Navigation Links
Gene Discovery Sheds Light on Children's Asthma
Date:12/23/2009

asthma were all young, raising the odds that a gene could be detected (average age about 7). "They might have a stronger genetic component if the disease comes up early," Hakonarson explained.

Most of the kids also had moderate-to-severe asthma, not mild asthma, again indicating that their disease might have a strong genetic component. All were taking fairly high doses of inhaled steroids to help control their illness.

The analysis identified two genetic regions linked to asthma. One was the previously identified chromosome 17 locus, but there was also a newly spotted gene linked to asthma, called DENND1B, pinpointed on chromosome 1q31.

To make sure this wasn't a chance finding, the authors replicated the findings in groups of children in both the United States and Europe, including a group of black children.

"DENND1B is expressed most intensely on dendritic cells and on T lymphocytes [both key players in immune function]," Hakonarson explained. "Dendritic cells sit in the airway and take up any virus, allergen or any foreign culprit which is invading the airway and presents it to the T lymphocyte. Then the T lymphocyte determines what to do with the [invader]."

The T lymphocyte could then decide to ignore the invader, attack it or make a clone so the compound will be recognized again, in which case the person becomes sensitized to this particular compound.

Additional research not reported in this paper has revealed that the DENND1B gene regulates the release of cytokines -- key immune system signaling molecules.

"The level of cytokines probably has something to do with what [T lymphocytes] ultimately do -- ignore it, attack it or make a clone," Hakonarson said.

Now, researchers have "a truckload of work to do" to clarify the picture, he said.

And the whole picture, when ultimately revealed, is likely to be a complex one.

"It's not a surprise to find a confir
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... 2014 Canadian Linen and Uniform Service, ... America, today announced the launch of its new Customer ... with Canadian Linen even easier and more convenient for ... account information online and better communicate with the company. ... ability to:, , Access, download and ...
(Date:8/28/2014)... After more than two years of designing ... to announce the opening of Houston’s Mirror Mirror Beauty ... Mirror Mirror Beauty Boutique offers premium aesthetic services in ... of Richmond and Drexel near Highland Village, Mirror Mirror ... technology in a private, easy to access location. Patients ...
(Date:8/28/2014)... 28, 2014 Clarity PSO , ... re-certified as a federal Patient Safety Organization (PSO) for ... for Healthcare Research and Quality (AHRQ). Clarity PSO will ... and services following the true intentions of the Patient ... ”We are proud and eager to continue our journey ...
(Date:8/28/2014)... 2014 CMMI (Center for Medicare and Medicaid ... care to address patient needs. What does it all mean? ... (with more provider accountability) and reduce the cost of care. ... in the care of a patient get a single payment ... distribute it. If it sounds complicated, that's because it is. ...
(Date:8/28/2014)... 28, 2014 On September 10, the ... Isaacs, the chairperson, president and CEO of Aduro BioTech, ... the Mesothelioma Experts live broadcast. The interview will ... mesothelioma expert nurse practitioner, Mary Hesdorffer, APRN . ... Aduro BioTech’s experimental therapy for malignant pleural mesothelioma, known ...
Breaking Medicine News(10 mins):Health News:Canadian Linen and Uniform Service Launches New Customer Portal 2Health News:Canadian Linen and Uniform Service Launches New Customer Portal 3Health News:Mirror Mirror Beauty Boutique to Welcome Its First Patients 2Health News:Clarity PSO Re-lists as a Patient Safety Organization and Continues to Advance Patient Safety 2Health News:Clarity PSO Re-lists as a Patient Safety Organization and Continues to Advance Patient Safety 3Health News:Med-Certification.com Expects Industry "Hiccups" with New Models for Patient Care and Reimbursement 2Health News:New Clinical Trial: Using the Listeria Virus to Fight Mesothelioma 2Health News:New Clinical Trial: Using the Listeria Virus to Fight Mesothelioma 3
... 6 Align Technology, Inc. (Nasdaq: ALGN ) ... speak at two upcoming financial conferences. Both presentations, as noted ... section of Align Technology,s website at http://investor.aligntech.com . An ... three months. , Conference: Bank ...
... M. D. Anderson Clinical Services Outside of Houston PHOENIX, ... University of Texas M. D. Anderson Cancer Center announced ... here. The initiative joins Arizona,s leading provider of health care ... their families with an unprecedented level of cancer care in ...
... Africa, May 6 The healthcare industry ... vast inequalities in access to care. The ... 85.0% of the population, yet accounts for ... http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO )Public-private partnerships offer an innovative ...
... and wife Ellen honored for generous contribution to New York University ... ... -- Dr. Jan Linhart, D.D.S. and his wife, Ellen Linhart, have ... Education Program at Dr. Linhart’s alma mater. In honor of this ...
... largest hospital ship charity were honored with a humanitarian award at a ... ... May 6, 2009 -- The founders of the world,s largest hospital ship ... London last night. , , , , ,The annual Variety ...
... innovation is L-Tox, for advanced liver support. L-Tox was formulated to ... , ... Anaheim, California (PRWEB) May 6, 2009 - ... a stop product use directive on May 1, 2009. All consumers ...
Cached Medicine News:Health News:Align Technology Executives to Present at Upcoming Financial Conferences 2Health News:Banner Health, M. D. Anderson Announce Cancer Care Facility for Arizona 2Health News:Banner Health, M. D. Anderson Announce Cancer Care Facility for Arizona 3Health News:South Africa not Gaining the Full Benefit of PPPs in the Healthcare Sector, Says Frost & Sullivan 2Health News:South Africa not Gaining the Full Benefit of PPPs in the Healthcare Sector, Says Frost & Sullivan 3Health News:Manhattan Dentist Inducted Into The Sir Harold Acton Society 2Health News:Mercy Ships Founders Receive Humanitarian of the Year Award From Variety Club 2Health News:Mercy Ships Founders Receive Humanitarian of the Year Award From Variety Club 3Health News:Mercy Ships Founders Receive Humanitarian of the Year Award From Variety Club 4Health News:Max Muscle Sports Nutrition Offers Support for Hydroxycut Recall 2Health News:Max Muscle Sports Nutrition Offers Support for Hydroxycut Recall 3
(Date:8/28/2014)... SALT LAKE CITY , Aug. 28, 2014 /PRNewswire-iReach/ ... in 2000 by service academy graduates, has published a ... its concentrated, three-day Leadership Excellence Course . In ... the  Leadership Excellence Course to Albuquerque , ... Tucson . Photo - http://photos.prnewswire.com/prnh/20140828/140814 ...
(Date:8/28/2014)... 28, 2014 The new ... Market (products, applications, techniques, end users and Geography) ... Forecast, 2013 - 2020," indicates that the global ... 2020 registering a CAGR of 9.8% from 2014 ... and cost effectiveness over alternative diagnostic techniques are ...
(Date:8/28/2014)... Aug. 28, 2014   Venaxis, Inc.  (Nasdaq:  APPY), ... obtaining FDA clearance for and commercializing its CE Marked ... aiding in identifying children, adolescent, and young adult patients ... for appendicitis, today announced it will present at three ... Annual Global Investment Conference being held in ...
Breaking Medicine Technology:Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 2Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 3Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 4Academy Leaders Publishes Case Study on Work with Global Pharmaceutical Company 5DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 2DNA Diagnostics Market is Expected to Reach $19 Billion by 2020 - Allied Market Research 3Venaxis to Present at September Investor Conferences 2Venaxis to Present at September Investor Conferences 3
... 2010 Kensey Nash Corporation (Nasdaq: KNSY ... in November.   Michael Celano, Kensey Nash,s ... the Oppenheimer 21st Annual Healthcare Conference at the Waldorf ... p.m. (ET).  To hear the live webcast of the ...
... (Nasdaq: SLTM ), a global leader in the ... ended September 30, 2010. Revenue for the third quarter was ... as compared to the third quarter 2009 revenue of $17.8 ... by a year-over-year 40% increase in sales of treatment tips ...
Cached Medicine Technology:Solta Medical Reports Third Quarter 2010 Results 2Solta Medical Reports Third Quarter 2010 Results 3Solta Medical Reports Third Quarter 2010 Results 4Solta Medical Reports Third Quarter 2010 Results 5Solta Medical Reports Third Quarter 2010 Results 6Solta Medical Reports Third Quarter 2010 Results 7Solta Medical Reports Third Quarter 2010 Results 8
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: