Navigation Links
Gene Linked to Lung Cancer Risk in Non-Smokers
Date:3/22/2010

Discovery could provide target for future treatments, researchers say

MONDAY, March 22 (HealthDay News) -- Researchers have identified gene variations linked with an increased risk for lung cancer in people who have never smoked.

The international research team analyzed DNA from more than 1,000 people with lung cancer and cancer-free people who had never smoked and found strong evidence that two variations in a gene called GPC5 were associated with lung cancer in people who had never smoked. The variations reduce expression of GPC5, the study authors explained.

Further investigation revealed that GPC5 expression levels were 50 percent lower in lung cancer tissue from people who had never smoked, compared with lung tissue from cancer-free non-smokers.

The findings suggest that GPC5 could be a new target for further research and drug development and could be used to identify non-smokers at high risk for lung cancer.

The study findings are published online in The Lancet Oncology.

"Even though this study reports a two-fold reduction in GPC5 expression in [lung cancer] tissues compared to matched normal controls, it is far from clear how reduced GPC5 expression could predispose individuals to lung cancer," Dr. Ramaswamy Govindan, of Washington University School of Medicine in St. Louis, wrote in an editorial accompanying the study. "More studies are needed to confirm these preliminary observations in the tumor samples from those with no history of tobacco smoking."

More information

The U.S. National Cancer Institute has more about lung cancer risk.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, March 21, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Gene is linked to lung cancer development in never-smokers
2. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
3. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
4. Cellular pathway could provide evidence of how cancer and obesity are linked
5. Impulsive-antisocial personality traits linked to a hypersensitive brain reward system
6. Long-Term Use of Osteoporosis Drugs Linked to Fractures
7. Obesity linked to poor colon cancer prognosis
8. Survey Reveals Health Insurance and Access to Care Not So Closely Linked
9. NIAID media availability: Food allergy-related disorder linked to master allergy gene
10. Pre-Diagnosis Diet Linked to Ovarian Cancer Survival
11. Hormone replacement therapy linked to increased lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own ... others prefer to read it, and some people don't like it at all. FindaTopDoc ... what they found: , Erotic literature can give readers a taste of their deepest, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ensuring meat products have ... highlight the importance of correctly using a meat thermometer. The videos feature University ... research on consumer food safety habits. Dr. Bruhn explains the variety of meat ...
(Date:6/23/2017)... West Palm Beach, FL (PRWEB) , ... June 23, 2017 , ... ... June 19, in Pinecrest, Florida. This is MD Now’s 28th facility overall and marks ... 12301 S. Dixie Highway, located one mile North of The Falls shopping mall. The ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... American Farmer, ... winning series, which is slated to air fourth quarter 2017. American Farmer airs Tuesdays ... Hansen, a Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after a ...
(Date:6/23/2017)... ... 23, 2017 , ... Jusino Insurance Services, a locally owned ... greater Chicago metropolitan area, is embarking on a charity drive in conjunction with ... Founded in 1897, Hephzibah Children’s Association is one of the oldest social services ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)...  NxStage Medical, Inc. (Nasdaq:  NXTM), a leading medical technology company ... demonstrating positive biochemical outcomes related to more frequent hemodialysis ... will be presented at the ERA-EDTA Congress being held ... . The research was conducted by ... Europe (KIHDNEy) Cohort team ...
(Date:5/30/2017)... TEL AVIV, Israel , May 30, 2017 /PRNewswire/ ... clinical stage pharmaceutical Company specializing in the development ... management will present a company overview at three ... The 7th Annual LD Micro Invitational: ... Date:                     ...
(Date:5/24/2017)... 2017  ivWatch LLC today announced the launch ... to enable seamless integration of ivWatch,s groundbreaking IV ... pumps and other devices. By integrating ivWatch technology ... help health care customers deliver a higher level ... IV therapy. "The ivWatch OEM Board ...
Breaking Medicine Technology: