Navigation Links
Gene Behind Gaucher Disease a Player in Parkinson's
Date:10/21/2009

ky said.

Several smaller studies have suggested the genetic link between the two conditions, "but there have always been questions based on their size and controls," Sidransky said. "Once and for all, we have put together a large enough number so that no one will question the results."

The study she led involved 16 institutions around the world. A listing of the institutions and researchers filled a complete page on the journal in fine print.

Those researchers examined the frequency of GBA variants in 5,691 people with Parkinson's disease, including 780 Ashkenazi Jews, an ethnic group in which Gaucher disease is more common. Their data was matched with genetic information from 4,898 disease-free individuals, including 387 Ashkenazi Jews.

At least one of two common GBA variants was found in 3.2 percent of the people with Parkinson's disease, but only 0.6 percent of the disease-free individuals. Among the Ashkenazi participants, 15.3 percent of those with Parkinson's disease carried a GBA variant, compared to 3.4 percent of disease-free Ashkenazi individuals.

In addition to increasing the risk of Parkinson's disease, presence of a GBA variant was associated with early onset of the condition, four to five years sooner than ordinarily seen, the study found.

"Its importance is that it may indicate a new pathway to explore for the etiology [cause] of Parkinson's disease, and ultimately a target for drug discovery," said Dr. Karen Marder, a professor of neurology at Columbia University Medical Center, and one of the researchers in the trial.

The discovery raises some possible issues about genetic counseling, Marder said, but more work must be done before that can influence medical practice.

"This is among the most important susceptibility factors for Parkinson's that has ever been discovered, but it is premature to talk about using it in clinical practice," she said.

More informati
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Genes behind increasingly common form of cancer identified
2. Producers of New PBS Series Joined By Experts to Reveal Science Behind Happiness
3. Max Muscle Franchising Is Fueled By The Passion Behind The Brand
4. Brain Training Keeps Older Drivers Safe Behind the Wheel
5. Innovative New Book Series Encourages Kids to Go Behind Their Parents' Backs and Listen to Experts on Important Health and Wellness, Education, Personal Finance and Nutrition
6. Leave Worries Behind When Packing for Vacation
7. Researchers Discover the Tale Behind Short Dogs
8. Mylan Reiterates and Stands Behind Its 48-Year Commitment and Track Record of Quality
9. Michael Jackson Get the Medical Facts Behind the Headlines at CelebrityDiagnosis.com
10. Is Your Teenager Using Prescription Drugs Behind Your Back? TestCountry Drug Test Panel Numbers Tally with NIDA Fact Sheet Reports on Prescription Drug A
11. Businesses, Unions, Veteran Party Leaders Unite Behind Bipartisan, Consensus Approach to Health Care Reform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Medicine researchers have been awarded two-year grants for their ... this month. Of the 110 initial submissions to the ... Program, only four projects were funded, three of which ... Powell, M.D., Ph.D.; G. William Wong, Ph.D.; and Elias ... of oncology, will use his $500,000 proof of principle ...
(Date:4/18/2014)... French . ... medicine. A team led by Ludwik Leibler from the ... Didier Letourneur from the Laboratoire Recherche Vasculaire Translationnelle (INSERM/Universits ... the principle of adhesion by aqueous solutions of nanoparticles ... and tissues. This easy-to-use gluing method has been tested ...
(Date:4/17/2014)... targets that could be used to provide relief ... London made the discovery when researching how pain ... body. , Dr Marzia Malcangio said: "We have ... and our findings could help chemotherapy patients who ... side effect of some chemotherapy drugs (such as ...
(Date:4/17/2014)... Two recent papers by a University of Colorado ... scientists develop treatments or vaccines for Dengue fever, ... other disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, ... the School of Medicine and an early career ... colleagues recently published articles in the scholarly journals ...
(Date:4/17/2014)... (April 17, 2014) Doctors who treat patients ... lymphangioleiomyomatosis (LAM) can face an agonizing treatment decision. ... the disease and help relieve shortness of breath. ... and sirolimus can cause potentially fatal complications following ... Dr. Daniel Dilling, medical director of Loyola University ...
Breaking Medicine News(10 mins):Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:New pain relief targets discovered 2Health News:CU researchers discover target for treating dengue fever 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3
... researchers will lead a $10.25 million effort to study ... need for dialysis. The five-year project supports research ... that, though rare, generates an enormous individual and societal ... to nearly 12 percent of cases of kidney failure, ...
... , , , ... by wearing a purple LFA wristband until there is an FDA-approved medication ... It,s been 50 years since the U.S. Food and Drug Administration (FDA) ... President! To highlight the need for safer, more tolerable, and effective medications, ...
... NEW YORK, Sept. 22 The Global Network ... partnership with the Miss Universe Organization aimed at educating millions ... control and eliminate neglected tropical diseases across the region. ... time in their home countries participating in education and mass ...
... , , SAN MARCOS, Calif., ... NAII ), a leading formulator, manufacturer and marketer of customized nutritional ... per diluted share on net sales from continuing operations of $73.9 ... fiscal 2009 results include a net loss from discontinued operations of ...
... , , NEW YORK, Sept. 22 ... of specialty insurance and insurance-related products and services, will release 2009 third ... The news release will be available on Assurant,s Web site at ... broadcast its 2009 third quarter conference call at 9:00 a.m. ET on ...
... ELM GROVE, Wis., Sept. 22 A free ... Factor in HAI , is being sponsored by Compirion Healthcare Solutions, ... Wisconsin. Dates and times, along with registration information, can be found ... webinar are the main causes of non-compliance with hospital hand-washing ...
Cached Medicine News:Health News:Kidney advocates launch $10.25 million effort to examine cause of kidney failure 2Health News:The Lupus Foundation of America, Inc. Asks Supporters to Band Together for Lupus(SM) 2Health News:Miss Universe Organization, Global Network for Neglected Tropical Diseases Join Forces to Eliminate Neglected Tropical Diseases in the Americas 2Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 2Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 3Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 4Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 5Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 6Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 7Health News:Natural Alternatives International, Inc. Announces Fiscal 2009 Q4 and Full Year Results 8Health News:Assurant to Announce 2009 Third Quarter Results Oct. 28, 2009 and Host Webcast Conference Call Oct. 29 2Health News:Free Webinar on Helping Hospitals Control Healthcare-Associated Infections by Improving Hand Hygiene 2Health News:Free Webinar on Helping Hospitals Control Healthcare-Associated Infections by Improving Hand Hygiene 3
(Date:1/15/2014)... wearable injector slightly larger than an Oreo cookie may soon ... drugs in the large doses required to treat a wide ... genetic disorders.  An emerging biologic drugs market ... analysts.   Many of these drugs will require a new type ...
(Date:1/14/2014)... 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company ... Progressive Home Medical Equipment, Inc. ("Progressive") of Clarion, ... the acquisition were not disclosed. Progressive is ... wide range of sleep, mobility, and respiratory products to customers ...
(Date:1/14/2014)...   Oligomerix, Inc. , a privately held company pioneering ... (AD) and related neurodegenerative disorders, announced today the relocation ... as of January 15, 2014 and expanded ... Medical College. Oligomerix, which is focused on ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... Inc. today announced that the U.S. Food and Drug ... (estradiol valerate and estradiol valerate/dienogest) tablets for the treatment ... by any diagnosed conditions of the uterus (womb), in ... With this approval, Natazia is the first and only ...
... March 14, 2012  Nile Therapeutics, Inc. (OTCQB: NLTX), ... heart failure patients, today announced the schedule of ... American College of Cardiology (ACC) 61th Scientific Session, ... Monday, March 26, 2012 Time: 10:00 AM -12:00 PM ...
Cached Medicine Technology:U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 2U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 3U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 4Nile Therapeutics Announces Upcoming Data Presentation at the American College of Cardiology Annual Scientific Meeting 2