Navigation Links
Gene Mutation Could Be Key to Rare Blood Vessel Disease
Date:7/22/2009

Finding may lead to new treatments, researcher says

WEDNESDAY, July 22 (HealthDay News) -- Mutations in a protein called thrombomodulin, which is involved in blood clotting and preventing cell damage, may be the cause of some atypical HUS, a new Canadian study suggests.

The finding might lead to new therapies for this rare disease, researchers say. There are about 300 children affected by it in the United States, and it can be fatal, according to the Foundation for Children with Atypical Hemolytic-Uremic Syndrome (aHUS).

"Identification of all of the mechanisms leading to aHUS will hopefully lead to new treatments that are currently lacking and urgently needed," said lead researcher Dr. Edward M. Conway, director of the Centre for Blood Research at the University of British Columbia Life Sciences Centre in Vancouver.

HUS is a serious condition, most often seen in children. The major cause of the disorder is damage to the endothelial cells that form the inner lining of blood vessels, Conway explained. This leads to clotting of the blood in small blood vessels, and deforming of red blood cells, causing anemia; and loss of platelets, which causes bleeding and inadequate blood supply, particularly to the kidneys, which leads to kidney failure, he said.

The trigger for the endothelial cell injury in HUS is most often a toxin that is released from bacteria after ingestion of contaminated water or food, Conway said.

"There is, however, a more rare 'atypical' form of HUS that is not induced by the bacterial toxin," he said. "In contrast to the more common form, patients with aHUS often do poorly."

Approximately 25 percent of patients with aHUS die, and about 50 percent end up needing dialysis for kidney failure, according to Conway, who added, "aHUS is seen in individuals who have, in their blood, excess activation of the so-called complement system."

The complement system is a c
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Study Shows a Link Between Schizophrenia & Genetic Mutations
2. Gene Mutation Is Linked to Heart Muscle Disease
3. JNCI news brief: Hepatitis B virus mutations may predict risk of liver cancer
4. Cancer Researchers Link DICER1 Gene Mutation to Rare Childhood Cancer
5. New Cancer Drug Fights Tumors in Those With BRCA Mutations
6. Clarient Launches New Gene Mutation Test to Help Select Therapy for Non-Small Cell Lung Cancer
7. USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma
8. Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service
9. Gene Mutation May Up Risks of Endometrial Cancer
10. Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening
11. First noninvasive technique to accurately predict mutations in human brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutation Could Be Key to Rare Blood Vessel Disease
(Date:11/28/2014)... 28, 2014 Top10inaction.com, a popular product ... Best Styling Tools For Hair in 2014 at ... such as T3 Featherweight 2 Hair Dryer, ghd Eclipse ... listed. , With the significant increase of awareness on ... but also home-used hair styling tools become necessities in ...
(Date:11/27/2014)... November 28, 2014 One of ... dentistry. The market for implant dentistry comprises dental ... The global market for dental care is bifurcated ... The dental equipment segment is composed of large ... contents at: http://www.researchmoz.us/global-dental-market-report-2014-edition-report.html , The worldwide ...
(Date:11/27/2014)... 2014 Recently, iFitDress.com, a reliable company ... items to its assortment of black cocktail dresses ... to 70% off. Some models are priced under $50. ... cocktail dresses can enjoy a low shipping fee before ... special for its clients. The business has promised to ...
(Date:11/27/2014)... November 28, 2014 Today, Digital-Signage-China.com adds 2 ... and launched a digital signage media player promotion for Dec. ... can expect a shopping wave in April, and this promotion ... client cannot find her desired models on our website, she/he ... designs here” , The new models come in the latest ...
(Date:11/27/2014)... This is a professional and in-depth ... industry with a focus on the Chinese market. The ... the Bronchoscopes manufacturers and is a valuable source of ... the industry. , Firstly, the report provides a basic ... manufacturing technology. Then, the report explores the international and ...
Breaking Medicine News(10 mins):Health News:T3 Featherweight 2 Hair Dryer Is Named As Best Hair Styling Tool 2Health News:Dental Market Research Report 2014 - Global Industry Size, Share, Trends, Growth, Retail Sales Value and Forecast by Researchmoz.us 2Health News:Dental Market Research Report 2014 - Global Industry Size, Share, Trends, Growth, Retail Sales Value and Forecast by Researchmoz.us 3Health News:Beautiful Black Cocktail Dresses Offered by Top Dress Supplier iFitDress.com 2Health News:Digital-Signage-China.com Offers Big Discounts On Its New Digital Signage Media Players 2Health News:Bronchoscopes Industry 2019 Forecasts for Global and China Region in New Research Report at ReportsnReports.com 2Health News:Bronchoscopes Industry 2019 Forecasts for Global and China Region in New Research Report at ReportsnReports.com 3
... sparked new fears over the safety of Scottish farmed salmon ... two portions a year.// ,Researchers at the University ... the health benefits of eating Scottish fish are outweighed by ... and what the fish is fed determine whether the health ...
... is an improvement in the motor symptoms of patients ... cell implants from the human retina, according to a ... who suffer from the neurodegenerative disorder require the levodopa ... used for treating tremors and spasms. The levodopa medication ...
... bird flu tsar will be appointed for Scotland for coordinating ... who will be responsible for giving his expert advice will ... opinion that the virus can mutate to spread rapidly among ... post has not been revealed. The person appointed will dedicate ...
... inquest is being conducted into the death of Rene Anderson ... cannabis-based drug. The Sativex drug is derived from the plant, ... drug was administered to Rene Anderson for relieving her of ... reported to have developed psychosis after the administration of the ...
... Research Institute have found that supplementation of GSK-3 Inhibitors ... immune cells which fights against cancer cells.// Researchers have ... the treatment of Alzheimer’s and diabetes to boost the ... ,Cancer chemotherapy apart from being cytotoxic ...
... women after abortion which was headed by Anne Nordal Broen ... of the women who had induced abortions were many times ... had miscarriage. ,The study included women from the ... abortions (80).They were asked to fill in questionnaires and also ...
Cached Medicine News:Health News:Salmon's own diet sure to affect yours 2
(Date:11/26/2014)... 26, 2014 Investor-Edge has initiated coverage ... ), Horizon Pharma PLC (NASDAQ: HZNP ), Endocyte ... JNJ ), and Theravance Inc. (NASDAQ: ... accessed at: http://investor-edge.com/register . On Tuesday, November ... the Dow Jones Industrial Average edged 0.02% lower, to finish ...
(Date:11/26/2014)... PORTLAND, Oregon , November 26, 2014 ... or fascia of the organ protrudes through the wall of ... weak muscle area at birth are some of the causes ... inguinal, umbilical, hiatal, femoral, and incisional. An inguinal hernia is ... area. An umbilical hernia is found in the area of ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, Inc., ... novel therapies for infectious diseases, announced today the ... internationally recognized key opinion leader in the areas ... advisory board. Founder and Chief Executive ... believe Dr. Opal,s extensive experience investigating bacterial toxins ...
Breaking Medicine Technology:Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3
... Have Greater Concentrations of,Stem Cells, ARLINGTON HEIGHTS, Ill., ... inner thigh through liposuction was found to be,an excellent ... other areas of the body, reports a Brazilian-based study ... of the,American Society of Plastic Surgeons (ASPS). This is ...
... review that concluded late yesterday, the Board of ... that it,had discontinued the PI-88 phase 3 study ... develop its existing portfolio of compounds and,the company ... through Merger & Acquisition activity., The strategic ...
Cached Medicine Technology:Want a Reason to Love Your Lower Belly Fat? It's Rich in Stem Cells 2Progen Terminates PATHWAY Trial & Confirms Focus on Potential High Value Molecules and M&A 2Progen Terminates PATHWAY Trial & Confirms Focus on Potential High Value Molecules and M&A 3
Hibbs Retractor with sharp teeth. Used for deep soft tissue retraction....
A general purpose instrument for use around the femur and acetabulum....
The Wire Cutters are designed to cut Kirschner wires up to 2.5 mm diameter easily and smoothly. They are particularly useful for external fixation applications. The Wire Cutters shear fixation wires ...
The double action wire cutter has both side and end cutting capabilities....
Medicine Products: