Navigation Links
Gene Connections Key to Brain Tumor Growth
Date:7/14/2009

Discovery could help change disease from fatal to chronic, researcher says

TUESDAY, July 14 (HealthDay News) -- Researchers have identified a network of mutated genes and gene processes that, together, contribute to the development of glioblastomas, the deadliest type of brain tumor.

"There is not a single gene that accounts for the development of brain tumors," explained Dr. Markus Bredel, co-author of two related papers in the July 15 issue of the Journal of the American Medication Association. "It's the concert of those genes and the interaction of those genes that ultimately determine the progression of cancer."

Bredel, who is director of the Brain Tumor Institute Research Program at Northwestern University's Feinberg School of Medicine in Chicago, proposed that a combination of therapies targeting specific biological events might improve treatment outcomes for this type of cancer. Outcomes have remained stubbornly the same for about three decades.

"We hope that's the future of therapy -- that we can, over the long term, transfer this into a more chronic disease so patients could hopefully live 10 to 15 years," Bredel said. Development of a cure in that time frame is unlikely, he said.

People with glioblastomas now live an average of 12 to 14 months. U.S. Sen. Edward M. Kennedy (D-Mass.) was diagnosed in May 2008 with a malignant brain tumor.

"The authors have really made sense of these genetic changes and identified some of the pathways that seem to be crucial for glioblastoma development," said Dr. Boris Pasche, co-author of an accompanying editorial in the journal and associate director of the Comprehensive Cancer Center at the University of Alabama at Birmingham. "It's very exciting because it holds promise for identification of the Achilles' heel of this disease. If you can target several pathways that are implicated in a given disease, you can effectively change the course of the disease."

According to Bredel, up to 50 percent of the 30,000 to 40,000 genes in the human genome may be altered in glioblastoma.

The key is discovering which changes are actually important.

"Many of those changes will be just passengers or bystanders," Bredel said. "We tried to count up and prioritize the genes that are potentially the most important in glioblastoma disease and as a means to develop future therapy."

Starting with a genome-wide approach, using tissue from 501 people with this type of tumor, the researchers whittled their way down to 31 genes that appear to be the captains or godfathers of the complex genetic changes leading to glioblastoma.

These 31 genes were altered in up to 75 percent of glioblastomas, forming a landscape common to about three-quarters of all cases of glioblastoma, the study found.

And within those 31 genes, a subset of seven genes allowed the researchers to group the disease into low, intermediate and high risk in terms of outcome, a tool that may be useful for prognosis, they said.

Not only the genes were important, but the relationships between them were also critical, the researchers found.

In their second study, the researchers delved deeper into the mechanisms driving two of the 31 genes -- one so-called hub of genes and one gene that interacted with that hub, meaning those that have a high level of connectivity with the other genes.

The hub gene is the EGFR (epidermal growth factor receptor) oncogene on chromosome 7, according to the study. It is amplified in about 45 percent of glioblastoma cases, Bredel said. Oncogenes are genes that drive cancer growth.

The amplification seems to happen in parallel with a decrease in function in another gene, ANXA7, located on chromosome 10, the researchers reported. A decrease in the function of ANXA7 shoots the EGFR oncogene into overdrive, contributing to the development and progression of malicious glioblastomas, they found.

Pasche also said that the particular research approach used in the studies might push forward research into other cancers.

"My feeling is that this approach is novel and may indeed be successful in other tumor types that so far have been reluctant to give us their code," he said. "This is an appealing and promising approach to identify the language of tumors."

More information

The U.S. National Cancer Institute has more on brain tumors.



SOURCES: Markus Bredel, M.D., Ph.D., director, Brain Tumor Institute Research Program, Feinberg School of Medicine, Northwestern University, Chicago; Boris Pasche, M.D., Ph.D., director, Division of Hematology/Oncology, and associate director, Comprehensive Cancer Center, University of Alabama at Birmingham; July 15, 2009, Journal of the American Medical Association


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. BurrellesLuce White Paper Gives Advice on Turning Twitter Connections Into Community Building Blocks
2. Meaningful Connections Offers Guidance, Case Examples for use of Electronic Health IT to Support Patient Centered Medical Home
3. Seniors Invited to Learn About Fraud Prevention at SCAN Connections Resource Center on April 28
4. American Cancer Society Launches Major Brand Revitalization Effort to Help Broaden Consumer Understanding and Connections
5. B. Brauns DoseTrac(TM) Software: Making Connections to Better Manage IV Therapy
6. Continua Health Alliance to Host Open Meeting at CONNECTIONS(TM) Tuesday, June 24th at 2:30 pm
7. Parks Associates Analysts Present Insights on Broadband, Digital Content, Advertising, Home Systems, and Digital Health at CONNECTIONS(TM)
8. Faulty brain connections may be responsible for social impairments in autism
9. Continua Health Alliance Provides Insight Into Next Generation of Digital Health at CONNECTIONS(TM)
10. Transportation: Making Connections Event to Explore Opportunities and Solutions for People With Disabilities
11. Study: Brain connections strengthen during waking hours, weaken during sleep
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Connections Key to Brain Tumor Growth
(Date:8/23/2017)... (PRWEB) , ... August 23, 2017 , ... ... vans, announced today that has been named to the 2017 Inc. 500|5000, an ... based on a three-year growth rate of 139 percent, marking the twelfth year ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... (SNAC) is holding an inaugural State of the Science Symposium in partnership ... Wednesday, Sept. 20, 2017. , This symposium provides a forum for global leaders ...
(Date:8/22/2017)... ... August 22, 2017 , ... ... to announce the addition of Zack Tisch as the firm’s new Consulting Services ... healthcare IT consulting firm’s national accounts, from assisting clients with initial vendor selection ...
(Date:8/22/2017)... ... ... Walk Away”: a captivating and romantic sequel to the romantic story of a ... creation of published author, Larry R. Sherman, a retired chemistry professor from the University ... well as four novels. , Though the book opens in 1947, when Edward ...
(Date:8/22/2017)... Carolina (PRWEB) , ... August 22, 2017 , ... ... advisor. Mr. Stewart is the Founder and Managing Member for t4 Leadership Development ... have become critical to his definition of “success”: physician leadership development, servant leadership, ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired the ... Lakewood, Colorado . The reputable clinic will continue ... PT, DPT with his staff of four clinicians. Lipkin received ... and brings over 10 years of experience with a strong ... Belmar PT marks the 10th PRN clinic in and around the ...
(Date:8/7/2017)... , Aug. 7, 2017 Diplomat Pharmacy, Inc. ... Joel Saban as president, effective Aug. 7, 2017. ... has decided to pursue other interests and will serve ... his tenure, Paul has served us in multiple leadership roles ... Pharmacy in Jun. 2015 and has provided decisive, strategic leadership ...
(Date:8/3/2017)... Aug. 3, 2017  Opioid addiction and other drugs ... healthcare costs and threatening outcomes, were problems taken on ... IVD industry that support them, met this week. This ... said that drugs of abuse, procalcitonin and acute kidney ... the organization,s 69th meeting in San Diego, ...
Breaking Medicine Technology: