Navigation Links
Gene May Help Predict Timing of Alzheimer's Onset
Date:7/12/2009

Discovery of TOMM40 adds to understanding of disease development

SUNDAY, July 12 (HealthDay News) -- A gene that may offer a highly accurate prediction of the risk of developing Alzheimer's disease and the age at which people will begin to show symptoms has been identified by U.S. researchers.

The TOMM40 gene may be the most highly predictive Alzheimer's gene discovered so far, said the Duke University Medical Center research team, who found that the gene could predict the age of Alzheimer's disease onset within a five- to seven-year window among people over 60.

The study was scheduled to be presented July 12 at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease, held in Vienna, Austria.

"If borne out through additional research, a doctor could evaluate a patient based on age, especially among those over age 60, their APOE genotype and their TOMM40 status, to calculate an estimated disease risk and age of onset," lead author Dr. Allen Roses, director of the Deane Drug Discovery Institute at Duke, said in a university news release.

In previous research, Roses found that apolipoprotein E (APOE) genotypes, particularly APOE4, are associated with increased risk and younger age of development of Alzheimer's disease. APOE4 accounts for about 50 percent of late-onset cases of Alzheimer's, but the cause of the remainder of cases hasn't been known.

"It now looks fairly clear that there are two major genes -- APOE4 and TOMM40 -- and together they account for an estimated 85 to 90 percent of the genetic effect," Roses said.

The Duke team is planning a five-year study of APOE genotypes and TOMM40, along with a drug trial to assess prevention or delay of Alzheimer's disease onset.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: Duke University Medical Center, news release, July 12, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Institute for Aging Research study finds delirium presentation predicts mortality
2. JNCI news brief: Hepatitis B virus mutations may predict risk of liver cancer
3. Predicting the return of prostate cancer: New Johns Hopkins study betters the odds of success
4. Air Traffic Patterns Predict Swine Flu Spread
5. Healthcare Travel Exhibition & Congress Predicts Worldwide Healthcare Travel Revenue to Hit US$100 Billion by 2012
6. MDGuidelines Offers New Predictive Modeling Feature
7. Biomarkers predict brain tumors response to therapy
8. Ovu-Trac(R) Home Test Kit From OvumOptics Predicts Ovulation with 96.2% Accuracy
9. Predicting fatal fungal infections
10. Prostate cancer test improves prediction of disease course
11. Personality May Not Predict Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene May Help Predict Timing of Alzheimer's Onset
(Date:5/26/2017)... ... ... “When the Stars Lead Home”: a poignant story of loss, determination, and ... Douglas, an avid reader who lives in the Pacific Northwest with her husband, daughter, ... Adventure Camp. She couldn’t be more grateful. , Twelve-year old Tizzy could not believe ...
(Date:5/26/2017)... ... 2017 , ... “Just What Happened in the Garden of Eden”: retells the stories of three ... the creation of published author, Penelope Colt, mother, trader, horse farmer, artist and a former ... she was three. At six, they moved to Dayton, Ohio, where Penny graduated high ...
(Date:5/24/2017)... BELLEVILLE, N.J. (PRWEB) , ... May 24, 2017 ... ... joined Clara Maass Medical Center CEO Mary Ellen, hospital employees, and town officials ... in Belleville. , The facility was developed by Rendina as part of its ...
(Date:5/24/2017)... ... 24, 2017 , ... Altec Products, Inc., a leader in enterprise ... one-day technology conference in San Diego, CA. , At nVerge 2017, Altec will ... utilize and enhance their Sage ERP solutions by providing improved visibility and control to ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Dr. Manju ... comfortable ClearCorrect orthodontics, with or without a referral. Dr. Kejriwal understands the ... she offers convenient, clear braces in Cincinnati, OH. Patients no longer need to feel ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)... 2017  The China and Canada joint ... less water, energy and detergent, and features a powerful disinfection process. ... shoebox-sized washing machine that washes and sanitizes women,s panties or babies, ... ... and does not require an external water inlet. ...
(Date:5/10/2017)... Hologic, Inc. (Nasdaq: HOLX ) announced today ... ended April 1, 2017 .   GAAP diluted earnings ... the prior year period as the sale of the ... non-GAAP diluted EPS of $0.50 increased 6.4%.  Revenue of ... terms.  Excluding the effects of blood screening and the ...
(Date:5/10/2017)... , May 10, 2017  The Corporate Whistleblower ... employees of sleep therapy clinics to call us ... therapy clinic is involved in a substantial scheme ... in hearing from an employee of a medical ... a kickback scheme to provide medical practice groups with ...
Breaking Medicine Technology: