Navigation Links
Gene Linked to Lung Cancer Risk in Non-Smokers
Date:3/22/2010

Discovery could provide target for future treatments, researchers say

MONDAY, March 22 (HealthDay News) -- Researchers have identified gene variations linked with an increased risk for lung cancer in people who have never smoked.

The international research team analyzed DNA from more than 1,000 people with lung cancer and cancer-free people who had never smoked and found strong evidence that two variations in a gene called GPC5 were associated with lung cancer in people who had never smoked. The variations reduce expression of GPC5, the study authors explained.

Further investigation revealed that GPC5 expression levels were 50 percent lower in lung cancer tissue from people who had never smoked, compared with lung tissue from cancer-free non-smokers.

The findings suggest that GPC5 could be a new target for further research and drug development and could be used to identify non-smokers at high risk for lung cancer.

The study findings are published online in The Lancet Oncology.

"Even though this study reports a two-fold reduction in GPC5 expression in [lung cancer] tissues compared to matched normal controls, it is far from clear how reduced GPC5 expression could predispose individuals to lung cancer," Dr. Ramaswamy Govindan, of Washington University School of Medicine in St. Louis, wrote in an editorial accompanying the study. "More studies are needed to confirm these preliminary observations in the tumor samples from those with no history of tobacco smoking."

More information

The U.S. National Cancer Institute has more about lung cancer risk.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, March 21, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Gene is linked to lung cancer development in never-smokers
2. Study: Low Levels of Vitamin D Linked to Higher Rates of Asthma in African American Kids
3. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
4. Cellular pathway could provide evidence of how cancer and obesity are linked
5. Impulsive-antisocial personality traits linked to a hypersensitive brain reward system
6. Long-Term Use of Osteoporosis Drugs Linked to Fractures
7. Obesity linked to poor colon cancer prognosis
8. Survey Reveals Health Insurance and Access to Care Not So Closely Linked
9. NIAID media availability: Food allergy-related disorder linked to master allergy gene
10. Pre-Diagnosis Diet Linked to Ovarian Cancer Survival
11. Hormone replacement therapy linked to increased lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Viejo, California (PRWEB) , ... June 27, 2016 , ... ... are fully customizable inside of Final Cut Pro X," said Christina Austin - CEO ... another unique style. Final Cut Pro X users can now reveal the ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... strategic partnership with Connance, a healthcare industry leader providing predictive analytics to ... technology combine to provide health systems, hospitals and ambulatory surgical centers with ...
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... ... 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic ... World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. ... some of the world’s leading providers of cereal and other breakfast foods. Its residents ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) ... Improvements Act of 1976, as amended ("HSR"), with respect ... Nasdaq: CPXX ) expired effective June 24, ... As previously announced on May 31, 2016, Jazz Pharmaceuticals ... which Jazz Pharmaceuticals has commenced a tender offer for ...
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
Breaking Medicine Technology: