Navigation Links
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
Date:5/8/2013

study addresses that," said lead researcher Dr. Brendan Lee, a professor of molecular and human genetics at Baylor College of Medicine in Houston.

Specifically, Lee's team found two mutations in the WNT1 gene -- one that caused early onset osteoporosis in the Swedish family, and one that caused a more severe form of osteogenesis imperfecta in the Asian family.

The study is one of four in the past two months alone that have identified various WNT1 mutations in families affected by osteogenesis imperfecta. "It's a hot topic right now," said Glorieux, who worked on one of those studies.

Together, the studies "underscore the importance of this protein in controlling bone formation," Lee said.

Both Lee and Glorieux said studying severe forms of brittle bone disease also gives insight into the common form of osteoporosis that affects many older adults.

In the United States, about 16 percent of women older than 50 have full-blown osteoporosis of the hip or lower spine, as do 4 percent of men, according to the U.S. Centers for Disease Control and Prevention. Many more -- including 61 percent of women -- have lower-than-normal bone mass in those areas.

The hope is to eventually develop new therapies for not only osteogenesis imperfecta, but also osteoporosis, Lee said. Knowing the specific WNT proteins involved in bone formation and maintenance gives researchers targets for new drug development, he explained.

Right now, the most common medications for osteoporosis are bisphosphonates, including brands such as Fosamax, Actonel and Boniva. Those drugs slow bone breakdown; unfortunately, they also put the brakes on bone formation, Lee said.

So researchers are trying to develop medications that would help build bone.

"If we can understand the mechanisms key to developing and maintaining bone mass, that opens potential therapeutic avenues," Glorieux said.

The Swedish family in this study had 10 members affected by a rare
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Smell and taste experts to discuss new discoveries
2. LSUHSC research discoveries shed light on common STI
3. New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
4. $50 million to speed discoveries for patients
5. Register now! San Diego meeting will showcase latest aging discoveries
6. Expanding database enables discoveries in emerging field of metabolomics
7. Barrow researchers use magic for discoveries
8. Parents who suck on their infants pacifiers may protect their children against developing allergy
9. Veteransmovinghelp.com Launches Major Offensive in War Against Unemployment
10. Living Long May Protect Against Early Alzheimers, Study Finds
11. Penn study shows national movement against non-medically indicated deliveries prior to 39 weeks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
(Date:7/28/2015)... Minn. (PRWEB) , ... July 28, 2015 , ... ... company Kinetic Data announced that Schneider Electric has completed its upgrade and ... is a global organization with more than 170,000 employees in 134 countries supplying ...
(Date:7/28/2015)... , ... July 28, 2015 , ... ... targeted biologics and biologic-device combination products for the treatment of bone disorders and ... U.S. Patent No. 9,062,300 entitled "Fusion Proteins of Collagen Binding-Domain and Parathyroid Hormone". ...
(Date:7/28/2015)... NC (PRWEB) , ... July 28, 2015 , ... ... cancers are more common in shipbreaking workers than they are in the general ... Click here to read it now. , Researchers at Taiwan’s National Health ...
(Date:7/28/2015)... ... July 28, 2015 , ... Women fear developing Alzheimer's disease more than ... heart attack, and stroke are treatable, but there is little an individual can do ... take part in a clinical trial, reports the July 2015 Harvard Women's Health ...
(Date:7/28/2015)... CA (PRWEB) , ... July 28, 2015 , ... Every ... professionals or to use extreme caution when lighting fireworks in their own neighborhoods. Unfortunately, ... and discussed in a July 3, 2015 USA Today article " Eye Injuries Caused ...
Breaking Medicine News(10 mins):Health News:Schneider Electric Amps Up Its Use of Kinetic Data’s Enterprise Request Management Software 2Health News:Schneider Electric Amps Up Its Use of Kinetic Data’s Enterprise Request Management Software 3Health News:Schneider Electric Amps Up Its Use of Kinetic Data’s Enterprise Request Management Software 4Health News:BiologicsMD, Inc. Announces Additional US Patent Issuance Covering Company’s Pipeline of Targeted Therapies 2Health News:New Findings Suggest Mesothelioma is Not the Only Cancer Threat for Shipbreakers, According to Surviving Mesothelioma 2Health News:Fight Alzheimer's By Taking Part in a Clinical Trial, From the July 2015 Harvard Women's Health Watch 2Health News:Fight Alzheimer's By Taking Part in a Clinical Trial, From the July 2015 Harvard Women's Health Watch 3Health News:Carlsbad Ophthalmologist Discusses Doubling of Fireworks Eye Injuries in Three Year Span 2Health News:Carlsbad Ophthalmologist Discusses Doubling of Fireworks Eye Injuries in Three Year Span 3
... second patient with colorectal carcinoma had taken part in ... This is the result, at least for a group ... examined in the current edition of Deutsches rzteblatt ... 195�) by Konrad Schoppmeyer and his colleagues from Leipzig ...
... so far not been proven that long-acting insulin analogues (LAIAs) ... of patients with type 2 diabetes. Even though the results ... two LAIAs assessed (insulin glargine), the potential long-term benefits and ... investigated. This is the conclusion of a report by the ...
... are looking for ways to live better for less. PUR has teamed ... Rogers to offer guidance on how to incorporate simple, budget-friendly changes into ... Turn the thermostat back. Save as much ... the thermostat back 10-15% for 8 hours.(i) , ...
... already achieving positive results following their successful implementation ... CentraState and Pinnacle health systems will demonstrate ... improve nursing practice as part of the Siemens ... ) experience at the Healthcare Information ...
... US veterans shows key differences in neural activity ... might use brain scans to diagnose post-traumatic stress disorder ... American soldiers who,d recently served in Iraq or Afghanistan. ... of combat exposure. They were divided into two groups, ...
... MGT Capital Investments, Inc. (NYSE AMEX: ... for the year ended December 31, 2008 and provided ... December 31, 2008 MGT Capital Investments, Inc. reported total ... ended December 31, 2007. Total operating expenses for the ...
Cached Medicine News:Health News:Long-acting insulin analogues in type 2 diabetes: advantage over human insulin not proven 2Health News:Long-acting insulin analogues in type 2 diabetes: advantage over human insulin not proven 3Health News:Long-acting insulin analogues in type 2 diabetes: advantage over human insulin not proven 4Health News:Photos: Tips for Living a Healthy Lifestyle on a Budget 2Health News:Photos: Tips for Living a Healthy Lifestyle on a Budget 3Health News:Photos: Tips for Living a Healthy Lifestyle on a Budget 4Health News:Designing the Care-Planning Process to Guide Evidence-Based Practice 2Health News:Designing the Care-Planning Process to Guide Evidence-Based Practice 3Health News:Designing the Care-Planning Process to Guide Evidence-Based Practice 4Health News:Brain Scans Might Help Spot PTSD 2Health News:MGT Capital Investments, Inc. Reports Fiscal 2008 Financial Results and Provides an Update on Recent Developments 2Health News:MGT Capital Investments, Inc. Reports Fiscal 2008 Financial Results and Provides an Update on Recent Developments 3
(Date:7/28/2015)... WALTHAM, Mass. , July 28, 2015  Alere ... rapid diagnostics, today announced that it will release its ... 2015. The Company will host a conference call beginning ... to discuss these results and provide business updates. ... on the Investor Relations section of Alere,s website, or ...
(Date:7/28/2015)... Calif. , July 28, 2015  Cepheid ... Omni, a flexible and portable clinical molecular diagnostic ... Point of Care market.  At just 9 inches ... Omni will run the same high quality PCR-based ... Systems, enabling highly accurate clinical molecular diagnostic tests ...
(Date:7/28/2015)... July 28, 2015 Isis Pharmaceuticals, Inc. (NASDAQ: ... a live webcast on Tuesday, August 4 at 11:30 ... financial results and report on pipeline and business progress.  ... call by dialing 877-443-5662 or access the webcast at ... for a limited time at the same address. ...
Breaking Medicine Technology:Alere to Report Second Quarter 2015 Financial Results on August 4, 2015 2World's First "Go-Anywhere" Molecular Diagnostic System Unveiled at AACC 2World's First "Go-Anywhere" Molecular Diagnostic System Unveiled at AACC 3World's First "Go-Anywhere" Molecular Diagnostic System Unveiled at AACC 4Webcast Alert: Isis Pharmaceuticals' Second Quarter 2015 Financial Results Conference Call 2Webcast Alert: Isis Pharmaceuticals' Second Quarter 2015 Financial Results Conference Call 3
... Adeona Pharmaceuticals, Inc. (AMEX: AEN ), a ... reported its second quarter 2011 financial results for the period ended ... the second quarter. Updates since the beginning of ... Multiple Sclerosis (MS) ...
... Aug. 15, 2011 /PRNewswire-Asia-FirstCall/ -- Lotus Pharmaceuticals, Inc. (OTCBB: ... and seller of medicine and drugs in the People,s ... for the quarter ended June 30, 2011. Summary financial ... Quarter Financial Highlights Revenues for ...
Cached Medicine Technology:Adeona Reports Second Quarter 2011 Financial Results 2Adeona Reports Second Quarter 2011 Financial Results 3Adeona Reports Second Quarter 2011 Financial Results 4Adeona Reports Second Quarter 2011 Financial Results 5Adeona Reports Second Quarter 2011 Financial Results 6Adeona Reports Second Quarter 2011 Financial Results 7Adeona Reports Second Quarter 2011 Financial Results 8Adeona Reports Second Quarter 2011 Financial Results 9Lotus Pharmaceuticals Announces Second Quarter Fiscal 2011 Financial Results 2Lotus Pharmaceuticals Announces Second Quarter Fiscal 2011 Financial Results 3Lotus Pharmaceuticals Announces Second Quarter Fiscal 2011 Financial Results 4Lotus Pharmaceuticals Announces Second Quarter Fiscal 2011 Financial Results 5Lotus Pharmaceuticals Announces Second Quarter Fiscal 2011 Financial Results 6Lotus Pharmaceuticals Announces Second Quarter Fiscal 2011 Financial Results 7
Enzyme Immunoassay of von Willebrand Factor Antigenby ELISA Method, 96 tests....
Enzyme Immunoassay of Tissue Plasminogen Activator Antigen by ELISA Method, 96 tests....
Calibration plasmas for Assays of Low Molecular Weight Heparins (LMWH)using the Anti-Xa method on STA© Analyzers....
Control Plasma for Assays of Unfractionated Heparins (UH) using Anti-Xa Methodon STA© Analyzers....
Medicine Products: