Navigation Links
Gene Mutation Found in One of Four Cases of Deadly Brain Cancers
Date:12/22/2010

WEDNESDAY, Dec. 22 (HealthDay News) -- A gene mutation that is present in one of every four patients with glioblastoma brain cancer has been identified by researchers.

The mutation -- a gene deletion known as NFKBIA -- contributes to tumor development, promotes resistance to treatment and significantly worsens the chances of survival of patients with glioblastoma, the most common and deadly type of adult brain cancer, senior author Dr. Griffith Harsh, a professor of neurosurgery at the Stanford University School of Medicine, said in a Stanford news release.

For this study, researchers analyzed several hundred tumor samples collected from glioblastoma patients and found NFKBIA deletions in 25 percent of the samples.

The study, which appears online Dec. 22 in the New England Journal of Medicine, is the first to link the NFKBIA deletion with glioblastoma.

Previous research has found that defects in NFKBIA -- normally present on chromosome 14 -- are linked with a wide range of cancers, including melanoma, multiple myeloma, Hodgkin's lymphoma, and breast, lung and colon cancers.

It was already known that a genetic defect in the coding for epidermal growth factor receptor (EGFR), a cell-surface receptor for a hormone known as epidermal growth factor, plays a role in about one-third of glioblastoma cases. In these cases, there are either too many copies of EGFR or its receptor is stuck in the "on" position, so it sends out messages for cells to multiply continuously. This can spark the development of tumors.

Patients with NFKBIA or EGFR abnormalities have significantly shorter survival times than glioblastoma patients with tumors that have neither defect, the researchers noted.

The discovery may aid the development of targeted therapies. "If we can determine that a patient's glioblastoma has the NFKBIA deletion, we can target that tumor for treatment" with drugs that take the gene deletion into account, according to study principal investigator Dr. Markus Bredel. Background material for the study notes that some drugs, such as bortezomib, which now treat other cancers, may even have that capability, and an early-stage clinical trial using bortezomib for glioblastoma is currently taking place at Northwestern.

More information

The U.S. National Cancer Institute has more about adult brain tumors.

-- Robert Preidt

SOURCE: Stanford University, news release, Dec. 22, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Single gene mutation induces endometrial cancer
2. Genetic Mutation Linked to Prostate Cancer in Blacks
3. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
4. Study shows that mutations in 1 gene cause many cancers
5. Parkinsons Linked to Genetic Mutation
6. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
7. Gene Mutations Up Risk for Cancer in Opposite Breast
8. Gene Mutation Ups Risk of Sudden Death in People with Epilepsy
9. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
10. New research indicates that DNA sequence itself influences mutation rate
11. Single Lung Tumor Contains 50,000 Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Found in One of Four Cases of Deadly Brain Cancers
(Date:2/8/2016)... ... February 08, 2016 , ... ... states in the U.S. require dental technicians to be certified or obtain continuing ... industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists and ...
(Date:2/7/2016)... ... February 07, 2016 , ... Women's Excellence staff, in all four locations, wore ... Wear Red Day is the first Friday each February and a day to bring ... in 3 deaths among women each year – more than all cancers combined. Go ...
(Date:2/7/2016)... ... 2016 , ... Dr. Todd Hobgood , certificated in ... surgical expertise. Technically known as deoxycholic acid or previously as ATX-101, Kybella® ... for reduction of fat below the chin (aka the “double chin”). Medication side ...
(Date:2/6/2016)... ... ... US Sports Camps is proud to sponsor the Bay Area Disc Association's ... leaders, ultimate organizations, and coaches from around the US. The theme for this year’s ... of Youth and Education, describes this year YUCC as “an important conversation we must ...
(Date:2/6/2016)... , ... February 06, 2016 , ... Shark Finds ... announce the launch of a new DRTV campaign with Belly Bands. , Having a ... everything from sprays to puppy pads and find nothing works, get Belly Bands, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Feb. 8, 2016   GS1 US will ... guide them through GS1 Standards implementation to address the ... Unique Device Identification (UDI) rule. Scott ... Beth Gibson , senior director industry development, medical devices, ... director, GS1 US --> Scott ...
(Date:2/8/2016)... Feb. 8, 2016 Nueterra, the ... specialized in the development of equity partnerships ... it has divided its interests between two ... Capital will continue the founding company,s private ... operate a national system of integrated provider ...
(Date:2/8/2016)... Pa. , Feb. 8, 2016   ... November Research Group (NRG),s pharmacovigilance technology services ... system-related consulting services and an Oracle Argus Specialized ... services to Life Sciences companies. ... and expands HighPoint,s life sciences capabilities and provides ...
Breaking Medicine Technology: