Navigation Links
Gene Linked to Schizophrenia May Reduce Cancer Risk
Date:1/15/2010

People who inherit a specific form of a gene that puts them on a road to schizophrenia may be protected against some forms of cancer, according to a new study by scientists at The Feinstein Institute for Medical Research.

Manhasset, NY (Vocus) January 14, 2010 -- People who inherit a specific form of a gene that puts them on a road to schizophrenia may be protected against some forms of cancer, according to a new study by scientists at The Feinstein Institute for Medical Research.

The MET proto-oncogene is activated in a variety of tumor malignancies. The gene has recently also been linked to autism and has a role in neurodevelopment, which is why Katherine E. Burdick, PhD and her colleagues decided to look for a relationship between MET and schizophrenia in their large sample of patients. Such an association may help explain the family-based data that suggest that inheriting an enhanced risk for schizophrenia reduces one’s chances of developing cancer.

In a study published in the American Journal of Psychiatry, Dr. Burdick and colleagues examined the relationship between 21 single-nucleotide polymorphisms (SNPs)) in MET and schizophrenia in 173 patients and 137 normal volunteers. They found that several varieties of MET influenced the risk for schizophrenia, as well as general cognitive ability. The authors were able to replicate their findings in a second sample of 107 patients and 112 healthy volunteers. “The results add to the growing evidence suggesting an intriguing relationship between cancer-related genes and schizophrenia susceptibility,” the scientists wrote.

It remains unclear exactly how the gene actually may increase the risk for schizophrenia while protecting against some forms of cancer. However, evidence from research on MET in autism provides some insight. Specifically, it is known that MET is activated (increased activity) when tumors develop and can increase the chance that cancer cells multiply and infiltrate other tissue.

The activation of MET during normal neurodevelopment is critical to ensure that neurons grow and migrate to position themselves correctly in the human cortex. In autism, it appears that while the brain is developing, reduced MET activity results in structural and functional changes in the brain that may increase a person’s risk for developing the disorder. The Feinstein investigators speculate that the same risk-inducing mechanism may be at play in its link to schizophrenia.

###

Read the full story at http://www.prweb.com/releases/Schizophrenia-met/Feinstein-Institute/prweb3452274.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Chemical BPA Linked to Heart Disease Risk
2. Obesity linked to common form of kidney cancer and each extra BMI point increases risk
3. Hypertension linked to dementia in older women
4. Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae
5. Air pollution linked to hospitalizations for pneumonia in seniors
6. Immune cell activity linked to worsening COPD
7. Breast Growth in Boys Might Be Linked to Plastics Chemical
8. HIV Therapy Linked to Fewer Suicides
9. Insomnia symptoms linked with medical complaints in young school-aged children
10. Five Gene Variants May Be Linked to Lung Disease
11. Bad Behavior as a Kid Linked to Early Death in Men
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Linked to Schizophrenia May Reduce Cancer Risk
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... Ill. (PRWEB) , ... October ... ... Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer ... healthcare professionals on guideline updates for the primary prevention of cardiovascular diseases ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at ... towards children of all ages; it is a non-competitive, non-timed event, which is all ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... 2017 Janssen Biotech, Inc. (Janssen) announced today ... the U.S. Food and Drug Administration (FDA) for the ... the treatment of moderately to severely active rheumatoid arthritis ... are needed to further evaluate the safety of sirukumab ... "We are ...
(Date:9/19/2017)... LOUISVILLE, Ky. , Sept. 19, 2017   ZirMed ... and predictive analytics, today announced that it has been ranked ... the Black Book™ Rankings 2017 User Survey. ZirMed ... software solution for large hospitals and medical centers over 200 ... in Black Book,s healthcare technology user survey history. ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 ... performance ratings for global supply chains, has published the first annual edition ... CSR performance of more than 20,400 companies evaluated by EcoVadis, based on ... 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
Breaking Medicine Technology: