Navigation Links
Gene Behind Psoriasis Identified, Researchers Say
Date:4/19/2012

THURSDAY, April 19 (HealthDay News) -- Scientists say they've identified the first gene directly linked to the most common form of psoriasis, known as plaque psoriasis.

"We have searched for almost two decades to find a single gene linked to plaque psoriasis," study senior author Anne Bowcock, professor of genetics at Washington University School of Medicine in St. Louis, said in a university news release. "Individually, the rare mutations we have found likely confer a high risk for the disease, and we think they will be important in the search to find new, more effective treatments."

In conducting the study, researchers used cutting-edge DNA technology to uncover a rare mutation in the CARD14 gene in a large family of European descent with a high prevalence of plaque psoriasis and psoriatic arthritis. They also found the mutation among multiple members of an extended family from Taiwan who had the condition, which is characterized by dry, raised, red patches covered with silvery scales.

The genetic mutation was also identified in a 3-year-old girl with a severe and rare form of psoriasis, but in this case the condition was not inherited. She developed the condition after being treated for a staph infection.

"This is significant because it tells us that CARD14 alone plus an environmental trigger is enough to cause psoriasis," Bowcock explained. "You don't need anything else. This really highlights the importance of finding rare mutations for common diseases like psoriasis."

The findings suggest that immune cells are only a secondary cause of psoriasis. Skin defects, the researchers stated, are the main culprit behind the condition.

Noting that the family members studied who had psoriatic arthritis also had the CARD14 mutation, the study authors suggested the rare mutation may also be involved in at least one other form of psoriasis as well as a debilitating form of arthritis.

"Now, we have a much clearer picture of what is happening in psoriasis," Bowcock concluded. "And now with all kinds of new therapeutic targets that lie within the CARD14 pathway, the field is wide open."

The research was released online in advance of print publication in two separate papers in the May 4 issue of the American Journal of Human Genetics.

About 7.5 million Americans have psoriasis, the study authors noted.

More information

The U.S. National Library of Medicine has more about psoriasis.

-- Mary Elizabeth Dallas

SOURCE: Washington University School of Medicine in St. Louis, news release, April 17, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Insects Behind Chagas Disease Are Feeding on Humans in the U.S.
2. A culprit behind brain tumor resistance to therapy
3. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
4. Researchers Spot Genes Behind Macular Degeneration
5. Study Finds Gene Behind Inherited Cases of Enlarged Heart
6. U.S. Doctors Behind Face Transplants Give Details of Procedure
7. Advantages and motivations uncertain behind use of brachytherapy for breast cancer radiotherapy
8. Supercomputer reveals new details behind drug-processing protein model
9. Researchers search for culprit behind dry eyes, mouths and more
10. Unvaccinated Kids Behind Largest U.S. Measles Outbreak in Years: Study
11. Antioxidants Not Behind Red Wines Healthy Effect on Heart: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Behind Psoriasis Identified, Researchers Say
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: