Navigation Links
Gene Behind Psoriasis Identified, Researchers Say

THURSDAY, April 19 (HealthDay News) -- Scientists say they've identified the first gene directly linked to the most common form of psoriasis, known as plaque psoriasis.

"We have searched for almost two decades to find a single gene linked to plaque psoriasis," study senior author Anne Bowcock, professor of genetics at Washington University School of Medicine in St. Louis, said in a university news release. "Individually, the rare mutations we have found likely confer a high risk for the disease, and we think they will be important in the search to find new, more effective treatments."

In conducting the study, researchers used cutting-edge DNA technology to uncover a rare mutation in the CARD14 gene in a large family of European descent with a high prevalence of plaque psoriasis and psoriatic arthritis. They also found the mutation among multiple members of an extended family from Taiwan who had the condition, which is characterized by dry, raised, red patches covered with silvery scales.

The genetic mutation was also identified in a 3-year-old girl with a severe and rare form of psoriasis, but in this case the condition was not inherited. She developed the condition after being treated for a staph infection.

"This is significant because it tells us that CARD14 alone plus an environmental trigger is enough to cause psoriasis," Bowcock explained. "You don't need anything else. This really highlights the importance of finding rare mutations for common diseases like psoriasis."

The findings suggest that immune cells are only a secondary cause of psoriasis. Skin defects, the researchers stated, are the main culprit behind the condition.

Noting that the family members studied who had psoriatic arthritis also had the CARD14 mutation, the study authors suggested the rare mutation may also be involved in at least one other form of psoriasis as well as a debilitating form of arthritis.

"Now, we have a much clearer picture of what is happening in psoriasis," Bowcock concluded. "And now with all kinds of new therapeutic targets that lie within the CARD14 pathway, the field is wide open."

The research was released online in advance of print publication in two separate papers in the May 4 issue of the American Journal of Human Genetics.

About 7.5 million Americans have psoriasis, the study authors noted.

More information

The U.S. National Library of Medicine has more about psoriasis.

-- Mary Elizabeth Dallas

SOURCE: Washington University School of Medicine in St. Louis, news release, April 17, 2012

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Insects Behind Chagas Disease Are Feeding on Humans in the U.S.
2. A culprit behind brain tumor resistance to therapy
3. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
4. Researchers Spot Genes Behind Macular Degeneration
5. Study Finds Gene Behind Inherited Cases of Enlarged Heart
6. U.S. Doctors Behind Face Transplants Give Details of Procedure
7. Advantages and motivations uncertain behind use of brachytherapy for breast cancer radiotherapy
8. Supercomputer reveals new details behind drug-processing protein model
9. Researchers search for culprit behind dry eyes, mouths and more
10. Unvaccinated Kids Behind Largest U.S. Measles Outbreak in Years: Study
11. Antioxidants Not Behind Red Wines Healthy Effect on Heart: Study
Post Your Comments:
Related Image:
Gene Behind Psoriasis Identified, Researchers Say
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television series, "Voices in ... that delves into an array of issues that are presently affecting Americans. Dedicated to ... dialogue, this show is changing the subjects consumers focus on, one episode at a ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men ... prominent nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown ... helped advance the healthcare industry as a whole through their advocacy and professional ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients ... central Michigan, have come together on Thanksgiving Day to share the things that ... viewing on the Serenity Point YouTube channel, patients displayed what they wrote on ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... workshops to discuss bioavailability and the need to integrate dose form selection in ... collaboration with OBN, the membership organization supporting and bringing together the UK’s emerging ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes ... titles work with any font, giving users limitless opportunities to stylize and create ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... -- --> --> ... potential to save costs, improve treatment quality and accelerate ... exploited as yet. Here, particular emphasis is placed on ... tablet or directly at the patients, bedside. ... -->      (Photo: ) ...
(Date:11/27/2015)... -- Research and Markets ( ) has announced ... 2015-2019" report to their offering. ... the author the present scenario and growth prospects of ... the market size, the report considers revenue generated from ... and copper IUDs. The report forecasts the global intrauterine ...
(Date:11/26/2015)... 26, 2015 Un nuevo enfoque ... para el cáncer avanzado.   --> ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... inmunoterapia con la terapia fotodinámica de Bremachlorin para el ... . --> Clinical Cancer Research . ...
Breaking Medicine Technology: