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Gene Mutation Linked to Chemo-Resistant Colon Cancer
Date:1/4/2012

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Jan. 4 (HealthDay News) -- Some people with advanced colorectal cancer are resistant to some types of chemotherapy, and a mutation in the so-called TFAP2E gene may play a part in that resistance, German researchers report.

Knowing which patients carry the mutation might help doctors tailor treatments or develop new targets for therapy, the researchers said.

"In our study, we identified a gene which is frequently altered in colorectal cancer," said lead researcher Dr. Matthias P.A. Ebert, an assistant professor of internal medicine at the University of Magdeburg. "This genetic alteration is associated with increased resistance to chemotherapy and radiation in colorectal cancers."

The findings appear in the Jan. 5 issue of the New England Journal of Medicine.

For the study, Ebert's team analyzed how the TFAP2E gene functioned in colorectal cancer tumors.

Overall, they looked at more than 200 patients undergoing chemotherapy for advanced colorectal cancer. Among the first group of 74 patients, 38 had a mutation in this gene, the researchers found.

Mutated tumor cells in these and other patients made the cells resistant to fluorouracil, a widely used type of chemotherapy. However, the mutation did not make the tumor resistant to irinotecan or oxaliplatin, two other chemotherapy drugs, the researchers found.

In the rest of the patients after the first group, the researchers found a similar association between the TFAP2E gene mutation and tumors not responding to chemotherapy with fluorouracil.

"Chemotherapy and radiation is very helpful in the majority of patients with colon cancer and rectal cancers, respectively," Ebert said.

"If our studies are confirmed in prospective trials and by other groups, alteration of the TFAP2E gene could help identify subgroups of patients with colorectal cancer that would show good response
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