Navigation Links
Gene Behind Psoriasis Identified, Researchers Say
Date:4/19/2012

THURSDAY, April 19 (HealthDay News) -- Scientists say they've identified the first gene directly linked to the most common form of psoriasis, known as plaque psoriasis.

"We have searched for almost two decades to find a single gene linked to plaque psoriasis," study senior author Anne Bowcock, professor of genetics at Washington University School of Medicine in St. Louis, said in a university news release. "Individually, the rare mutations we have found likely confer a high risk for the disease, and we think they will be important in the search to find new, more effective treatments."

In conducting the study, researchers used cutting-edge DNA technology to uncover a rare mutation in the CARD14 gene in a large family of European descent with a high prevalence of plaque psoriasis and psoriatic arthritis. They also found the mutation among multiple members of an extended family from Taiwan who had the condition, which is characterized by dry, raised, red patches covered with silvery scales.

The genetic mutation was also identified in a 3-year-old girl with a severe and rare form of psoriasis, but in this case the condition was not inherited. She developed the condition after being treated for a staph infection.

"This is significant because it tells us that CARD14 alone plus an environmental trigger is enough to cause psoriasis," Bowcock explained. "You don't need anything else. This really highlights the importance of finding rare mutations for common diseases like psoriasis."

The findings suggest that immune cells are only a secondary cause of psoriasis. Skin defects, the researchers stated, are the main culprit behind the condition.

Noting that the family members studied who had psoriatic arthritis also had the CARD14 mutation, the study authors suggested the rare mutation may also be involved in at least one other form of psoriasis as well as a debilitating form of arthritis.

"Now, we have a much clearer picture of what is happening in psoriasis," Bowcock concluded. "And now with all kinds of new therapeutic targets that lie within the CARD14 pathway, the field is wide open."

The research was released online in advance of print publication in two separate papers in the May 4 issue of the American Journal of Human Genetics.

About 7.5 million Americans have psoriasis, the study authors noted.

More information

The U.S. National Library of Medicine has more about psoriasis.

-- Mary Elizabeth Dallas

SOURCE: Washington University School of Medicine in St. Louis, news release, April 17, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Insects Behind Chagas Disease Are Feeding on Humans in the U.S.
2. A culprit behind brain tumor resistance to therapy
3. Researchers ID gene behind primary cervical dystonia, a neck-twisting disorder
4. Researchers Spot Genes Behind Macular Degeneration
5. Study Finds Gene Behind Inherited Cases of Enlarged Heart
6. U.S. Doctors Behind Face Transplants Give Details of Procedure
7. Advantages and motivations uncertain behind use of brachytherapy for breast cancer radiotherapy
8. Supercomputer reveals new details behind drug-processing protein model
9. Researchers search for culprit behind dry eyes, mouths and more
10. Unvaccinated Kids Behind Largest U.S. Measles Outbreak in Years: Study
11. Antioxidants Not Behind Red Wines Healthy Effect on Heart: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Behind Psoriasis Identified, Researchers Say
(Date:11/30/2016)... ... November 30, 2016 , ... The Fertility Centers of ... a Cigna Infertility Center of Excellence. The Cigna Center of Excellence recognizes participating ... honor to be designated a Cigna Infertility Center of Excellence," said Fertility Centers ...
(Date:11/30/2016)... ... 2016 , ... "I hate when the mixture of saliva and toothpaste runs ... inventor from Bridgewater, N.J. "I thought that there had to be a way to ... the patent-pending DEFLECTOR to prevent saliva and toothpaste from running down the brush handle ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For Discovery, ... the opening of a new eating disorder treatment center location in Palm Beach ... adults and adolescents, both males and females ages 10 and older with eating ...
(Date:11/30/2016)... MA (PRWEB) , ... November 30, 2016 , ... ... for treating injured workers have been a focus of public policymakers and system ... Compensation Research Institute (WCRI) released its Medical Price Index for Workers’ Compensation, ...
(Date:11/30/2016)... ... November 30, 2016 , ... The Clinical Data Interchange Standards ... Binding Guidance goes into effect next month. Sponsors whose studies start after December ... Standards Catalog. The current FDA Data Standards Catalog specifies the use of CDISC ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... bioLytical Laboratories (das "Unternehmen"), ein Weltführer bei schnellen ... HIV-Selbsttests  in einer Version mit geringeren Kosten einzuführen.  ... ... New: INSTI Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444833 ) ...
(Date:11/30/2016)... Research and Markets has announced the addition of the ... report to their offering. ... The cerebrospinal fluid (CSF) acts as ... is circulated though the brain and its ventricles, the spine and the ... the brain changes significantly. As a result, intracranial ...
(Date:11/30/2016)...  Millennium Dental Technologies, Inc. announced that it has again ... of the State of California , County ... California,s Uniform Trade Secrets act, Unfair ... practices which are untrue and misleading, as well as other ... the second time in three years that Millennium found it ...
Breaking Medicine Technology: