Navigation Links
Gene Mutation Key to Infertility in Male Mice
Date:10/17/2007

If same defect exists in men, it could lead to new treatments, study says,,,,

WEDNESDAY, Oct. 17 (HealthDay News) -- A defect in a gene that's essential for the formation of functioning sperm cells may cause infertility by preventing the head of sperm from being able to penetrate an egg.

The finding, by researchers at the University of North Carolina at Chapel Hill, was based on research with mice. But it might one day lead to treatments for infertility in men, the scientists said.

In experiments with mice that lacked the crucial gene, Jhdm2a, the scientists found that the rodents didn't produce many mature sperm cells, and the sperm that were produced had abnormally shaped heads and nonfunctioning tails.

"We found how the expression of genes that are important for the maturation of sperm is controlled," said lead researcher Yi Zhang, a professor of biochemistry and biophysics at the UNC School of Medicine. The Jhdm2a gene is responsible for packing DNA in the head of a sperm cell, making the head like a hard ball that can penetrate an egg, he explained.

Even though the study mice had a sex drive, they weren't able to impregnate female mice, Zhang said. "The sperm can't swim and cannot enter the egg," he said.

The findings were published online Oct. 17 in the journal Nature.

Because the Jhdm2a gene has an effect on the development of functional sperm, it might be a target for new infertility treatments for men, Zhang added. He and his colleagues are looking at infertility patients to see if the same mutation is present in human males. But it's still not clear if a mutation in the gene is to blame for infertility in men, he said.

"If we identify this mutation in infertile patients, then we may find a way to make the patient's sperm mature," Zhang said. "We don't know yet -- it's just a possibility," he added.

It appears that Jhdm2a plays an important role in the late stages of sperm cell development. The mice lacking this gene had smaller testes, low sperm count, were infertile, and their sperm had abnormally shaped heads and immotile tails, Zhang said.

More information

For more on infertility, visit the U.S. National Library of Medicine.



SOURCES: Yi Zhang, Ph.D., researcher, Howard Hughes Medical Institute, University of North Carolina School of Medicine, Chapel Hill; Oct. 17, 2007, Nature, online


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Minor mutations in HIV virus
2. Mutation connected to Osteoporosis
3. Stem Cells Have Few Mutations
4. Genetic mutation to the fountain of youth discovered
5. Gene Mutation Causes Ovarian Failure
6. Gene mutation identified for inherited pain syndrome
7. Mutations in NOTCH1 cause an early developmental defect in the aortic valve
8. Success of HIV may depend in its mutations
9. BRAC2 mutations is also linked with cancers in men
10. Familial Breast cancer without gene mutation not found to cause ovarian cancer.
11. A Word Of Caution: Routine Screening For Breast Cancer Mutation Not Advisdable
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... Maryland (PRWEB) , ... June 24, 2016 , ... ... Angels is actively feeding the Frederick area economy by obtaining investment capital for ... over the past 2½ years that have already resulted in more than a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... LAS VEGAS , June 26, 2016 ... movement to value-based care operating models within the health ... that enable greater financial efficiency , Deloitte offers ... address the key business issues impacting efficient cost optimization: ... alignment , These services facilitate better outcomes and ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: