Navigation Links
Gene Could Play Role in 'Intersex' Conditions
Date:12/2/2010

By Alan Mozes
HealthDay Reporter

THURSDAY, Dec. 2 (HealthDay News) -- An international team of scientists have pinpointed a gene mutation that they believe could be key to so-called "intersex" conditions, in which biologically male or female children develop or display some of the physical characteristics of the opposite sex.

"We have discovered a new molecular switch that seems to modulate the pathways between male and female development," study author Dr. Harry Ostrer, director of the Human Genetics Program at NYU Langone Medical Center, said in a news release.

Ostrer and colleagues from England, Australia and France report their finding in the Dec. 2 issue of the American Journal of Human Genetics.

This is not the first time a gene abnormality has been cited for its role in conditions linked to sex determination, the authors noted. Among a number of prior discoveries, about 20 years back researchers honed in on a male gene called SRY and linked related mutations to such anomalies.

However, the current focus on various mutations of the so-called MAP3K1 gene revealed that this particular gene may, in fact, act as a controlling on/off switch with respect to SRY activity, either prompting or discouraging an intersex condition.

"MAP3K1 may hold the key to understanding how these various genes are connected," Ostrer noted.

The authors point out that about one in 1,000 people are affected by intersex conditions, which counters the notion that gender is determined by simple X/Y chromosome patterns.

Normally, male fetuses are distinguished by a pairing of an X chromosome alongside a Y chromosome, while female fetuses are determined by a pairing of two X chromosomes.

Problems occur, however, when a male baby born with an X/Y pairing nonetheless develops some physical attributes of a female child, such as a urethral opening on the underside of the penis or abnormalities such as an underdeveloped or extremely small penis.

Such Y-chromosome intersex children may develop as females but without the ability to menstruate, with partially developed ovaries, an overdeveloped clitoris, excess hair, or ovarian tumors, the research team noted. Infertility can also result.

Ostrer and his associates spent nine years exploring the potential impact of MAP3K1 on intersex conditions by tracking sex determination problems present among two families, one French, the other in New Zealand.

More information

For more on intersex, visit the Intersex Society of North America.

-- Alan Mozes

SOURCE: American Journal of Human Genetics, Dec. 2, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Disease Prevention Could Save U.S. Billions of Dollars Annually
2. True whole-body field view using PET/CT could allow doctors to more accurately manage cancer patients
3. Moderate Drinking Could Lower Death Risk for Kidney Transplant Patients
4. E. Coli Could Have Long Term Effect on Heart
5. Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
6. Low-allergenic wines could stifle sniffles and sneezes in millions of wine drinkers
7. Enzyme action could be target for diabetes, heart disease treatments
8. Detroits urban farms could provide a majority of produce for local residents
9. Reducing salt in teen diet could have big impact on future health
10. Few Make Lifestyle Changes that Could Keep Their Heart Healthy
11. Setting National Hospital Standards Could Boost Cardiac Care
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Could Play Role in 'Intersex' Conditions 
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: