Navigation Links
Gene May Explain Women's Heightened Lupus Risk
Date:4/2/2009

Disease-prone mice lacking this factor failed to develop common symptoms, study finds

THURSDAY, April 2 (HealthDay News) -- A gene on the X chromosome appears to be linked to lupus and might explain why women are much more likely to develop the disease than men, a new study suggests.

The gene IRAK1 may also hold a key to treating the disease. Tests by the researchers found that lupus-prone mice lacking the gene did not develop common disease symptoms such as kidney problems, production of autoimmune antibodies and white blood cell activation.

The findings were published in this week's online issue of the Proceedings of the National Academy of Sciences.

"The extensive involvement of IRAK1 in the regulation of the immune response renders its association with lupus a prime candidate for careful genetic and functional analysis," senior study author Chandra Mohan, a professor of internal medicine at the University of Texas Southwestern Medical Center at Dallas, said in a news release issued by the university.

Lupus causes a myriad of problems such as muscle pain, extreme fatigue and inflammation of the joints, skin, major organs and central nervous system. Females develop lupus 10 times more often than males, a fact researchers have theorized has to do with differences in hormones between the genders.

Future research is expected to compare the role of X-linked genes against hormonal differences in determining the likelihood of one gender being more prone to lupus.

"This first demonstration of an X chromosome gene as a disease susceptibility factor in human lupus raises the possibility that the gender difference in rates may in part be attributed to sex chromosome genes," Mohan said.

The international, multicultural genetic study found three variants of IRAK1 common in subjects whose developed lupus either as children or adults. The test on mice confirmed the link between lupus and IRAK, which previous genetic studies had suspected.

More information

The Lupus Foundation of America Inc. has more about lupus.



-- Kevin McKeever



SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, March 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Brain Hemorrhage Might Explain Natasha Richardsons Death
2. Brain Hemorrhage May Explain Natasha Richardsons Condition
3. HIPAA Amendments in Federal Stimulus Bill Explained During Critical Health Care Compliance Association Two-Part Web Conference
4. Space Research May Help Explain Salmonella Illness
5. Explaining trends in heart attack
6. Gurgle.com Explains How to Spot the Signs of Antenatal and Postnatal Depression
7. Gene Explains How High-Fructose Diets Lead to Insulin Resistance
8. Smoking behavior partially explains socioeconomic inequities in lung cancer incidence
9. Parental Distrust May Explain Lack of Black Children in Clinical Trials
10. Smoking-Low Birth Weight Link Explained in Part
11. UT Southwestern researchers identify protein that may explain healthy obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene May Explain Women's Heightened Lupus Risk
(Date:3/29/2017)... ... March 29, 2017 , ... ARI Network Services, Inc. (NASDAQ: ARIS) announced today ... websites for its network of more than 650 U.S.-based dealers. Rhino, a member of ... rotary and flail mowers and cutters, rear blades, post hole diggers, pasture renovators, tillers, ...
(Date:3/29/2017)... , ... March 30, 2017 , ... CHARM CITY RUN ... Run has announced that Mercy Medical Center will serve as the official title sponsor ... region. On Sunday, June 25, 2017, thousands of women will walk or run the ...
(Date:3/29/2017)... ... March 29, 2017 , ... AngioGenesis Labs sold 300 bottles ... AngioGenesis Labs, makers of HeartBoost, BrainBest and BeautyBest, achieved these results while doing ... an over the counter heart healthy drink, can reduce Arterial Plaque, Lower Blood ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... as it continues developing an ANSI-approved, consensus-based American National Standard for Good ... to publish the first ANSI-approved GMP standard for dietary supplements this spring, ...
(Date:3/29/2017)... ... March 29, 2017 , ... HealthCareMandA.com will host an important ... 2017, at 1:00 PM ET. A recording of the webinar will also be made ... , Home health and hospice companies are still popular targets for healthcare investors. This ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 29, 2017   Dynatronics Corporation (NASDAQ: ... of Cynthia L. McHenry (Cyndi) as ... for leading Dynatronics manufacturing, distribution, and purchasing operations ... Dynatronics, CEO Kelvyn H. Cullimore, Jr. ... search process conducted by the company as it ...
(Date:3/29/2017)... 29, 2017 On March 28, the U.S. Food and ... with relapsing forms of multiple sclerosis (MS) and primary ... approved by the FDA for PPMS. Ocrevus is an ... "Multiple sclerosis can have a profound impact ... M.D., director of the Division of Neurology Products in ...
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ - Medicure Inc. ... release financial results for the year ended December ... 26, 2017. The results are being released later ... financial statements will include the operations and balances ... 1, 2016.  This release and filing date meets ...
Breaking Medicine Technology: