stereopsis...
Adult: Letter Acuity, Number Acuity, and Tumbling E Tests....
... is a serine protease that is,found only ... of the,acini and ducts. Normal PSA concentration ... Reports have suggested that elevated,level of whole ... useful tumor,markers in diagnosis of prostate cancers. ...
Medicine Products: