Navigation Links
Gene Mutation Linked to Migraines, Researchers Say
Date:5/1/2013

WEDNESDAY, May 1 (HealthDay News) -- Researchers say they've identified a gene mutation associated with a typical form of migraine headache.

The causes of migraine headaches are unknown. Between 10 percent and 20 percent of people suffer from the debilitating, recurrent headaches.

For the new study, published May 1 in the journal Science Translational Medicine, researchers analyzed the genetics of two families in which migraines were common. They found that many of the migraine sufferers had either a mutation in the casein kinase I delta (CKIdelta) gene or were the children of a parent with the mutation.

In laboratory cells, the researchers found that the mutation affects production of the CKIdelta enzyme, which performs vital functions in the brain and body.

Further experiments in mice suggested more evidence of a connection between this gene mutation and migraines.

"This is the first gene in which mutations have been shown to cause a very typical form of migraine," senior investigator Louis Ptacek, a professor of neurology at the University of California, San Francisco, said in a university news release.

"It's our initial glimpse into a black box that we don't yet understand," added Ptacek, who also is an investigator at UCSF's Howard Hughes Medical Institute.

Migraines cause "huge losses in productivity, not to mention immense suffering," Ptacek said. Symptoms include a throbbing headache, hypersensitivity to sound and touch, and aura, which Ptacek described as "a visual sensation that presages the headache to come."

There are good migraine drugs available now, "but they only help some patients, some of the time," he said. "The need for better treatments is huge."

"[This research] puts us one step closer to understanding the molecular pathway to pain in migraine," he said. With a better understanding of the condition, "we can start thinking about better therapies. Certain molecules might be targets for new drugs."

Ptacek said the CKIdelta gene is not the only mutation likely to be associated with migraines. "There are likely several, in different combinations in different people," he said. "This is simply the first one we've found."

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about migraines.

-- Robert Preidt

SOURCE: University of California, San Francisco, news release, May 1, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tumors with ALK rearrangements can harbor more mutations
2. Scientists discover gene mutation that causes children to be born without spleen
3. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
4. Blood tests can provide fuller picture of mutations in cancer than traditional biopsies do
5. Pathologists identify patterns of mutations to help inform design of future trials
6. Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
7. Immortality gene mutation identifies brain tumors and other cancers
8. First single gene mutation shown to result in type 1 diabetes
9. Gene Mutations Benefit for Ovarian Cancer Patients May Not Last: Study
10. University of Minnesota researchers discover enzyme behind breast cancer mutations
11. Some cancer mutations slow tumor growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Linked to Migraines, Researchers Say
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
Breaking Medicine Technology: