Navigation Links
Gene May Help Spur Obsessive-Compulsive Disorder
Date:8/22/2007

Mice with the mutation exhibited fearful, repetitive behaviors, researchers say

WEDNESDAY, Aug. 22 (HealthDay News) -- Mice with a particular gene mutation behave much like humans with obsessive-compulsive disorder (OCD), scientists report.

The rodents have a genetic flaw that prevents their brain cells from producing a protein called SAPAP3, according to a Duke University Medical Center-led study.

SAPAP3 plays an important role in the transmission of signals between brain cells.

Mice lacking this protein were afraid to move out of the corner of their cages and compulsively groomed their faces until they bled.

"The mice that could not produce this protein exhibited behaviors similar to that of humans with OCD, a compulsive action coupled with increased anxiety," team leader Guoping Feng, a Duke molecular geneticist, said in a prepared statement.

When the mice were given a replacement dose of SAPAP3 in an area of the brain called the striatum (which controls the planning and execution of movement), many of them showed improvement. The same was true when they were given drugs (selective serotonin reuptake inhibitors -- SSRIs) used to treat humans with OCD.

The study, which is published in the Aug. 23 issue of the journal Nature, may offer important clues about a possible mechanism for OCD, which affects about two percent of the world's population.

More information

The American Academy of Family Physicians has more about OCD.



-- Robert Preidt



SOURCE: Duke University, news release, Aug. 22, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Guidelines For Better Management Of Obsessive-Compulsive Disorder
2. Obsessive-Compulsive Disorder Is Familial
3. Eating disorder in Diabetic girls lead to eyesight damage.
4. Individuals with sleep related breathing disorders more prone to heart disease
5. Eating disorders are hereditary
6. Low testosterone levels lead to eating disorders
7. Eating disorder... a survey
8. Suicide risk in panic disorder
9. FDA approves new device to treat womens bleeding disorder
10. Genetic disorder related with sleep patterns
11. Control of anger disorder connected to Brain Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 24, 2017 , ... “End Time GPS”: a dauntless and enlightened study ... Time GPS” is the creation of published author, Wesley Gerboth, a World War II ... and space-vehicle projects. Now, at age ninety-one, he shares the Wisdom God bestowed upon ...
(Date:3/24/2017)... ... , ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a ... to the fullest, as God intended. “The Adventures of Joey, The Dog Who Barks ... pursuing her passion for writing, especially about truth and human behavior. , Published by ...
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the ... located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the ... living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... Oklahoma City Convention Center at 10 North Broadway Avenue, will be an educational ... of relevant, practical instruction in the management of chronic pain. , Oklahoma is ...
(Date:3/23/2017)... ... ... of adults are unaware of the dangers that infectious bacteria play in mouth disease, while ... a day that dentists recommend. The ramifications of improper oral upkeep go far beyond bad ... 164 million hours of work each year due to dental issues. That is why Mediaplanet ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 23, 2017  Provectus Biopharmaceuticals, Inc. ... "Company"), a clinical-stage oncology and dermatology biopharmaceutical company, ... Financing Commitment Term Sheet (the "Definitive Financing") it ... of the Company,s stockholders, who are referred to ... a Form 8-K filed with the Securities and ...
(Date:3/23/2017)... The key factors driving the growth ... accelerating economic growth and increasing healthcare expenditure. Some of the ... expectancy of ESRD patients, rising demand for home PD treatment ... of the market is hindered by high treatment costs and ... ...
(Date:3/23/2017)... -- As a result of diagnostic technology increasing ... allergic diseases, cutting edge developments in targeted drugs ... in which pharmaceutical and biotech companies are addressing ... both a high quality meeting and a platform ... research scholars and doctors. The event will also ...
Breaking Medicine Technology: