Navigation Links
Gene Mutation Found in One of Four Cases of Deadly Brain Cancers
Date:12/22/2010

WEDNESDAY, Dec. 22 (HealthDay News) -- A gene mutation that is present in one of every four patients with glioblastoma brain cancer has been identified by researchers.

The mutation -- a gene deletion known as NFKBIA -- contributes to tumor development, promotes resistance to treatment and significantly worsens the chances of survival of patients with glioblastoma, the most common and deadly type of adult brain cancer, senior author Dr. Griffith Harsh, a professor of neurosurgery at the Stanford University School of Medicine, said in a Stanford news release.

For this study, researchers analyzed several hundred tumor samples collected from glioblastoma patients and found NFKBIA deletions in 25 percent of the samples.

The study, which appears online Dec. 22 in the New England Journal of Medicine, is the first to link the NFKBIA deletion with glioblastoma.

Previous research has found that defects in NFKBIA -- normally present on chromosome 14 -- are linked with a wide range of cancers, including melanoma, multiple myeloma, Hodgkin's lymphoma, and breast, lung and colon cancers.

It was already known that a genetic defect in the coding for epidermal growth factor receptor (EGFR), a cell-surface receptor for a hormone known as epidermal growth factor, plays a role in about one-third of glioblastoma cases. In these cases, there are either too many copies of EGFR or its receptor is stuck in the "on" position, so it sends out messages for cells to multiply continuously. This can spark the development of tumors.

Patients with NFKBIA or EGFR abnormalities have significantly shorter survival times than glioblastoma patients with tumors that have neither defect, the researchers noted.

The discovery may aid the development of targeted therapies. "If we can determine that a patient's glioblastoma has the NFKBIA deletion, we can target that tumor for treatment" with drugs that take the gene deletion into account, according to study principal investigator Dr. Markus Bredel. Background material for the study notes that some drugs, such as bortezomib, which now treat other cancers, may even have that capability, and an early-stage clinical trial using bortezomib for glioblastoma is currently taking place at Northwestern.

More information

The U.S. National Cancer Institute has more about adult brain tumors.

-- Robert Preidt

SOURCE: Stanford University, news release, Dec. 22, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Single gene mutation induces endometrial cancer
2. Genetic Mutation Linked to Prostate Cancer in Blacks
3. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
4. Study shows that mutations in 1 gene cause many cancers
5. Parkinsons Linked to Genetic Mutation
6. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
7. Gene Mutations Up Risk for Cancer in Opposite Breast
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
10. New research indicates that DNA sequence itself influences mutation rate
11. Single Lung Tumor Contains 50,000 Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Found in One of Four Cases of Deadly Brain Cancers
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- One of Australia,s successful biotechnology scientists, ... new biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ("Noxopharm"). ... list on the ASX. Noxopharm is a clinic-ready company ... Phase 1 clinical study later this year. ... biggest problems facing cancer patients - the ability of cancers to ...
(Date:6/26/2016)... June 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as ... Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) ... Daylight Time). As previously announced on May ... definitive merger agreement under which Jazz Pharmaceuticals has commenced ...
(Date:6/26/2016)... 2016  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) ... measures required to build a strong and stable market ... listed on the OTC Markets-pink current trading platform. ... "We are seeing an anomaly in market trading activities ... by the Company, but shareholders and market players as ...
Breaking Medicine Technology: