Navigation Links
Gene Mutation Linked to Migraines, Researchers Say
Date:5/1/2013

WEDNESDAY, May 1 (HealthDay News) -- Researchers say they've identified a gene mutation associated with a typical form of migraine headache.

The causes of migraine headaches are unknown. Between 10 percent and 20 percent of people suffer from the debilitating, recurrent headaches.

For the new study, published May 1 in the journal Science Translational Medicine, researchers analyzed the genetics of two families in which migraines were common. They found that many of the migraine sufferers had either a mutation in the casein kinase I delta (CKIdelta) gene or were the children of a parent with the mutation.

In laboratory cells, the researchers found that the mutation affects production of the CKIdelta enzyme, which performs vital functions in the brain and body.

Further experiments in mice suggested more evidence of a connection between this gene mutation and migraines.

"This is the first gene in which mutations have been shown to cause a very typical form of migraine," senior investigator Louis Ptacek, a professor of neurology at the University of California, San Francisco, said in a university news release.

"It's our initial glimpse into a black box that we don't yet understand," added Ptacek, who also is an investigator at UCSF's Howard Hughes Medical Institute.

Migraines cause "huge losses in productivity, not to mention immense suffering," Ptacek said. Symptoms include a throbbing headache, hypersensitivity to sound and touch, and aura, which Ptacek described as "a visual sensation that presages the headache to come."

There are good migraine drugs available now, "but they only help some patients, some of the time," he said. "The need for better treatments is huge."

"[This research] puts us one step closer to understanding the molecular pathway to pain in migraine," he said. With a better understanding of the condition, "we can start thinking about better therapies. Certain molecules might be targets for new drugs."

Ptacek said the CKIdelta gene is not the only mutation likely to be associated with migraines. "There are likely several, in different combinations in different people," he said. "This is simply the first one we've found."

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about migraines.

-- Robert Preidt

SOURCE: University of California, San Francisco, news release, May 1, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tumors with ALK rearrangements can harbor more mutations
2. Scientists discover gene mutation that causes children to be born without spleen
3. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
4. Blood tests can provide fuller picture of mutations in cancer than traditional biopsies do
5. Pathologists identify patterns of mutations to help inform design of future trials
6. Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
7. Immortality gene mutation identifies brain tumors and other cancers
8. First single gene mutation shown to result in type 1 diabetes
9. Gene Mutations Benefit for Ovarian Cancer Patients May Not Last: Study
10. University of Minnesota researchers discover enzyme behind breast cancer mutations
11. Some cancer mutations slow tumor growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Linked to Migraines, Researchers Say
(Date:10/13/2017)... Worth, TX (PRWEB) , ... October 13, 2017 ... ... financial planning agency serving communities in the greater Dallas, Miami, and Raleigh regions, ... young boy fighting to overcome a rare and deadly chromosome abnormality. , After ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International ... promote standards of excellence for the field of eating disorders, announces the opening ... 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... SAN DIEGO , Oct. 12, 2017   Divoti ... Medical Alert Jewelry up to the standard of the latest FDA ... (Launched: June 2017). Anyone in need of Medical ID ... Divoti Medical Alert Jewelry are engraved in terms of the ... ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: