Navigation Links
Gene Linked to Form of Parkinson's Disease

Finding could lead to better understanding of the incurable neurological disorder

FRIDAY, March 21 (HealthDay News) -- Mutations in a gene called GIGYF2 may be directly linked to the development of Parkinson's disease in families with a history of the neurodegenerative condition, U.S. researchers report.

"These findings may ultimately help open the door to the development of new therapeutic -- and possibly even preventive -- strategies that target the underlying cause of Parkinson's disease, improving quality of life of the many people worldwide who are affected by this devastating disorder," senior author Dr. Robert J. Smith, professor of medicine at the Warren Alpert Medical School of Brown University, said in a prepared statement.

His team analyzed DNA samples from 249 Parkinson's patients with at least one first-degree relative (parent, child, sibling) with the disease, and compared them to DNA samples from 200 healthy people.

The researchers found that GIGYF2 resides on a chromosomal region called PARK11, which is linked to Parkinson's.

"Our data provides strong support for GIGYF2 as a PARK11 gene with a casual role in familial Parkinson's disease," said Smith, who is also director of the division of endocrinology and the Hallett Center for Diabetes and Endocrinology at Rhode Island Hospital.

"The next step is to zero in on this gene to learn more about its involvement in triggering Parkinson's. It will also be important to evaluate additional and larger families with Parkinson's and these genetic mutations, as well as the frequency of GIGYF2 mutations in patients with the more common, idiopathic form of the disease," he said.

The study appears online in the American Journal of Human Genetics and will be published in the April 11 print issue of the journal.

Smith and his colleagues said GIGYF2 is one of only a few genes so far linked to Parkinson's and one of just two genes known to be a common contributor to the disease, which has no known cause or cure and affects as many as one million Americans.

They noted that less than one-quarter of all Parkinson's cases are familial. But findings about genes like GIGYF2 could improve understanding of the mechanisms behind Parkinson's and may help lead to new treatments for all forms of the disease, the researchers said.

They also identified a possible association between Parkinson's and insulin and the related growth hormone called insulin-like growth factor (IGF). This adds to a growing body of research linking insulin and IGF to Parkinson's, Alzheimer's and other neurodegenerative diseases.

"A better understanding of the link between insulin or IGF and Parkinson's may lead us to new treatment strategies for Parkinson's and also new insights into the connection between diabetes and nervous system disorders," Smith said.

More information

We Move has more about Parkinson's disease.

-- Robert Preidt

SOURCE: Brown University, news release, March 20, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
3. Immune deficiency linked to a type of eye cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Clinical depression linked to abnormal emotional brain circuits
6. Air pollution linked to cardiovascular risk indices in healthy young adults
7. High pollution linked to poor lung function growth in children in Mexico City
8. Early Weight Loss in Women Linked to Dementia
9. Vitamin Es lack of heart benefit linked to dosage
10. Sugary Sodas High in Diabetes-Linked Compound
11. RA Drugs Linked to Slight Skin Cancer Risk
Post Your Comments:
Related Image:
Gene Linked to Form of Parkinson's Disease
(Date:11/27/2015)... ... ... Herpes-only dating community in the world, revealed that over 50% of its members are under ... under the age of 50 – or 67% of the population - are infected with ... infection . , "The data shocks us highly!" said Michelle Li, Co-Founder of the ...
(Date:11/27/2015)... ... , ... A simply groundbreaking television series, "Voices in America", which is hosted ... array of issues that are presently affecting Americans. Dedicated to providing the world with ... changing the subjects consumers focus on, one episode at a time. , In ...
(Date:11/27/2015)... ... 2015 , ... CBD College is proud to announce that on ... accreditation to its Diagnostic Medical Sonography program. CBD College is honored to join this ... colleges and universities in the state of California make the cut. CBD College is ...
(Date:11/27/2015)... ... 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock Posters, announces ... This is one of Joplin's most famous and beautiful concert posters. The concert was ... in Ann Arbor. The According to Hawley, "It is hard to believe that Joplin's ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, ... choose to buy during the Black Friday and Cyber Monday massage chair sales ... search the Internet high and low to find the best massage chair deals, they ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Nov. 27, 2015  Lannett Company, Inc. (NYSE: ... completed the acquisition of Kremers Urban Pharmaceuticals Inc. ... global biopharmaceuticals company UCB S.A. (Euronext: UCB). ... has acquired KU from UCB for total consideration ... including a customary working capital adjustment, a deduction ...
(Date:11/26/2015)... UTRECHT , Países Bajos, November 26, 2015 /PRNewswire/ ... con la terapia fotodinámica de Bremachlorin para el cáncer ... combina la inmunoterapia con la terapia fotodinámica de Bremachlorin ... Un nuevo enfoque combina la inmunoterapia con la ...   Clinical Cancer Research . --> ...
(Date:11/26/2015)... --> --> ... find optimal contrast weighting of MRI for patients with ... a research agreement with SyntheticMR in order to use SyMRI ... is possible to generate multiple contrast images from a single ... left, thus making it possible to both fine tune images ...
Breaking Medicine Technology: