Navigation Links
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
Date:5/8/2013

By Amy Norton
HealthDay Reporter

WEDNESDAY, May 8 (HealthDay News) -- Mutations in a gene involved in bone development appear to cause certain severe forms of bone loss, a finding that could lead to new therapies for the common bone-thinning disorder osteoporosis, researchers report.

The mutations were found in a Swedish family with 10 members affected by a severe, early onset form of osteoporosis, as well as a Hmong family from Laos in which two sisters suffered from osteogenesis imperfecta.

Osteogenesis imperfecta, which is also known as brittle bone disease, affects six to seven out of every 100,000 people worldwide. The disease causes the bones to break easily, often from little or no trauma. There are four main forms, the most severe of which is fatal before or soon after birth.

The most common -- and mildest -- form is Type 1, in which most of a child's bone fractures happen before puberty. Some other problems, such as weak muscles and brittle teeth, are also possible.

Researchers have long known that about 90 percent of osteogenesis imperfecta cases are caused by a single mutation in one of two genes involved in making collagen, a fibrous protein in bone, skin and connective tissue.

It is only in the past decade, though, that the mystery behind the other 10 percent has become clearer, said Dr. Francis Glorieux, chairman of the Osteogenesis Imperfecta Foundation's medical advisory council.

The latest findings, published in the May 9 issue of the New England Journal of Medicine, underscore the role of a gene family known as WNT, said Glorieux, who was not involved in the research.

WNT genes make proteins called ligands, which means they latch onto receptors on the surface of body cells. Scientists have known that WNT is important in bone development and the upkeep of bone mass.

"But we haven't known which protein is key, which WNT ligand is actually doing the work. This
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Smell and taste experts to discuss new discoveries
2. LSUHSC research discoveries shed light on common STI
3. New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
4. $50 million to speed discoveries for patients
5. Register now! San Diego meeting will showcase latest aging discoveries
6. Expanding database enables discoveries in emerging field of metabolomics
7. Barrow researchers use magic for discoveries
8. Parents who suck on their infants pacifiers may protect their children against developing allergy
9. Veteransmovinghelp.com Launches Major Offensive in War Against Unemployment
10. Living Long May Protect Against Early Alzheimers, Study Finds
11. Penn study shows national movement against non-medically indicated deliveries prior to 39 weeks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
(Date:10/30/2014)... (PRWEB) October 30, 2014 Graphics, coding, ... are synonymous with the craft of web design and ... website. Yet a simpler solution to create a website ... pictures, videos, contact information, customer reviews and Facebook posts ... "It is the next evolution of how a ...
(Date:10/30/2014)... October 30, 2014 Paramount Rx, a ... is increasing efforts to help people save money through ... to increase for prescription drugs in the new health ... and resources to bridge the relationship between consumers, businesses ... the biggest challenges people face today with medical costs ...
(Date:10/30/2014)... Toronto, Canada (PRWEB) October 30, 2014 ... the area’s leading provider of non-medical, in-home senior care, ... activity to increased brain health. , The study, performed ... the ages of 60 and 78 over a week-long ... as opposed to daily physical activity. By examining the ...
(Date:10/30/2014)... REV'D Provision Co. announced today that ... a unique service called, The Feed . The ... everyday athlete. The Feed has taken the nutritional knowledge ... system to pass that information on to the everyday ... available on The Feed!” says REV’D® marketing manager Matt ...
(Date:10/30/2014)... it comes to heart disease, a new study finds women ... have symptoms that spell trouble. "The main danger is ... severe or advanced stage of heart disease, there are simply ... Scholar and research fellow at the Harvard School of Public ... Stroke Foundation of Canada. In the study, researchers talked ...
Breaking Medicine News(10 mins):Health News:Facebook Websites In Thirty-Seconds 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 2Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 3Health News:Nutrition Experts at TheFeed.com Get REV'D 2Health News:Nutrition Experts at TheFeed.com Get REV'D 3Health News:Women Often Ignore Signs of Heart Trouble 2
... operation, a team of doctors here sucessfully removed a 'minute ... 11-month-old (RPT 11-month-old) boy. // ,Dr Palaniappan of ... perform the operation recently, told PTI here that Muniraj was ... food for the last one-and-a-half months., ,After trying different ...
... it would raise 16 million dollar through the issue Foreign ... company would allot 16,000 FCCBs of 1,000 dollar each to ... Singapore Stock Exchange, Ankur Drugs informed the Bombay Stock Exchange., ... 14,000 FCCBs while 1,000 FCCBs would be given to DKR ...
... transmission of the deadly bird flu virus among members of ... has sought to assure the public that potentially dangerous mutation ... maintained that human contagion cannot be ruled out in the ... far there has been no evidence that efficient human-to-human transmission ...
... outbreak of bird flu at a poultry farm in Kakara ... ,Timothy Obi, leader of the Avian Influenza task force ... reporters that the institute claimed to have diagnosed samples of ... infected with the deadly H5N1 virus. ,An official ...
... has been announced states that all the state schools are to ... This is part of their drive against obesity. , ... milk to pupils aged 3 to 18. The ruling also applies ... and to cartons sold in vending machines. ,This ban ...
... that is available in the British Medical Journal has suggested that ... the heart // , but these benefits seem to favor men ... on 50,000 Danish men and women in the age bracket of ... study did show that women who took alcohol at least one ...
Cached Medicine News:Health News:Fresh Outbreak Of Bird Flu In Nigeria 2Health News:All State Run Schools Are To Ban Whole Milk To Children 2Health News:All State Run Schools Are To Ban Whole Milk To Children 3
(Date:10/30/2014)... nebulizer is a medical device used for ... fibrosis) that converts liquid medication into mist or aerosol. ... of a patient when inhaled through the mouth or ... by various devices powered by electric current and rechargeable ... and cystic fibrosis and growing number of geriatric population ...
(Date:10/30/2014)... LOS ANGELES , Oct. 29, 2014 /PRNewswire/ ... pharmaceutical company devoted to bringing new products to ... 2015. ViaDerma has developed an innovative, ... for rapid mass transfer of pharmaceutical active ingredients ... to provide immediate localized therapy. The transdermal delivery ...
(Date:10/30/2014)... The global market for human vaccines ... of new vaccines. These new products and other ... The Kalorama information report examines the global market ... vaccines for diseases that are already vaccine-preventable. ... communities from diseases spread by person-to-person transmission. The ...
Breaking Medicine Technology:Nebulizers Market (Pneumatic Nebulizers, Ultrasonic Nebulizers and Mesh Nebulizers) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Nebulizers Market (Pneumatic Nebulizers, Ultrasonic Nebulizers and Mesh Nebulizers) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3Vaccines 2014: World Market Analysis, Key Players, Trends, Pediatric and Adult Segments 2Vaccines 2014: World Market Analysis, Key Players, Trends, Pediatric and Adult Segments 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: