Navigation Links
Gene Distinguishes Early Birds from Night Owls and Helps Predict Time of Death
Date:11/16/2012

veral years ago while Lim was working in the laboratory of BIDMC Chief of Neurology Clifford Saper, MD, PhD. Lim and the other lab members were studying why older people have trouble sleeping and had joined a research project based at Rush University in Chicago involving 1,200 people who signed on as healthy 65-year-olds and would receive annual neurological and psychiatric examinations.

The cohort's original intent was to determine if there were identifiable precursors to the development of Parkinson's disease or Alzheimer's disease. As part of the research the subjects were undergoing various sleep-wake analyses using a wristband called an actigraph, which provides a reliable record of an individual's pattern of activity. Additionally, in order to provide the scientists with information on sleep-wake patterns within a year of death, the participants had agreed to donate their brains after they died.

But the investigation took a new turn when Lim learned that the same group of subjects had also had their DNA genotyped. Teaming up with investigators from Brigham and Women's Hospital (BWH), Lim and his colleagues compared the wake-sleep behavior of these individuals with their genotypes. These findings were later verified in a group of young volunteers.

They soon discovered a single nucleotide near a gene called "Period 1" that varied between two groups that differed in their wake-sleep behavior. At this particular site in the genome, 60 percent of individuals have the nucleotide base termed adenine (A) and 40 percent have the nucleotide base termed guanine (G). Because we have two sets of chromosomes, in any given individual, there's about a 36 percent chance of having two As, a 16 percent chance of having two Gs, and a 48 percent chance of having a mixture of A and G at this site.

"This particular genotype affects the sleep-wake pattern of virtually everyone walking around, and it is a fairly profound effect so that the people w
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Marker distinguishes more-aggressive from less-aggressive forms of chronic leukemia
2. Early Menstruation Tied to Factors That Raise Heart Disease Risk
3. Early 50s may be key time to reach baby boomers with health messages
4. Early Exposure to Stress at Home Affects Girls Brains, Study Says
5. JCI early table of contents for Nov. 12, 2012
6. Predrinking Nearly Doubles Booze Consumption: Study
7. Early treatment sparks striking brain changes in autism
8. Imaging speeds early diagnosis of heart disease, the top killer in the Western world
9. JCI early table of contents for Nov. 1, 2012
10. Meth vaccine shows promising results in early tests
11. Radiation treatment after surgery improves survival for elderly women with early-stage breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... 2015 , ... As if mood swings, cramps and child labor weren’t enough ... leg pain. Northeast Houston Vein Center is offering tips on the treatment options for ... is underdiagnosed and often overlooked. Many women experience the tiredness, achiness, restless legs, cramps ...
(Date:7/1/2015)... ... ... Trevor L. Williams, DMD holds a Bachelor of Science degree in Biomedical Sciences ... in Microbiology. He graduated from the University of Florida College of Dentistry in 2015 ... and the Academy of General Dentistry. Dr. Williams was born in Tampa and is ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... of IBM software products, announced today that it has received trademark protection for ... display and detailed analysis of data from multiple sources providing an environment where ...
(Date:7/1/2015)... ... 2015 , ... A Priority Setting Partnership put in place ... they hope will guide future mesothelioma research. Surviving Mesothelioma has just posted an ... , More than 450 mesothelioma patients, caregivers, and healthcare professionals answer the mesothelioma ...
(Date:7/1/2015)... York (PRWEB) , ... July 01, 2015 , ... Author Francesca Camp wasn’t ... fell into her lap, so too did her support of the practice; a terrible car ... , In her new book, “Do I Need It ? (And What if I ...
Breaking Medicine News(10 mins):Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 2Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 3Health News:Trevor L. Williams, D.M.D. Joins Enlow & Vance Dental Partners in Tampa, Florida 2Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 2Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 3Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 4Health News:New Report Identifies Top 10 Mesothelioma Research Priorities, According to Surviving Mesothelioma 2Health News:Francesca Camp’s New Book Unmasks Plastic Surgery Advice 2
... the battle against malignant brain tumors, dual implantation ... showed promising results in a study led by ... of Cincinnati (UC) and University Hospital. , The ... Journal of Neurosurgery, revealed that patients treated with ...
... Gornick LLP, Bailey Perrin Bailey LLP and Weitz &, ... United, States District Court for the Eastern District of New York ... Co., Inc. and Schering-Plough Corporation., ... the law,firms of Parker Waichman Alonso LLP, Becnel Law Firm, LLC, ...
... Five Such Cases Known Worldwide, NEW HYDE PARK, N.Y., ... physicians at LIJ Medical,Center, 25-year-old Stacey Gayle can now look ... radio. At a news conference today, Ms.,Gayle and her doctors ... robbed her of her health, but of the very important,gift ...
... Jan Marini Skin Research,Inc. (JMSR; http://www.janmarini.com ) today ... Age Intervention Eyelash Conditioner,and Age Intervention Masses of Lashes ... patent infringement lawsuit by Allergan Pharmaceutical as,one reason for ... suspend,these products while we strategically review our options," said ...
... general use, experts caution , , THURSDAY, Jan. 17 (HealthDay News)-- Some ... modifies the body,s immune response. , A study in the Jan. ... no history of heart attacks, as well as those in a ... and of subsequent hospitalizations with such a treatment. , But ...
... a lack of knowledge of health risks posed by ... cell phone technology and use continues to expand and evolve, ... potential health risks associated with long-term exposure to radiofrequency energy. ... women and fetuses -- as well as workers subject to ...
Cached Medicine News:Health News:Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors 2Health News:Former Sufferer of Rare Disease Called Musicogenic Epilepsy Thanks LIJ Medical Team That Ended Her Seizures and Gave Her Back the Gift of Music 2Health News:Jan Marini Skin Research Suspends Sales of Popular Eyelash Products 2Health News:Immune Therapy May Help Some Heart Failure Patients 2Health News:Immune Therapy May Help Some Heart Failure Patients 3Health News:Report Urges More Research Into Cell Phones 2Health News:Report Urges More Research Into Cell Phones 3
(Date:7/1/2015)... July 1, 2015  Unilife Corporation (NASDAQ: UNIS ... of injectable drug delivery systems, announced today that its ... June 30, 2015. This amendment removed a covenant that ... cash receipts from customers during the six months ended ... any of the terms of the debt agreement as ...
(Date:7/1/2015)... July 1, 2015 Qiming Venture Partners, today ... Managing Partner effective immediately. William has been ... and participated in many Qiming healthcare deals, and assisted ... Chinese market. Qiming, s success in healthcare is not ... distinguished himself with his outstanding advocacy and service mentality ...
(Date:7/1/2015)... 2015 According to a new ... Method (Biochemical (Calcium Phosphate, Lipofection, Dendrimers), Physical (Electroporation, Nucleofection), ... Global Forecast to 2020", published by MarketsandMarkets, the Transfection ... $957.9 Million by 2020 with a CAGR of 7.2% ... market T ables and 33 F ...
Breaking Medicine Technology:Unilife and OrbiMed Amend Debt Financing Agreement 2Unilife and OrbiMed Amend Debt Financing Agreement 3Qiming Announces the Promotion of William Hu to Managing Partner 2Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 2Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 3Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 4
... Pharmaceuticals Inc. (Nasdaq: CPIX ) announced today that it will report first ... 2010 .  A conference call and live Internet webcast will be held on ... to discuss the results. , , ... in the call, please dial 877-303-1298 (for U.S. callers) or 253-237-1032 (for international ...
... Israel , May 3, 2010 , , ... The Company is Developing an Artificial Sphincter (the AOS-C1000) to,Provide Bowel Control and Prevent Clinical Complications for ... Stimatix GI, located in the Misgav Venture Accelerator, ... with a new means of bowel,control. , , , ...
Cached Medicine Technology:Cumberland Pharmaceuticals To Announce First Quarter 2010 Financial Results on May 13, 2010 2Stimatix GI Reports Encouraging Interim Results 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: