Navigation Links
Gene Could Play Role in 'Intersex' Conditions
Date:12/2/2010

By Alan Mozes
HealthDay Reporter

THURSDAY, Dec. 2 (HealthDay News) -- An international team of scientists have pinpointed a gene mutation that they believe could be key to so-called "intersex" conditions, in which biologically male or female children develop or display some of the physical characteristics of the opposite sex.

"We have discovered a new molecular switch that seems to modulate the pathways between male and female development," study author Dr. Harry Ostrer, director of the Human Genetics Program at NYU Langone Medical Center, said in a news release.

Ostrer and colleagues from England, Australia and France report their finding in the Dec. 2 issue of the American Journal of Human Genetics.

This is not the first time a gene abnormality has been cited for its role in conditions linked to sex determination, the authors noted. Among a number of prior discoveries, about 20 years back researchers honed in on a male gene called SRY and linked related mutations to such anomalies.

However, the current focus on various mutations of the so-called MAP3K1 gene revealed that this particular gene may, in fact, act as a controlling on/off switch with respect to SRY activity, either prompting or discouraging an intersex condition.

"MAP3K1 may hold the key to understanding how these various genes are connected," Ostrer noted.

The authors point out that about one in 1,000 people are affected by intersex conditions, which counters the notion that gender is determined by simple X/Y chromosome patterns.

Normally, male fetuses are distinguished by a pairing of an X chromosome alongside a Y chromosome, while female fetuses are determined by a pairing of two X chromosomes.

Problems occur, however, when a male baby born with an X/Y pairing nonetheless develops some physical attributes of a female child, such as a urethral opening on the underside of the penis or abnormalities such as an underdeveloped or extremely small penis.

Such Y-chromosome intersex children may develop as females but without the ability to menstruate, with partially developed ovaries, an overdeveloped clitoris, excess hair, or ovarian tumors, the research team noted. Infertility can also result.

Ostrer and his associates spent nine years exploring the potential impact of MAP3K1 on intersex conditions by tracking sex determination problems present among two families, one French, the other in New Zealand.

More information

For more on intersex, visit the Intersex Society of North America.

-- Alan Mozes

SOURCE: American Journal of Human Genetics, Dec. 2, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Disease Prevention Could Save U.S. Billions of Dollars Annually
2. True whole-body field view using PET/CT could allow doctors to more accurately manage cancer patients
3. Moderate Drinking Could Lower Death Risk for Kidney Transplant Patients
4. E. Coli Could Have Long Term Effect on Heart
5. Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
6. Low-allergenic wines could stifle sniffles and sneezes in millions of wine drinkers
7. Enzyme action could be target for diabetes, heart disease treatments
8. Detroits urban farms could provide a majority of produce for local residents
9. Reducing salt in teen diet could have big impact on future health
10. Few Make Lifestyle Changes that Could Keep Their Heart Healthy
11. Setting National Hospital Standards Could Boost Cardiac Care
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Could Play Role in 'Intersex' Conditions 
(Date:7/24/2017)... ... July 24, 2017 , ... Axiad IDS , a leading provider of ... with WALLIX to expand its solution to help government contractors more quickly ... number of ways to address the authentication requirements within NIST SP800-171, but no ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... fat (adipose) transfer systems announces the issuance of United States Patent Number 9,695,398 ... its adipose filtration technology. The '398 and '324 patents cover methods and ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... solution focused on delivering end-to-end sleep health care at scale, indicates record-breaking ... shows that adherence rates for positive airway pressure (PAP) therapy, the most widely ...
(Date:7/24/2017)... ... July 24, 2017 , ... Committed to eliminating clubfoot as ... 100,000 children in their treatment program. Clubfoot is a pervasive problem in the ... is limited or non-existent. Without intervention, these children are destined to grow up ...
(Date:7/24/2017)... ... 24, 2017 , ... On July 19th, the Chinese Academy ... the awarding ceremony was held successfully in Beijing. The State Health Planning Commission, ... system, and national Chinese medicine experts also attended the event, including more than ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... , July 13, 2017  New York City-based market research ... markets should be aware of.  From new products to new ... detailed in a recently completed study, Potential Pipeline Disruptors ... 1.  Age-Driven Growth - True ... been aware of the impact the growing population and, to ...
(Date:7/12/2017)...  Eli Lilly and Company (NYSE: LLY ) ... resolve pending patent litigation in the U.S. District Court for ... the Cialis ® (tadalafil) unit dose patent. This patent ... part of the agreement, Cialis exclusivity is now expected to ... "The unit dose patent for Cialis is valid and infringed ...
(Date:7/11/2017)... July 11, 2017  Bayer has awarded grants totaling more ... part of its prestigious Bayer Hemophilia Awards Program (BHAP). Four ... Philadelphia and Uniformed Services University of the ... the winners. Grant recipients were announced last night during a ... 2017 Congress, Berlin, Germany . ...
Breaking Medicine Technology: