Navigation Links
Gene Explains How High-Fructose Diets Lead to Insulin Resistance
Date:3/6/2009

Corn syrup more easily metabolizes to fat in liver, which may trigger disease, study says

FRIDAY, March 6 (HealthDay News) -- A gene called PGC-1b appears to play a role in insulin resistance that can be caused by consuming large amounts of high-fructose corn syrup, a sweetener found in most sodas and many processed foods.

Researchers found that mice fed a high-fructose diet were protected from insulin resistance when PGC-1b activity was blocked in the rodents' liver and fat tissue. The findings were published in the March issue of Cell Metabolism.

"There has been a remarkable increase in consumption of high-fructose corn syrup," Gerald Shulman, of the Yale School of Medicine, said in a journal news release. "Fructose is much more readily metabolized to fat in the liver than glucose is, and, in the process, can lead to nonalcoholic fatty liver disease (NAFLD)," which, in turn, leads to hepatic insulin resistance and type 2 diabetes.

High-fructose corn syrup -- a mixture of the simple sugars fructose and glucose -- came into use in the 1970s. By 2005, the average American consumed about 60 pounds of high-fructose corn syrup a year.

The study authors said their findings indicate that PGC-1b plays an important role in the development of fructose-induced insulin resistance. The gene may offer a target for new drugs to treat insulin resistance, NAFLD and hypertriglyceridemia, they concluded.

In an accompanying commentary, two experts said the study shows that PGC-1b is "a missing link between fructose intake and metabolic disorders."

"The findings ... support the emerging role of gene/environment interaction in modulating the metabolic phenotype and disease pathogenesis. Thus, perturbations of the same regulatory motif may produce vastly different metabolic responses, depending on the specific combinations of dietary nutrients," wrote Carlos Hernandez and Jiandie Lin of the Universi
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New Resource Explains What Seniors Can Do if Medicare Denies Coverage of Their Medicines
2. Fact Sheet Explains Cleaners, Disinfectants
3. Bestselling Author Dr. Timothy Brantley Explains the Connection of Food and Mood
4. Fat Grafting Provides Permanent, Natural Looking Results - Dr. Michael Law Explains Fat Injections as a New Trend in Facial Plastic Surgery
5. Study Explains How Cranberries Prevent Urinary Infections
6. Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs
7. Pioneering Hair Transplant Doctor Explains Procedure on Oprah Winfrey Show
8. Senator Obama Explains His Health Care Plan to SpineUniverse.com
9. Research Explains Benefit of Mini Heart Attack
10. AcaiBerryMD.com Explains the Real Facts About the Acai Berry Fruit
11. Smoking behavior partially explains socioeconomic inequities in lung cancer incidence
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Explains How High-Fructose Diets Lead to Insulin Resistance
(Date:7/30/2014)... Hayward, CA (PRWEB) July 30, 2014 ... and accessories at the lowest prices on the internet ... Lightning Cables in two lengths and two colors. These ... performance standards. , The high quality SF Cable ... 8-pin connector with digital signal delivering faster charging and ...
(Date:7/30/2014)... The family of a Vermont man ... Xarelto lawsuit ( http://www.xareltolawsuitcenter.com/ ) alleging his death ... reports. According to the complaint, which was filed in ... July 25th, the decedent had been taking Xarelto for ... bleed that ultimately led to his death on August ...
(Date:7/30/2014)... Visitors to our region recognize how special it ... protection. Bob Kiesendahl, one of the owners of Woodloch ... Conservancy for donations collected through participation in the Green ... fast, as visitors welcome the opportunity to invest in ... The Kiesendahl family has owned Woodloch Resort for multiple ...
(Date:7/30/2014)... Some obese people have a genetic mutation that seems ... when they see food, researchers report. Gaining a ... pleasure and gratification at the sight of high-calorie foods ... overeating, the scientists suggested. More than one-third of ... by a combination of overeating, a lack of physical ...
(Date:7/30/2014)... KY (PRWEB) July 30, 2014 DRE ... pleased to announce the launch of its Medical ... online resource for medical professionals and equipment vendors. , ... shows and conventions in the United States and around ... the calendar, and that number is always growing. , ...
Breaking Medicine News(10 mins):Health News:SF Cable Delivers Certified Lightning Cable in Multiple Sizes and Colors 2Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit Alleges Man’s Death from Uncontrollable Brain Bleeding Was Caused by Xarelto, Bernstein Liebhard LLP Reports 3Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:Gene Mutation May Make Food More Tempting 2Health News:DRE Launches Online Interactive Medical Trade Show Calendar 2
... metabolisms, which may help them generate the energy they need ... in the July Cell Metabolism , a Cell Press ... before detectable tumors form. By the same token, the studies ... metabolism shifts back before established tumors shrink. "This ...
... colorectal cancer risk, according to a new study in ... Gastroenterological Association (AGA) Institute. Folate is a water-soluble B ... that all forms and sources of folate were associated ... PhD, of the American Cancer Society and lead author ...
... By Serena Gordon HealthDay Reporter , TUESDAY, ... age 2 generally aren,t at risk for future behavioral or ... Kids who are speech-delayed, but don,t have any other developmental ... at age 2. But, the study found, those problems don,t ...
... , TUESDAY, July 5 (HealthDay News) -- People with ... increased risk of death, a new study indicates. ... January 2006 and September 2010 -- that looked at ... specified. Anorexics mistakenly believe they are fat and ...
... include Western lung cancer patients, first-line treatment with ... chemotherapy, according to research presented at the 14th ... by the International Association for the Study of ... kinase inhibitor (TKI) that targets the epidermal growth ...
... ingredients for long-term relationship satisfaction, according to an international ... committed relationships, but contrary to stereotypes, tenderness was more ... Also contrary to expectations of the researchers, men ... relationship, while women were more likely to report being ...
Cached Medicine News:Health News:Metabolic shift may offer early cancer clue 2Health News:High folate intake may reduce risk of colorectal cancer 2Health News:Tots Who Are 'Late Talkers' Typically Turn Out Fine: Study 2Health News:Tots Who Are 'Late Talkers' Typically Turn Out Fine: Study 3Health News:Eating Disorders Appear to Raise Risk of Death 2Health News:EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy 2Health News:Couples report gender differences in relationship, sexual satisfaction over time 2Health News:Couples report gender differences in relationship, sexual satisfaction over time 3
(Date:7/30/2014)... 2014  Today the US Surgeon General issued the most ... or sun burns stating they can lead directly to deadly ... Lushniak , says that "skin cancer is a major public ... exposure to indoor and outdoor ultraviolet light is a major ... in Boca Raton, Florida , Marta ...
(Date:7/30/2014)... July 30, 2014  El Camino Hospital, a leader ... is utilizing the Leaf Patient Monitoring system to help ... movement of patients susceptible to bed sores. ... 138-patient study of the system, which showed dramatic improvement ... patients regularly is the one of the most effect ...
(Date:7/30/2014)... Reportlinker.com announces that a new market ... mHealth and Home Monitoring – 6th Edition ... Executive summary mHealth can revolutionize how ... decreased costs and improved sustainability of the healthcare ... in an early stage, but on the brink ...
Breaking Medicine Technology:Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 2El Camino Hospital Utilizes Cutting-Edge Leaf Patient Monitor System to Help Reduce Risk of Pressure Ulcers 3mHealth and Home Monitoring - 6th Edition 2mHealth and Home Monitoring - 6th Edition 3mHealth and Home Monitoring - 6th Edition 4mHealth and Home Monitoring - 6th Edition 5mHealth and Home Monitoring - 6th Edition 6mHealth and Home Monitoring - 6th Edition 7mHealth and Home Monitoring - 6th Edition 8mHealth and Home Monitoring - 6th Edition 9mHealth and Home Monitoring - 6th Edition 10mHealth and Home Monitoring - 6th Edition 11
... N.Y., Jan. 11 Misonix, Inc. (Nasdaq: MSON ... technology, which in Europe is used for the ablation ... has entered into a new, three year, exclusive distribution ... the distribution of the SonaStar(TM) Ultrasonic Surgical Aspirator, the ...
... , WASHINGTON, Jan. 11 The ... star Aaron Boone is featured in January on , Sharing Miracles ... tells the compelling and inspirational stories of real patients. , Sharing Miracles ... sponsored by the Pharmaceutical Research and Manufacturers of America ( ...
Cached Medicine Technology:Misonix Announces New Distribution Agreement for Peru 2Misonix Announces New Distribution Agreement for Peru 3Major League Baseball Star Aaron Boone on 'Sharing Miracles' 2Major League Baseball Star Aaron Boone on 'Sharing Miracles' 3
... The 9115-5.0 transducer ... transducer imaging at the ... (patented) HST technology, this ... quality when higher frequency ...
TOX/See is a 1-step, hand-held, point-of-care device for the qualitative detection of drug or drug metabolites in human urine....
Compact, bench-top analyser with minimal water volume requirements and easy waste management....
Compact benchtop clinical chemistry system...
Medicine Products: