Navigation Links
Gene Mutation Is Linked to Heart Muscle Disease
Date:7/15/2009

Findings shed light on understanding of dilated cardiomyopathy

WEDNESDAY, July 15 (HealthDay News) -- Gene mutations that cause heart muscle disease and chronic heart failure in some children and adults with dilated cardiomyopathy have been identified by researchers.

Dilated cardiomyopathy -- the most common cause of heart failure in young people and the most common reason for a heart transplant -- is a condition in which the heart becomes weakened and enlarged and is no longer able to pump blood efficiently.

The researchers screened 208 people and identified three variants of the ANKRD1 gene that were associated with dilated cardiomyopathy. According to their study, which appears online and in the July 21 print issue of the Journal of the American College of Cardiology, the ANKRD1 gene encodes a protein that plays a role in the structure and function of the heart.

"Our study indicates that variants in ANKRD1 result in dysfunction of the contraction apparatus and signaling machinery of the heart -- the method by which cells communicate to influence heart function," Dr. Jeffrey Towbin, co-director of the Heart Institute and director of cardiology at Cincinnati Children's Hospital Medical Center, said in a hospital news release. "This clarifies the mechanisms by which these inherited mutations cause disease in a subset of dilated cardiomyopathy patients."

He said the finding "provides us with a better understanding of the causes and mechanisms involved in the development of this disease and will enable better genetic testing and new treatments to be devised to improve outcomes of this serious disease."

More information

The American Heart Association has more about dilated cardiomyopathy.



-- Robert Preidt



SOURCE: Cincinnati Children's Hospital Medical Center, news release, July 13, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene Mutations May Cause Rare Neonatal Diabetes
2. Gene Mutation Linked to Parkinsons Disease
3. Research shows how genetic mutation causes epilepsy in infants
4. Gene Mutation Key to Infertility in Male Mice
5. Overlooked Mutation Can Spur HIV Drug Resistance
6. OHSU Cancer Institute researcher discovers what fuels certain cancer mutation
7. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
8. BRCA1 Mutation Prevalent Among Hispanic, Younger Black Women
9. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
10. BRCA Mutations Dont Raise Breast Cancer Risk Equally
11. Genetic Mutations Boost Prostate Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Is Linked to Heart Muscle Disease
(Date:1/20/2017)... ... ... Word: Chocolate Biscuit”: a biographical account following a man who went on to support his ... Marlyn Ivey, born in Lynn Haven, Florida and at the age of 5, his family ... age, he joined the Navy and got married right out of boot camp. , ...
(Date:1/20/2017)... ... 20, 2017 , ... “Knowledge is God’s Lighthouse”: a moving and colorful ... Lighthouse” is the creation of published author, Gene Gaapf, a retired truck driver, and ... “I have been writing since high school and have many different titles,” Gaapf mentions ...
(Date:1/19/2017)... ... ... Next week after January 20th, the fear for many is that the ... needs of over 30 million. Many interviews with Dr. Carol Francis at the Los ... were suppose to prioritize. Interviews provided below. , Among those present was ...
(Date:1/19/2017)... ... , ... WhoHaha , a digital media company dedicated to creating and ... produce a three-part video series that uses humor to highlight ways to improve heart ... AHA’s Healthy For Good™ movement, which is designed to inspire all Americans to make ...
(Date:1/19/2017)... Plains, NJ (PRWEB) , ... January 19, 2017 ... ... board certified dermatologist by the American Board of Dermatology and fellowship trained Mohs ... of the National Institutes of Health, Dr. Li completed his internship in internal ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Report Details What can be expected ... to grow at the fastest rates? This visiongain report ... opportunities and prospects. Our 190-page report provides 124 ... in the industry and the future market prospects. Our ... all the major categories of the ophthalmic devices market. ...
(Date:1/19/2017)... 19, 2017 This report on the opioid ... scenario of the global market. Large number of chronic ... chronic constipation is a major side effect of consumption ... novel targeted therapy has been prescribed to treat opioid ... targeted medicines, and growing awareness about the therapy are ...
(Date:1/19/2017)... , Jan. 19, 2017 Accuray Incorporated (Nasdaq: ... and TomoTherapy® Systems continue to set the bar for ... highest composite overall user satisfaction rating among radiation treatment ... 2016 MD Buyline Market Intelligence Briefing™. The most recent ... composite ratings among industry peers for 11 of the ...
Breaking Medicine Technology: