Navigation Links
Gene Boosts Drinkers' Colon Cancer Risk
Date:12/19/2008

About a fifth of white Americans carry the mutation, researchers say

FRIDAY, Dec. 19 (HealthDay News) -- About a fifth of white Americans carry a gene mutation that leaves them at higher risk of colon cancer if they become chronic drinkers, a new study finds.

"If people drink alcohol chronically and have a certain genetic background, then they have an increased risk for large intestinal cancer -- colorectal cancer -- if they drink over a certain amount of alcohol every day," explained study co-author Dr. Helmut K. Seitz, a professor of medicine at Heidelberg University in Heidelberg, Germany.

Seitz and his colleagues were expected to publish their findings in the March issue of Alcoholism: Clinical and Experimental Research. The study was posted online Dec. 19.

Describing his team's work, Seitz said scientists have long known that chronic drinking ups risks for a wide range of cancers including breast, liver, esophageal and laryngeal malignancies.

In fact, the American Cancer Society already recommends limiting alcohol consumption to no more than one or two drinks per day for women and men, respectively, as a means of reducing overall cancer risk.

The new study focused on colon cancer. The team examined how disease risk might be affected by the varying speeds with which white individuals convert ethanol (alcohol) into a particularly metabolite called acetaldehyde.

This ethanol-to-acetaldehyde conversion process can be particularly rapid among those whites who carry a particular gene variant labeled ADH1C*1, the researchers noted.

"Acetaldehyde is a very toxic compound which changes and damages our DNA," Seitz noted. "And the speed of the change from ethanol to acetaldehyde is different in different individuals. So the idea is that if people have that gene which is responsible for a faster metabolism to acetaldehyde, then more of it would be produced in a shorter period of time, and more of would bind to our DNA. And that could increase colon cancer risk."

To explore this notion, the research team conducted genetic testing on 173 colon cancer patients, and compared their findings with tests conducted on 788 healthy people.

The result: Those men and women who possessed the ADH1C*1 gene were, in fact, at a genetically higher risk for developing colorectal cancer, although only when consuming more than 30 grams (about two drinks) of alcohol per day.

This translates to about a twofold to threefold increase in the risk for colon cancer for chronic drinkers with this particular genetic marker, Seitz said.

"But I have to state that, even so, the general risk is not tremendous," he noted. "Yes, it's certainly a significantly higher risk for those with the gene [about 20 percent of the general population] than for those without. But it's not an extremely huge risk."

"However, in any case, the message is very simple," added Seitz. "To be on the safe side, if you don't know your genetic background, be moderate in your alcohol consumption. That means you can have two drinks. But then be careful."

Dr. Marc Galanter, director of the division of alcoholism and substance abuse at New York University Langone Medical Center/Bellevue in New York City, noted that the current work serves to highlight another negative consequence of heavy alcohol use.

"Some develop liver disease," he said. "Others develop cardiac disease and, apparently, based on this study, some are more vulnerable to developing colorectal cancer. Research like this will help us understand which people are most vulnerable to the ill consequences of heavy drinking."

More information

There's more on the alcohol-cancer link at the American Cancer Society.



SOURCES: Helmut K. Seitz, M.D., professor, medicine, Heidelberg University, Heidelberg, Germany; Marc Galanter, M.D., professor, psychiatry, and director, division of alcoholism and substance abuse, New York University's Langone Medical Center/Bellevue, New York City; January 2009, Alcoholism: Clinical and Experimental Research


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Limiting School Snacks Boosts Fruit, Veggie Consumption
2. Cleveland Clinic Boosts Transparency, Makes Physician Disclosures Available Online
3. Transfusing Anemic Cancer Patients Boosts Clot Risk
4. Weight Boosts Older Womens Breast Cancer Risk
5. Psychological Counseling Boosts Breast Cancer Outcomes
6. Intervention program boosts survival in breast cancer patients
7. Drug Boosts Natural Growth Hormone in Seniors
8. Tailored Treatment Boosts Kidney Cancer Survival
9. Older Blood Boosts Chances of Infection in Transfusion Patients
10. Genetic Approach Boosts Yeast Infection Treatment
11. Western Diet Boosts Global Heart Attack Risk 30%
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Boosts Drinkers' Colon Cancer Risk
(Date:2/13/2016)... ... February 13, 2016 , ... When an Au Pair comes all the way ... they are in for and they are often worried things won’t go well. More often ... for. This year’s Au Pair of the Year winner’s all commented how their Au Pairs ...
(Date:2/12/2016)... ... February 12, 2016 , ... According to an ... beginning to account for a significant portion of hernia repairs throughout the United States. ... Beverly Hills Hernia Center notes that this trend has not only been expected, but ...
(Date:2/12/2016)... WA, and Washington, DC (PRWEB) , ... ... ... PATH and the Siemens Foundation today announced a new initiative—the Siemens Foundation-PATH ... for low-resource settings. The partnership will recruit top students from U.S. universities ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fixed Dose Combination ... 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination , Fixed dose combination ... garnering increased attention from all stakeholders in the development of new chemical entities. ...
(Date:2/12/2016)... CULVER CITY, California (PRWEB) , ... February 12, 2016 , ... ... to announce their participation in Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco ... and healthy way to stay hydrated before the big event. The invitation-only gifting suite, ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ARLZ ... Company will ring the Nasdaq Closing Bell at the ... at 4:00 p.m. ET on Tuesday, February ... Adrian Adams , will perform the honorary ... 4:00 p.m. ET.  A live webcast will be available ...
(Date:2/12/2016)... Ungarn, February 12, 2016 ... sich auf den ungedeckten medizinischen Bedarf bei ... Ergebnisse seines klinischen Forschungsprogramms bekannt. Das Programm, ... ergab Verbesserungen ihrer respiratorischen Funktionen und anderer ... , ein Medizintechnikunternehmen, das sich auf den ...
(Date:2/11/2016)... , Feb. 11, 2016 Stem cells ... are characterized by self-renewal and the capacity to differentiate ... relatively new discovery, as the first mouse embryonic stem ... was not until 1995 that the first culturing of ... stem cells were not produced until 2006 As a ...
Breaking Medicine Technology: