Navigation Links
Gene Linked to Inflammatory Arthritis Also Raises Heart Risks
Date:2/7/2008

British study found HLA-DRB1 increased chances of dying from cardiovascular causes

THURSDAY, Feb. 7 (HealthDay News) -- A gene called HLA-DRB1 that's associated with an increased risk of developing inflammatory arthritis may also increase the chances of premature death from cardiovascular disease (CVD), a British study finds.

People with rheumatoid arthritis (an autoimmune disease) tend to die younger, and largely from CVD, according to background information in the study, which looked at 1,022 people with inflammatory polyarthritis, including 751 people with rheumatoid arthritis (RA).

During the study period, 242 (24 percent) of the patients died, and CVD was the cause of death in 76 (31.4 percent) of those patients.

The researchers, led by Dr. Tracey M. Farragher at the University of Manchester, investigated whether genetic variants associated with increased risk of RA might also increase the risk of death from CVD. Their report was published in the February issue of Arthritis & Rheumatism.

They found evidence that implicates HLA-DRB1 genotypes, already associated with RA susceptibility and severity, as a predictor of premature death from CVD in patients with inflammatory arthritis.

The researchers said that, for RA patients in particular, having the shared epitope (SE) -- a group of HLA-DRB1 alleles with kindred amino acid traits -- plus anti-cyclic citrullinated peptide (anti-CCP) antibodies and being a current smoker is an especially lethal combination.

This is the first study to link the HLA-DRB1 genotypes with premature death, particularly from CVD, among people with inflammatory arthritis. Farragher said the findings "raise the possibility of a targeted strategy to prevent CVD in these patients" and reinforces the danger of smoking for people with a genetic predisposition for arthritis.

More information

The Arthritis Foundation has more about rheumatoid arthritis.



-- Robert Preidt



SOURCE: Arthritis & Rheumatism, news release, Jan. 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
3. Immune deficiency linked to a type of eye cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Clinical depression linked to abnormal emotional brain circuits
6. Air pollution linked to cardiovascular risk indices in healthy young adults
7. High pollution linked to poor lung function growth in children in Mexico City
8. Early Weight Loss in Women Linked to Dementia
9. Vitamin Es lack of heart benefit linked to dosage
10. Sugary Sodas High in Diabetes-Linked Compound
11. RA Drugs Linked to Slight Skin Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Linked to Inflammatory Arthritis Also Raises Heart Risks
(Date:5/25/2016)... Pines, FL (PRWEB) , ... ... ... West has received the American Heart Association/American Stroke Association's Get With The ... designation. , This achievement, a second for Memorial Healthcare System, recognizes ...
(Date:5/25/2016)... ... ... The Georgia State University College of Law new building at 85 Park Place ... annual award recognizes projects, programs, individuals and organizations that have significantly contributed toward the ... and the balance between the old and the new. , “Winning a 2016 Award ...
(Date:5/25/2016)... Netherlands (PRWEB) , ... May 25, 2016 , ... A ... freedom of movement to motion capture, all by utilizing a common Wi-Fi network and ... users to transmit data from any location with Wi-Fi, and use a mobile device ...
(Date:5/25/2016)... ... ... One Florida-based plastic surgeon’s enthusiasm is proving to be contagious among a ... 13th on Vanity Fair. In fact, as the article explains, more than a few ... than 800,000 Snapchat fans. Commenting on this trend, Dr. Michael Salzhauer, also known as ...
(Date:5/25/2016)... , ... May 25, 2016 , ... The Bank of ... Biomedical Technology Program to help provide veterans a pathway to employment and successful careers ... a $20,000 check to Nick Hallack, President and CEO of Medisend, parent organization and ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... auf den Markt gebracht, die es Ärzten erlaubt, ... überall zu behandeln: MDLinking kombiniert Live Streaming mit ... sicheren Umfeld zu kommunizieren. Mediziner in Europa, Afrika, ... haben sich bereits für die Plattform registriert. ...
(Date:5/24/2016)... , May 24, 2016 ARANZ ... for the healthcare sector, has been named the Coretex Hi-Tech ... Awards 2016. Dr Bruce Davey , CEO ... our team.  It,s really good to be recognised for the ... Our products are used in 35 countries around the world ...
(Date:5/24/2016)... 2016 Los innovadores de ... mundo, introduce catéteres para la intervención de extremidades ... compañía global especializada en el suministro de soluciones ... cartera incluyendo productos para tratar la enfermedad arterial ... son los dispositivos de primera entrada de la ...
Breaking Medicine Technology: