Navigation Links
Gene Linked to Schizophrenia May Reduce Cancer Risk

People who inherit a specific form of a gene that puts them on a road to schizophrenia may be protected against some forms of cancer, according to a new study by scientists at The Feinstein Institute for Medical Research.

Manhasset, NY (Vocus) January 14, 2010 -- People who inherit a specific form of a gene that puts them on a road to schizophrenia may be protected against some forms of cancer, according to a new study by scientists at The Feinstein Institute for Medical Research.

The MET proto-oncogene is activated in a variety of tumor malignancies. The gene has recently also been linked to autism and has a role in neurodevelopment, which is why Katherine E. Burdick, PhD and her colleagues decided to look for a relationship between MET and schizophrenia in their large sample of patients. Such an association may help explain the family-based data that suggest that inheriting an enhanced risk for schizophrenia reduces one’s chances of developing cancer.

In a study published in the American Journal of Psychiatry, Dr. Burdick and colleagues examined the relationship between 21 single-nucleotide polymorphisms (SNPs)) in MET and schizophrenia in 173 patients and 137 normal volunteers. They found that several varieties of MET influenced the risk for schizophrenia, as well as general cognitive ability. The authors were able to replicate their findings in a second sample of 107 patients and 112 healthy volunteers. “The results add to the growing evidence suggesting an intriguing relationship between cancer-related genes and schizophrenia susceptibility,” the scientists wrote.

It remains unclear exactly how the gene actually may increase the risk for schizophrenia while protecting against some forms of cancer. However, evidence from research on MET in autism provides some insight. Specifically, it is known that MET is activated (increased activity) when tumors develop and can increase the chance that cancer cells multiply and infiltrate other tissue.

The activation of MET during normal neurodevelopment is critical to ensure that neurons grow and migrate to position themselves correctly in the human cortex. In autism, it appears that while the brain is developing, reduced MET activity results in structural and functional changes in the brain that may increase a person’s risk for developing the disorder. The Feinstein investigators speculate that the same risk-inducing mechanism may be at play in its link to schizophrenia.


Read the full story at

Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Chemical BPA Linked to Heart Disease Risk
2. Obesity linked to common form of kidney cancer and each extra BMI point increases risk
3. Hypertension linked to dementia in older women
4. Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae
5. Air pollution linked to hospitalizations for pneumonia in seniors
6. Immune cell activity linked to worsening COPD
7. Breast Growth in Boys Might Be Linked to Plastics Chemical
8. HIV Therapy Linked to Fewer Suicides
9. Insomnia symptoms linked with medical complaints in young school-aged children
10. Five Gene Variants May Be Linked to Lung Disease
11. Bad Behavior as a Kid Linked to Early Death in Men
Post Your Comments:
Related Image:
Gene Linked to Schizophrenia May Reduce Cancer Risk
(Date:12/1/2015)... ... December 01, 2015 , ... McLean, VA., December 1, 2015 ... price per sprint agile development contract to support the National Geospatial-Intelligence Agency's (NGA) ... provides software engineering, infrastructure, as well as operations and sustainment support to the ...
(Date:12/1/2015)... Knoxville, TN (PRWEB) , ... December 01, 2015 ... ... Lessons from the Field for Effective Post-Affiliation Integration ,” addresses a main “pain ... fail to deliver the anticipated results, once a deal is signed. This ...
(Date:12/1/2015)... ... December 01, 2015 , ... With FCPX Overlay: Grit , ... control over customization, the possibilities are truly endless, all with a click of a ... position, vertical flip, horizontal flip, depth of field and more, all within Final Cut ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... on receiving the 2015 HSJ Acute Sector Innovation Award on November 18th. This ... patient care experience, and propose exciting enhancements to the medical landscape. , The ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... and Brooke Bennett are collaborating with brands across various categories through traditional and ... figures make up an elite group of Gold Medal Moms who can connect ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... MAPLE GROVE, Minn. and BASEL, ... Upsher-Smith Laboratories, Inc. (Upsher-Smith), through its wholly-owned ... for the further development of a novel, oral small ... cell-adhesion molecule that may be effective in the treatment ... Phase II clinical development. --> ...
(Date:11/30/2015)... TOKYO , 1 décembre 2015 ... plus grande exposition et conférence d,Asie ... médicaux et sur l,industrie manufacturière, se ... du 20 au 22 avril ... - Photo - ...
(Date:11/30/2015)... 1, 2015 ... "Endometriosis - Pipeline Review, H2 2015" market ... therapeutic pipeline of Endometriosis and helps enhance ... strategies to gain competitive advantage. It strengthens ... MOAs to produce first-in-class and best-in-class products. ...
Breaking Medicine Technology: