Navigation Links
Gene May Influence Breast Cancer-Estrogen Link
Date:9/17/2007

Targeting this DNA might improve treatment, researchers say

MONDAY, Sept. 17 (HealthDay News) -- U.S. researchers say they've found a gene that plays a crucial role in the ability of breast cancer cells to respond to estrogen.

The finding that transcription factor AP2C (TFAP2C) controls multiple pathways of estrogen signaling may lead to improved therapies for hormone-responsive breast cancer and may help explain differences in the effectiveness of current treatments, said a team from the University of Iowa.

The study was published in the Sept. 15 issue of the journal Cancer Research.

"Estrogen binds to estrogen receptors and triggers a cascade of events including gene regulation," study leader Dr. Ronald Weigel, professor and head of surgery at the university's college of medicine, said in a prepared statement.

"We found that elimination of TFAP2C from the cell causes all of those cascades that we associate with estrogen to go away," he said. "The treated cancer cells were not able to respond to estrogen by any normal pathway."

Silencing TFAP2C inhibited tumor growth in mice. It also halted expression of another estrogen receptor called GPR30, found at the cancer cell membrane.

"Targeting this gene may be a better way to develop drugs to treat hormone-responsive breast cancers, because it targets multiple different pathways," Weigel said.

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: University of Iowa, news release, Sept. 15, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Genetic influence in menopause
2. Movies Influence Youngsters To Drink
3. Diet Can Influence Allergic Skin Reactions
4. Birth weight may be influenced by genes
5. Many factors influence sexual potency
6. Influence of diet on allergic Reactions
7. Smoking may be influenced by Parents
8. Alcoholism Influenced By Both Genetics & Family Environment
9. Hunger Found To Influence Taste
10. Body Weight Found To Influence PSA Levels
11. Depressed Mothers Found To Influence Their Child’s Behavio
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... While it’s often important to take certain medications during the night, ... has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX ... eliminates the need to turn on a light when taking medication during the night, ...
(Date:10/13/2017)... ... 2017 , ... Lori R. Somekh, founder of the Law Office of ... elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain ... to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017 OBP ... self-contained, illuminating medical devices, today announced regulatory approval ... Surveillance Agency (or Agência Nacional de Vigilância Sanitária ... single-use, cordless surgical retractor with integrated LED light ... access, illumination and exposure of a tissue pocket ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology: