Navigation Links
Gene Linked to 'Dry' Macular Degeneration
Date:8/27/2008

Study also uncovers risks associated with treating 'wet' form of the eye disease

WEDNESDAY, Aug. 27 (HealthDay News) -- Scientists from the United States and China have identified the first gene directly associated with the onset of severe "dry" macular degeneration, one of two forms of age-related macular degeneration that currently threatens the vision of up to nine million older Americans.

The discovery, based on work with both human and mice cells, centers on a specific immune system protein called TLR3. Although helpful in fending off illness when confronted with certain viral infections, this molecule, when routinely activated, was also found to raise the risk for "dry" macular degeneration by attacking infected retinal cells.

But, the study authors also found a genetic silver lining in the form of a mutated version of TLR3 -- a so-called "inactive" or "less active" TLR3 -- that suppresses this retinal death process, seemingly protecting people from the eye disease.

"This represents a major step forward in our understanding of the dry form of macular degeneration," said study co-author Dr. Kang Zhang, a professor of ophthalmology and human genetics at the Shiley Eye Center at the University of California, San Diego, School of Medicine. "And with the identification of this potential target, we can try to develop treatments for a disease which, for the moment, we can't treat."

The findings were expected to be published online Aug. 28 in the New England Journal of Medicine.

But celebration over isolating TLR3's role in dry age-related macular degeneration (AMD) has been tempered by some potentially troubling implications that the new findings seem to have for a cutting-edge investigational treatment recently unveiled to target the so-called "wet" form of AMD.

The treatment in question, known as "RNA interference," or RNAi, works by "silencing" genes that bring about wet AMD.
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
3. Immune deficiency linked to a type of eye cancer
4. Drop in breast cancer incidence linked to hormone use, not mammograms
5. Clinical depression linked to abnormal emotional brain circuits
6. Air pollution linked to cardiovascular risk indices in healthy young adults
7. High pollution linked to poor lung function growth in children in Mexico City
8. Early Weight Loss in Women Linked to Dementia
9. Vitamin Es lack of heart benefit linked to dosage
10. Sugary Sodas High in Diabetes-Linked Compound
11. RA Drugs Linked to Slight Skin Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Allergy and Infectious Diseases (NIAID), part of the ... clinical trial of CRS3123, an investigational oral antibiotic ... C. difficile ) infection. CRS3123 (previously known as ... difficile growth while sparing normal intestinal bacteria. , ... 30 healthy men and women ages 18 to ...
(Date:7/9/2014)... A retrospective study conducted by researchers at Tufts ... among adults with intellectual and developmental disabilities, the likelihood ... receiving dental care increased. The findings, published in the ... may help improve interventions designed to address the oral ... researchers reviewed the dental records of 107 patients at ...
(Date:7/9/2014)... linking older age with kidney and heart disease have ... among older adults. However, in the first study to ... School of Medicine at the University of Pennsylvania report ... similar life expectancy and cardiovascular health as very healthy ... light of the ever increasing organ transplant waitlists, the ...
(Date:7/9/2014)... 9, 2014 A study published in the scientific ... and Robert Bonin, two researchers at Universit Laval, reveals ... a new method that involves rekindling pain so that ... to novel means to alleviate chronic pain. , The ... and Institut universitaire en sant mentale de Qubec (IUSMQ) ...
(Date:7/9/2014)... Molecular microbiologists from the Keck School of Medicine ... discovered that mice lacking a specific component of ... a potentially fatal complication of infection. The discovery ... help reduce inflammation in human autoimmune and hyper-inflammatory ... diabetes. , The study was published online on ...
Breaking Medicine News(10 mins):Health News:NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection 2Health News:Adults with special needs see gains, challenges with long term oral care 2Health News:Adults with special needs see gains, challenges with long term oral care 3Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2Health News:Discovery of a new means to erase pain 2
... Sept. 26 Tim Dupler, the former,President of Ronco ... LLC to design and implement a new international direct ... Board: NNTN).,During his tenure as President of Ronco, the ... in less than one year. Fred Zeidman, Chairman ...
... ... Channel Partner, ... G-Trainer anti-gravity treadmill, today announced advisor,relationships with world-renowned industry experts ... Alter-G,s anti-gravity treadmill, the G-Trainer, enables users to,reduce their effective ...
... SANTA BARBARA, Calif., Sept. 25 September,26th marks ... is a,lethal, extremely painful cancer in which membrane ... resulting tumor thickens and hardens,crushing the lungs and ... even breathing is excruciating, or invading the heart, ...
... Fattah votes in favor of health insurance for low-income ... ... Congressman Chaka,Fattah (D-PA) joined with a bi-partisan coalition of his colleagues today,and ... "For years I have been a supporter of both The Children,s ...
... Despite strong evidence that cardiac rehabilitation reduces disability and ... rehabilitation services after a heart attack or coronary bypass ... of the American Heart Association. , We need to ... because it is used very little by patients who ...
... Sept. 25 Gentiva Health,Services, Inc. (Nasdaq: ... health and related services, today announced that it ... Securities and,Exchange Commission (SEC) for the periodic offering ... securities, preferred stock, common stock and warrants,after the ...
Cached Medicine News:Health News:Former Ronco President Tim Dupler Signs International Direct Sales and Marketing Contract with Natural Nutrition 2Health News:Alter-G Forging New Relationships 2Health News:Alter-G Forging New Relationships 3Health News:Meso Awareness Day, September 26th: 2Health News:Meso Awareness Day, September 26th: 3Health News:Rehabilitation significantly underused after heart attack and bypass surgery 2Health News:Rehabilitation significantly underused after heart attack and bypass surgery 3Health News:Gentiva(R) Health Services Files Universal Shelf Registration Statement 2Health News:Gentiva(R) Health Services Files Universal Shelf Registration Statement 3
(Date:1/15/2014)... Most osteoporosis patients want a choice in the ... sponsored by Mission Pharmacal Company. The survey, conducted by ... support community, revealed that 74 percent of osteoporosis patients ... form other than a pill or a tablet. ...
(Date:1/15/2014)... 2014  Celsion Corporation (the "Company") (NASDAQ: CLSN ... institutional investors to purchase an aggregate of approximately $15 ... registered direct offering, led by a dedicated health care ... agreements with these investors pursuant to which the Company ...
(Date:1/15/2014)... 15, 2014  Manufacturers, suppliers and distributors of innovative ... protect their most important business assets, intellectual property ... Because of the highly-competitive nature of ... of the most litigious industry sectors of cases ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Intellectual Property Insurance for Medical-related Products and Services 2
... the Treatment of Periodontitis -- STOCKHOLM, November 10, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, ...
... Nov. 9, 2010 Kensey Nash Corporation (Nasdaq: ... Inc., a worldwide leader in sports medicine product development ... agreement for the European distribution of Kensey Nash,s unique ... CRD technology consists of a biphasic bioresorbable scaffold intended ...
Cached Medicine Technology:New Study Published: Lactobacillus reuteri Prodentis Effective in the Treatment of Periodontitis 2New Study Published: Lactobacillus reuteri Prodentis Effective in the Treatment of Periodontitis 3New Study Published: Lactobacillus reuteri Prodentis Effective in the Treatment of Periodontitis 4New Study Published: Lactobacillus reuteri Prodentis Effective in the Treatment of Periodontitis 5New Study Published: Lactobacillus reuteri Prodentis Effective in the Treatment of Periodontitis 6New Study Published: Lactobacillus reuteri Prodentis Effective in the Treatment of Periodontitis 7New Study Published: Lactobacillus reuteri Prodentis Effective in the Treatment of Periodontitis 8Kensey Nash and Arthrex Announce European Distribution Agreement for the Cartilage Repair Device 2Kensey Nash and Arthrex Announce European Distribution Agreement for the Cartilage Repair Device 3
... ExTOL systems feature your choice of ... electrocardiographs, an easy-to-operate monitor and the ... exercise stress testing systems also feature ... point, pre-programmed or custom protocols, and ...
... w/ Remote/Controller. Includes Full Range ... Children. Multiple 20/20 slides. Polarized ... allows you to customize your slide choices. ... with Long Life. Variety of mounting options. ...
... Ultimate in Stability. ... stabilizer features superior arm ... in the clamp/turret mechanism. ... features the ultimate flexibility ...
... leader in beating heart bypass, comes the ... NS device is the first leap in ... of surgical revascularization.,The Starfish NS Heart Positioner ... Small Thoracotomy (MVST) procedure without CPB and ...
Medicine Products: