Navigation Links
Gene Could Play Role in 'Intersex' Conditions

By Alan Mozes
HealthDay Reporter

THURSDAY, Dec. 2 (HealthDay News) -- An international team of scientists have pinpointed a gene mutation that they believe could be key to so-called "intersex" conditions, in which biologically male or female children develop or display some of the physical characteristics of the opposite sex.

"We have discovered a new molecular switch that seems to modulate the pathways between male and female development," study author Dr. Harry Ostrer, director of the Human Genetics Program at NYU Langone Medical Center, said in a news release.

Ostrer and colleagues from England, Australia and France report their finding in the Dec. 2 issue of the American Journal of Human Genetics.

This is not the first time a gene abnormality has been cited for its role in conditions linked to sex determination, the authors noted. Among a number of prior discoveries, about 20 years back researchers honed in on a male gene called SRY and linked related mutations to such anomalies.

However, the current focus on various mutations of the so-called MAP3K1 gene revealed that this particular gene may, in fact, act as a controlling on/off switch with respect to SRY activity, either prompting or discouraging an intersex condition.

"MAP3K1 may hold the key to understanding how these various genes are connected," Ostrer noted.

The authors point out that about one in 1,000 people are affected by intersex conditions, which counters the notion that gender is determined by simple X/Y chromosome patterns.

Normally, male fetuses are distinguished by a pairing of an X chromosome alongside a Y chromosome, while female fetuses are determined by a pairing of two X chromosomes.

Problems occur, however, when a male baby born with an X/Y pairing nonetheless develops some physical attributes of a female child, such as a urethral opening on the underside of the penis or abnormalities such as an underdeveloped or extremely small penis.

Such Y-chromosome intersex children may develop as females but without the ability to menstruate, with partially developed ovaries, an overdeveloped clitoris, excess hair, or ovarian tumors, the research team noted. Infertility can also result.

Ostrer and his associates spent nine years exploring the potential impact of MAP3K1 on intersex conditions by tracking sex determination problems present among two families, one French, the other in New Zealand.

More information

For more on intersex, visit the Intersex Society of North America.

-- Alan Mozes

SOURCE: American Journal of Human Genetics, Dec. 2, 2010, news release.

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Disease Prevention Could Save U.S. Billions of Dollars Annually
2. True whole-body field view using PET/CT could allow doctors to more accurately manage cancer patients
3. Moderate Drinking Could Lower Death Risk for Kidney Transplant Patients
4. E. Coli Could Have Long Term Effect on Heart
5. Cough medicine could help doctors identify how breast cancer patients metabolize tamoxifen
6. Low-allergenic wines could stifle sniffles and sneezes in millions of wine drinkers
7. Enzyme action could be target for diabetes, heart disease treatments
8. Detroits urban farms could provide a majority of produce for local residents
9. Reducing salt in teen diet could have big impact on future health
10. Few Make Lifestyle Changes that Could Keep Their Heart Healthy
11. Setting National Hospital Standards Could Boost Cardiac Care
Post Your Comments:
Related Image:
Gene Could Play Role in 'Intersex' Conditions 
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from reveals that behind the tendency to set low expectations is ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group ... Tournament held on June 20th at the Woodmont Country Club at 1201 Rockville ... an organization dedicated to helping service members that have been wounded in battle and ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... LAS VEGAS , June 26, 2016 ... movement to value-based care operating models within the health ... that enable greater financial efficiency , Deloitte offers ... address the key business issues impacting efficient cost optimization: ... alignment , These services facilitate better outcomes and ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
Breaking Medicine Technology: