Navigation Links
Gene 'Map' of Ovarian Cancer Yields New Clues to Treatment
Date:6/29/2011

ancer," Spellman explained.

Among some of the main findings:

  • There appear to be four different subtypes of HGS-OvCa, as well as four more additional related subtypes, based on the genetic scan.
  • Abnormalities present in a key gene, called TP53, were found in nearly all (96 percent) of patients diagnosed with these tumors.
  • Just over one in every five of the tumors were found to have tumor mutations in the BRCA1 and BRCA2 genes, which have long been linked to risks for both ovarian and breast cancers. In this case, patients whose cancers carried these mutations had better survival rates than those who did not.
  • Overall, specific patterns in 108 genes were also linked to poorer survival, while those for another 85 genes were linked to better outcomes. Patients with genetic activity deemed "poor" were found to have 23 percent shorter survival than those without such genetic aberrations.

The genomic scan also points to tantalizing new leads for potential treatments, the researchers said.

For example, mapping also revealed 68 genes that could become appropriate therapeutic targets for medications -- either drugs already approved for cancer treatment by the U.S. Food and Drug Administration or drugs still under development, the researchers noted.

According to the team, as many as half of all the aggressive ovarian tumors they studied might respond to drugs that focus on genetic weaknesses in the tumor to help induce cancer cell death.

Dr. Andrew Berchuck, director of the gynecologic cancer program at Duke Cancer Institute in Durham, N.C., said that the main point here is that "not all ovarian cancers are alike."

"What's basically been done here is an autopsy," he explained. "A forensic analysis of tumors. And what they find is that the molecular changes that occur in one case of ovarian cancer can be dramatically different from that of another in terms of what's gone wrong in terms of cell growth a
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Genome Map May Help Save Tasmanian Devils
2. Proteins used to map the aging process
3. Study of biomarker development in mice provides a roadmap for a similar approach in humans
4. Roadmap published for dynamic mapping of estrogen signaling in breast cancer
5. Indiana University neuroscientists map a new target to wipe pain away
6. Researchers map, measure brains neural connections
7. New route to map brain fat
8. Scientists Complete Detailed Map of Human Brain
9. NIH, USU study maps hotspots of genetic rearrangement
10. Nursing students map their way to understanding HIV
11. Scientists Map Key Structure HIV Uses to Infect Cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene 'Map' of Ovarian Cancer Yields New Clues to Treatment
(Date:10/20/2014)... (PRWEB) October 20, 2014 Women’s health ... in Obstetrics & Gynecology of Columbus, Inc., A Division ... healthcare services to more than 100,000 patients annually. Dr. ... all ages and stages of a women’s life. She ... locations in Westerville and Dublin. , Dr. Murphy ...
(Date:10/20/2014)... My Clients Plus ( http://www.MyClientsPlus.com ) today ... new module enables easy administration and routing of follow-up ... , This application allows users such as Therapists to ... to-do item to a specific client, categorize tasks the ... reminders for follow-ups. It's designed to enable easy ...
(Date:10/20/2014)... October 20, 2014 Succeed is proud to ... companies who participated in the Every Body Walk! ... public awareness project that encourages workers to be more active ... 10,000 Program, which concluded at the end of September, was ... cities and metro areas. Participating companies gave their staff ...
(Date:10/20/2014)... It’s hard to imagine what it’s like to ... around the world, it’s a reality. And while new shoes ... forced to walk barefoot on rocky terrain or sewage-lined streets ... their friends. , Buckner International's Shoes for Orphan ... in October to encourage support for Air1 and while also ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 The ... iPage ( http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the ... excellent platforms for those who want to buy ... same time. , The IT manager of Top10BestSEOHosting.com ... the most recommended suppliers for everyone. A lot ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2
... ... "California has long been regarded as the most surrogacy and egg ... heterosexual couples, gay couples and individuals worldwide realize their dream of a ... egg donation professionals regarding the opportunity to provide their services to one ...
... , , BINGHAM FARMS, Mich., July ... physician organizations who participate in the Health Information Exchange -- have ... 3rd nationally for the use of e-prescribing, and is poised to ... beyond. , , In a recently-released ...
... may help explain location of deadly builups , WEDNESDAY, July ... that supplies the brain with blood actually expands when deadly ... can lead to a fatal stroke, researchers at Wake Forest ... that the common segment shared by the right and left ...
... , , , ... reel from high unemployment and underemployment, nurses are putting in more hours than ... once the economy rebounds, according to a recent survey by AMN Healthcare, the ... survey involved nurses who during May visited NurseZone.com and RN.com, two of AMN,s ...
... there is no formula for fulfillment or guide to life ... time and again for answers to our existential questions. We ... and science continues to piece together some of the answers, ... Park and Christopher Peterson from the University of Michigan turned ...
... medical research institutions across the United States are set ... critical data about influenza vaccines, including two candidate H1N1 ... of the National Institute of Allergy and Infectious Diseases ... "With the emergence of the 2009 H1N1 influenza ...
Cached Medicine News:Health News:Surrogacy and Egg Donation Seminar with Free Egg Donation Cycle 2Health News:Surrogacy and Egg Donation Seminar with Free Egg Donation Cycle 3Health News:Surrogacy and Egg Donation Seminar with Free Egg Donation Cycle 4Health News:my1HIE Fuels the Growth of E-Prescribing in Michigan 2Health News:my1HIE Fuels the Growth of E-Prescribing in Michigan 3Health News:my1HIE Fuels the Growth of E-Prescribing in Michigan 4Health News:my1HIE Fuels the Growth of E-Prescribing in Michigan 5Health News:my1HIE Fuels the Growth of E-Prescribing in Michigan 6Health News:Carotid Artery Sections React Differently to Plaque 2Health News:Nurses Working More in Down Economy 2Health News:Life lessons: Where psychology stands on living well 2Health News:NIAID set to launch clinical trials to test 2009 H1N1 influenza vaccine candidates 2Health News:NIAID set to launch clinical trials to test 2009 H1N1 influenza vaccine candidates 3
(Date:10/17/2014)...  Hanger, Inc. (NYSE: HGR ) announced ... operations for the quarter ended September 30, 2014, on ... conference call to discuss these results is scheduled to ... 2014. Those wishing to participate should call 1-877-662-6095. A ... by dialing 1-855-859-2056 and referencing Conference ID # 91880739. ...
(Date:10/17/2014)... October 17, 2014 ... has announced the addition of the  "China ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... in China impacted ... in consumption concept, dietary habit, way of ...
(Date:10/17/2014)... DUBLIN , October 17, 2014 ... Research and Markets ( http://www.researchandmarkets.com/research/rxznjk/micro_market ) has ... Market Monitor : North American Automated ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,The ... forecast, 2008-2018 analyzes the market of ...
Breaking Medicine Technology:China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3Micro Market Monitor : North American Automated External Defibrillators (AED) Market 2
... responses on hot-button HIV/AIDS ... issues, Clinton, Edwards, Obama and Kucinich support ending ... for ... the AIDS Foundation of Chicago -- three of the,nation,s leading AIDS organizations -- polled 16 ...
... Radiologists are using a new minimally,invasive procedure to ... reduces pain from calcific tendonitis of,the rotator cuff ... at the annual meeting of the Radiological Society ... successful and inexpensive therapy for tendon,calcifications," said Luca ...
Cached Medicine Technology:Leading AIDS Groups Turn Up The Heat on '08 Presidential Candidates 2Leading AIDS Groups Turn Up The Heat on '08 Presidential Candidates 3Minimally Invasive Treatment Reduces Shoulder Pain From Tendonitis 2Minimally Invasive Treatment Reduces Shoulder Pain From Tendonitis 3
... Our new oversized wheelchair scales incorporate all ... model including automatic zero, weight recall, reweigh ... displays weight in pounds and kilos., ... patients in electric and oversized wheelchairs. The ...
This high-capacity stand-on scale provides extra sensitivity and support to patients who are unsteady on their feet. Advanced technology compensates for patient movement....
... Endo-PAT2000 is a simple and easy to ... PAT signal is recorded using Itamar Medical's ... is analyzed automatically using proprietary advanced Digital ... within seconds of completing the test. The ...
... C-peptide of insulin is the C-terminal cleavage ... prohormone to the mature insulin molecule. Although ... it does undergo significant liver or extra-renal ... circulating half-life than insulin [1]. In addition, ...
Medicine Products: