Navigation Links
Gene Discoveries Could Shed New Light on Schizophrenia
Date:7/22/2014

TUESDAY, July 22, 2014 (HealthDay News) -- One of the largest studies ever conducted into the genetic origins of a psychiatric disorder has uncovered 83 new sites on chromosomes that harbor inherited genes tied to schizophrenia.

The findings, made by an international team of researchers, now bring the total number of common gene variants linked to the disorder to 108.

Although these schizophrenia-associated genes aren't specific enough to be used as a test to predict who will or will not develop the illness, researchers say they might someday be used as a screening tool for high-risk people who may benefit from preventative treatments.

Right now, the total group of schizophrenia-linked genes "only explains only about 3.5 percent of the risk for schizophrenia," Dr. Thomas Insel, director of the U.S. National Institute of Mental Health, said in an agency news release. However, "even based on these early predictors, people who score in the top 10 percent of risk may be up to 20-fold more prone to developing schizophrenia."

Prior research had only identified about 30 common gene variants linked to schizophrenia. In looking for more clues to the molecular basis of the disorder, an international team of more than 500 scientists at more than 80 research institutions in 25 countries re-examined all available schizophrenia gene samples from people with schizophrenia.

The combined data involved more than 37,000 people with schizophrenia and 113,000 people without the disorder.

The analysis looked at people's complete genomes -- the "map" of DNA that makes up a human. Out of a pool of roughly 9.5 million gene variants, the study authors found 108 sites on various chromosomes that appear to be linked to schizophrenia.

The newly discovered sites are grouped around pathways tied to certain processes associated with the disorder. These include communication between brain cells, as well as pathways involving learning, memory and immune function. One site was even focused on a specific target for schizophrenia medication, the study revealed.

One association was confirmed with a variation in a gene that codes for a receptor for dopamine -- a brain chemical messenger that is a known target for drugs used to treat schizophrenia.

The researchers believe that even more genetic clues to schizophrenia could be uncovered in studies with even larger numbers of patients.

"These results underscore that genetic programming affects the brain in tiny, incremental ways that can increase the risk for developing schizophrenia," Thomas Lehner, chief of NIMH's Genomics Research Branch, said in the news release. "They also validate the strategy of examining both common and rare [gene] variation to understand this complex disorder."

The study was published online July 22 in Nature.

More information

The National Alliance on Mental Illness has more about schizophrenia.

SOURCE: U.S. National Institute of Mental Health, news release, July 21, 2014

--


'/>"/>
Copyright©2014 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Barrow researchers use magic for discoveries
2. Expanding database enables discoveries in emerging field of metabolomics
3. Register now! San Diego meeting will showcase latest aging discoveries
4. $50 million to speed discoveries for patients
5. New discoveries linking gut bacteria with cholesterol metabolism give hope for the future
6. LSUHSC research discoveries shed light on common STI
7. Smell and taste experts to discuss new discoveries
8. Gene Discoveries Give Hope Against Brittle Bone Disease
9. Yves Pichon’s New Book Presents Latest Neurophysiological Discoveries
10. Alzheimer’s Disease: Landmark Gene Discoveries Open Up New Therapeutic Opportunities
11. Ohio State and Microlin Bio Inc. to bring transformational cancer discoveries to patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Discoveries Could Shed New Light on Schizophrenia
(Date:5/27/2016)... ... May 27, 2016 , ... In response to meager public ... unaware of the plight of aphasia. In collaboration with the American Aphasia Association, ... , The link between stroke and aphasia is relatively unknown, but through collaboration ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed ... by inspiring human interest stories, courtesy of leaders in the nursing and health ... the industry, from leading advocates and associations—namely Jones & Bartlett Learning. , Jones ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... her award on May 18 at the university’s Student Leadership Awards ceremony. , ...
(Date:5/26/2016)... ... 26, 2016 , ... Despite last week’s media reports hinting at a June ... wait until March 2017 for an interest rate increase, according to Rajeev Dhawan of ... , “The Federal Open Market Committee (FOMC) dot charts are of interest to the ...
(Date:5/26/2016)... ... , ... W.S. Badger Co. Inc ., the maker of certified organic ... Works Award for its use of effective workplace strategies to increase business and employee ... by the Families and Work Institute (FWI) and the Society for Human Resource Management ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... PUNE, India , May 27, 2016 ... in the instances of hypertension is driving ambulatory blood ... muscles lose their elasticity and their ability to respond ... blood pressure. This condition can lead to various cardiovascular ... and peripheral vascular disease. These diseases are growing in ...
(Date:5/27/2016)... -- The healthcare sector is large and ... falling under its umbrella.  A rather overlooked sector are ... about, these healthcare companies are still trying to prove ... by far the largest consumer of the healthcare market ... Nutranomics Inc. (OTC: NNRX), KollagenX Corp. (OTCQB: KGNX), Bioelectronics ...
(Date:5/26/2016)... , May 26, 2016   ... software and analytics, network solutions and technology-enabled ... announced it entered into a strategic channel ... of outpatient software solutions and revenue cycle ... specialty hospitals and rehabilitation clinics to optimize ...
Breaking Medicine Technology: