Navigation Links
Gene Could Play Role in 'Intersex' Conditions
Date:12/2/2010

By Alan Mozes
HealthDay Reporter

THURSDAY, Dec. 2 (HealthDay News) -- An international team of scientists have pinpointed a gene mutation that they believe could be key to so-called "intersex" conditions, in which biologically male or female children develop or display some of the physical characteristics of the opposite sex.

"We have discovered a new molecular switch that seems to modulate the pathways between male and female development," study author Dr. Harry Ostrer, director of the Human Genetics Program at NYU Langone Medical Center, said in a news release.

Ostrer and colleagues from England, Australia and France report their finding in the Dec. 2 issue of the American Journal of Human Genetics.

This is not the first time a gene abnormality has been cited for its role in conditions linked to sex determination, the authors noted. Among a number of prior discoveries, about 20 years back researchers honed in on a male gene called SRY and linked related mutations to such anomalies.

However, the current focus on various mutations of the so-called MAP3K1 gene revealed that this particular gene may, in fact, act as a controlling on/off switch with respect to SRY activity, either prompting or discouraging an intersex condition.

"MAP3K1 may hold the key to understanding how these various genes are connected," Ostrer noted.

The authors point out that about one in 1,000 people are affected by intersex conditions, which counters the notion that gender is determined by simple X/Y chromosome patterns.

Normally, male fetuses are distinguished by a pairing of an X chromosome alongside a Y chromosome, while female fetuses are determined by a pairing of two X chromosomes.

Problems occur, however, when a male baby born with an X/Y pairing nonetheless develops some physical attributes of a female child, such as a urethral opening on the underside of the penis or abnormalities such as an underdeveloped or extremely small penis.

Such Y-chromosome intersex children may develop as females but without the ability to menstruate, with partially developed ovaries, an overdeveloped clitoris, excess hair, or ovarian tumors, the research team noted. Infertility can also result.

Ostrer and his associates spent nine years exploring the potential impact of MAP3K1 on intersex conditions by tracking sex determination problems present among two families, one French, the other in New Zealand.

More information

For more on intersex, visit the Intersex Society of North America.

-- Alan Mozes

SOURCE: American Journal of Human Genetics, Dec. 2, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Disease Prevention Could Save U.S. Billions of Dollars Annually
2. True whole-body field view using PET/CT could allow doctors to more accurately manage cancer patients
3. Moderate Drinking Could Lower Death Risk for Kidney Transplant Patients
4. E. Coli Could Have Long Term Effect on Heart
5. Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
6. Low-allergenic wines could stifle sniffles and sneezes in millions of wine drinkers
7. Enzyme action could be target for diabetes, heart disease treatments
8. Detroits urban farms could provide a majority of produce for local residents
9. Reducing salt in teen diet could have big impact on future health
10. Few Make Lifestyle Changes that Could Keep Their Heart Healthy
11. Setting National Hospital Standards Could Boost Cardiac Care
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Could Play Role in 'Intersex' Conditions 
(Date:6/27/2016)... Lafayette, California (PRWEB) , ... ... ... a pioneer in the patient payment industry today announced its strategic partnership ... and health system workflows. , The two companies’ proven, proprietary technology combine ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
Breaking Medicine Technology: