Navigation Links
Gene Mutation Increases Drug Toxicity, Rejection Risk in Pediatric Kidney Transplants
Date:2/18/2009

Study Suggests Genetic Approach to Personalized Screening of Anti-Rejection Drug Dosing

CINCINNATI, Feb. 18 /PRNewswire-USNewswire/ -- Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at higher risk for side effects, including compromised white blood cell count or organ rejection, according to new research.

Published online Feb. 18 by the Nature journal Clinical Pharmacology and Therapeutics, the study suggests this genetic approach could also help physicians tailor personalized anti-rejection drug doses to prevent adverse reactions, said senior investigators Alexander A. Vinks, Pharm.D., Ph.D., and Jens Goebel M.D., of Cincinnati Children's Hospital Medical Center.

"There are better ways than just giving standard doses of these drugs, and in due course these types of technologies will be available worldwide to help patients," said Dr. Vinks, director of the Division of Clinical Pharmacology and the Pediatric Pharmacology Research Unit at Cincinnati Children's. "This pilot study shows personalized and prospective MMF dosing and monitoring may be feasible to reduce the high incidence of drug toxicity in children without compromising the drug's protective effects against kidney graft rejection."

MMF, or Mycophenolate Mofetil, is an immunosuppressive agent commonly used to prevent rejection in organ transplants, particularly in kidney transplants. After taken orally, the drug is quickly processed by the body into active form. During this time, patients with a specific point mutation in the gene that helps break down the drug, UGT, metabolize the drug slower. This point mutation, called UGT1A9-331, causes overexposure and adverse side effects in the affected children, the study concluded. UGT encodes the drug's main metabolizing enzyme in the body, uridine diphosphate-glucuronosyl tr
'/>"/>

SOURCE Cincinnati Children's Hospital Medical Center
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Gene Mutation Tied to Majority of Cases of Mental Retardation
2. The Bachmann-Strauss Dystonia & Parkinson Foundation: New Study Identifies Gene Mutations as Cause of Dystonia in Amish-Mennonite Families
3. Gene mutations increase risk for aggressive prostate cancer
4. 60 Million Worldwide Carry Heart Disease Mutation
5. Scientists identify new congenital neutropenia syndrome and causative gene mutation
6. Gene Mutation Tied to Inherited Fatal Lung Disease
7. Yeast mimics severity of mutations leading to fatal childhood illness
8. Mutations common to cancer and developmental disorder examined in a novel disease model
9. UBC researchers discover gene mutation that causes eye cancer
10. Gene Mutation in Dalmatians Sheds Light on Kidney Stones in Humans
11. Gene Mutation May Cause Some Cases of Seasonal Affective Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... of Hematology (ASH) will present the Society,s highest honor, ... in Hematology, to Kanti R. Rai, MD, of the ... for his 50-year career combining landmark clinical leukemia research, ... care. , The Wallace H. Coulter Award for ... who has been a vital contributor to the field ...
(Date:7/22/2014)... Washington DC (PRWEB) July 22, 2014 ... in USA, launched updated payment app for Forte Payment ... credit, debit and ACH payments on iPhone, iPod and ... 2013 and has been recently updated by SIMpalm. This ... support; app is currently supported on iOS 4.3 and ...
(Date:7/22/2014)... American Conference on Lung Cancer (LALCA 2014) will be ... , Lung Cancer is still the leading cause of ... on the success of the previous conferences in Chile, ... discuss the science and advances in the treatment and ... Latin America in particular. , With tobacco being the ...
(Date:7/22/2014)... The Pennsylvania judge overseeing hundreds ... in the Philadelphia Court of Common Pleas won’t ... cases alleging the medication caused plaintiffs to develop ... In an Order dated July 18, 2014, Judge ... certify the matter for an immediate appeal to ...
(Date:7/22/2014)... The market for botulinum neurotoxin (BoNT) ... owing to novel medical indications created and due to ... societies where physical appearance is extremely valued. Although the ... competitors, new companies and technologies are setting ground for ... put the price of 1st-gen products under pressure, only ...
Breaking Medicine News(10 mins):Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 2Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 3Health News:ASH honors Kanti R. Rai, M.D., with Coulter Award for Lifetime Achievement 4Health News:SIMpalm Launched Updated Forte Mobile Payment App on iPhone and iPad for Its Client 2Health News:SIMpalm Launched Updated Forte Mobile Payment App on iPhone and iPad for Its Client 3Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuit News: Pennsylvania Judge Won’t Reconsider Denial of Punitive Damages for Risperdal Gynecomastia Plaintiffs, Bernstein Liebhard LLP Reports 4Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 2Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 3Health News:Botulinum Neurotoxins Marketplace Analysed in New La Merie Publishing Report Available at MarketPublishers.com 4
... Annual Meeting & OTO EXPO of the American Academy of ... meeting of ear, nose, and throat doctors in the world, ... more than 305 scientific research sessions, 594 posters, and several ... a unique opportunity for journalists from around the world to ...
... graduate student Brian Zikmund-Fisher was forced into the toughest choice ... few years or endure a bone marrow transplant that could ... now an assistant professor at the University of Michigan School ... After nine months of blood transfusions, a bone marrow match ...
... By Dennis Thompson HealthDay Reporter , TUESDAY, ... smile. What wasn,t to like about a break in the ... and fun? Now fast-forward to your adult life. What ... Some medical experts think it,s not only a good idea ...
... to indicate a racial disparity in the psychological abuse ... African American seniors could be twice as likely to ... also revealed that African American elders could be up ... the survey results in The Gerontologist, the ...
... there may be a way to predict, based on individual ... the investigational new drug tivozanib. This is possible, the ... a new way of creating animal tumor models that mimic ... these studies, they have found a single biomarker that may ...
... Jewish Health has received a US patent for a ... bubble to deliver an antigen and DNA adjuvant. Chairman ... Health Professor of Medicine Steve Dow, PhD, developed the ... of an infectious organism, generally work fine by themselves. ...
Cached Medicine News:Health News:2010 AAO-HNSF miniseminars: Wednesday, Sept. 29, 2010 2Health News:2010 AAO-HNSF miniseminars: Wednesday, Sept. 29, 2010 3Health News:Doctors need to help patients prepare better for health decisions 2Health News:Doctors need to help patients prepare better for health decisions 3Health News:Adding Recess to the Workday Gains Backers 2Health News:Adding Recess to the Workday Gains Backers 3Health News:Adding Recess to the Workday Gains Backers 4Health News:African-American seniors at twice the risk for mental abuse, 5 times for financial exploitation 2Health News:African-American seniors at twice the risk for mental abuse, 5 times for financial exploitation 3Health News:Novel biomarker may predict response to new VEGF receptor inhibitor 2
(Date:7/22/2014)... July 22, 2014 Cumberland Pharmaceuticals Inc. (NASDAQ: ... 2014 financial results after the market closes on Tuesday, ... webcast will be held on Tuesday, August 5, 2014, ... To participate in the call, please dial ... A rebroadcast of the teleconference will be available for ...
(Date:7/22/2014)... 22, 2014 The National Space Biomedical Research ... for Space Radiation Research (CSRR) under the leadership of ... Associate Professor of Pharmaceutical Sciences within the University of ... of Radiation Health. She is located in ... team of investigators working across four U.S. institutions, to ...
(Date:7/22/2014)... Resources Group finds that the market for interventional cardiology (IC) ... stagnant at a value of around $80 million through 2022. ... volumes are growing faster in Canada ... United States and Europe . ... penetration of PCI procedures relative to coronary artery bypass graft ...
Breaking Medicine Technology:Cumberland Pharmaceuticals To Announce Second Quarter 2014 Financial Results On August 5, 2014 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 3The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 2The Canadian Interventional Cardiology Device Market Will Remain Relatively Stagnant Through 2022 at Around $80 Million 3
... Meghan Lopresto, VP, Sales Force Automation Analytics at The ... Vaccines, will be co-presenting their expertise in interactive selling ... in Philadelphia. The conference is a ... and medical affairs professionals to discuss novel approaches to ...
... -- In 2012, Fi Asia-China, Hi & Ni ... food & beverage shows in China, will take ... Shanghai New International Expo Centre (SNIEC), organized by ... ) (Logo: http://www.prnasia.com/sa/2010/04/19/20100419602891.jpg ) ...
Cached Medicine Technology:The CementBloc and Novartis Vaccines to Jointly Present Top Considerations in Interactive Selling at the 11th Annual iPharmaConnect 2Fi Asia-China, Hi & Ni China is Ready for Return on June 2012 in Shanghai 2
For support, strength and control in your interventions, the RunWay Guide Catheter's large lumen and high-performance design represents a new era in guide catheters....
For support, strength and control in your interventions, the RunWay Guide Catheter's large lumen and high-performance design represents a new era in guide catheters....
... 20-year history, the VOYAGER RX Dilatation Catheter ... outcomes. It combines a new low profile, ... shaft,more flexible markers, and short taper balloon ... tortuous anatomy with even greater confidence, opening ...
... developed over Guidants 20-year history, the VOYAGER ... for successful treatment outcomes. It combines a ... a lower profile shaft,more flexible markers, and ... cross tight and tortuous anatomy with even ...
Medicine Products: