Navigation Links
Gender Plays Role in Kidney Transplant Outcomes
Date:7/4/2008

Increased rate of graft failure when male organs donated to females, study finds

FRIDAY, July 4 (HealthDay News) -- Women who receive kidneys from males have a higher rate of graft failure than other donor-recipient combinations, and gender should be considered when choosing donor matches, a new Swiss study says.

Researchers at University Hospital Basel analyzed data on 195,516 people in Europe who received kidneys from deceased donors between 1985 and 2004, and identified complex gender interactions. Graft loss was more common with kidneys from female donors than with kidneys from male donors after both one year and 10 years. Female recipients had a lower rate of graft failure between the end of the first year and the end of the 10th year.

Compared with all other gender combinations, transplantation of male donor kidneys into female patients was associated with an 8 percent increased risk of graft failure and an 11 percent increased risk of graft failure-related death in the first year. Between two and 10 years, the rates were 6 percent and 10 percent.

"Our multi-variable analysis showed that transplantation of kidneys from male donor into female recipients caused an increased rate of graft failure, which suggests an immunological H-Y effect in renal transplantation during the first year after transplantation that extends to 10 years of follow-up ... Consideration of sex should be integrated into future prospective analyses and decisions on organ allocation," the researchers wrote.

They noted that male recipients may benefit from bigger male kidneys, with their higher number of nephrons, which are the basic structural and functional units of the kidney. Women may not need the same number of nephrons as men, and could benefit from the lower likelihood of rejection associated with a kidney from a female donor.

The study was published in this week's issue of The Lancet.

"H-Y antigens can no longer be ignored in the setting of solid-organ transplantation. A lot of work still needs to be done on the actual antigens and the immunological responses that might be associated with rejection. However, the science is still too premature to suggest that allocation schemes from dead donors or selection of living donors for transplantation take notice of this effect, in view of the good long-term success with sex-mismatched allografts and the limited access to organs," Dr. Connie L Davis, from the division of nephrology and transplantation at the University of Washington, Seattle, wrote in an accompanying comment.

More information

The National Kidney Foundation has more about kidney transplant.



-- Robert Preidt



SOURCE: The Lancet, news release, July 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Research says doctors gender may hinder early diagnosis of heart disease in women
2. PA Health Department Survey Shows Impact of Income, Gender, Other Factors on Health and Access to Health Care
3. Survey shows gender differences are factor when surgeons in training choose a subspecialty
4. Race, Gender Affect Laryngeal Cancer Survival
5. Climate change, gender differences, health among EurekAlert! 10 Most Popular Stories in 2007
6. Fungus Sheds Light on Development of Human Genders
7. Iowa State University researchers work on gender, temperature link in reptiles published in Nature
8. QED International Associates Announces Changes to the HealthShares(TM) GI/Gender Health Index
9. Gender differences in language appear biological
10. Gender Bias at Play in Treatment of Knee Osteoarthritis
11. Gender bias may affect care of people with osteoarthritis, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest ... . , Millions of individuals in the United States and Canada wear eyeglasses. Once ... to both correct vision and make a fashion statement. Even celebrities use glasses as ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... Oticon , industry leaders in advanced ... launch of Oticon Opn ™, the world,s first ... of possibilities for IoT devices.      (Photo: ... Oticon introduces a number of ,world firsts,: ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
(Date:6/23/2016)... -- The National Pharmaceutical Council (NPC) today announced that ... organization as its newest member.  ... and chief scientific officer, Mallinckrodt Pharmaceuticals, will serve ... of Directors. ... in support of our efforts to conduct research ...
Breaking Medicine Technology: