Navigation Links
Gender Plays Role in Kidney Transplant Outcomes
Date:7/4/2008

Increased rate of graft failure when male organs donated to females, study finds

FRIDAY, July 4 (HealthDay News) -- Women who receive kidneys from males have a higher rate of graft failure than other donor-recipient combinations, and gender should be considered when choosing donor matches, a new Swiss study says.

Researchers at University Hospital Basel analyzed data on 195,516 people in Europe who received kidneys from deceased donors between 1985 and 2004, and identified complex gender interactions. Graft loss was more common with kidneys from female donors than with kidneys from male donors after both one year and 10 years. Female recipients had a lower rate of graft failure between the end of the first year and the end of the 10th year.

Compared with all other gender combinations, transplantation of male donor kidneys into female patients was associated with an 8 percent increased risk of graft failure and an 11 percent increased risk of graft failure-related death in the first year. Between two and 10 years, the rates were 6 percent and 10 percent.

"Our multi-variable analysis showed that transplantation of kidneys from male donor into female recipients caused an increased rate of graft failure, which suggests an immunological H-Y effect in renal transplantation during the first year after transplantation that extends to 10 years of follow-up ... Consideration of sex should be integrated into future prospective analyses and decisions on organ allocation," the researchers wrote.

They noted that male recipients may benefit from bigger male kidneys, with their higher number of nephrons, which are the basic structural and functional units of the kidney. Women may not need the same number of nephrons as men, and could benefit from the lower likelihood of rejection associated with a kidney from a female donor.

The study was published in this week's issue of The Lancet.

"H-Y antigens can no longer be ignored in the setting of solid-organ transplantation. A lot of work still needs to be done on the actual antigens and the immunological responses that might be associated with rejection. However, the science is still too premature to suggest that allocation schemes from dead donors or selection of living donors for transplantation take notice of this effect, in view of the good long-term success with sex-mismatched allografts and the limited access to organs," Dr. Connie L Davis, from the division of nephrology and transplantation at the University of Washington, Seattle, wrote in an accompanying comment.

More information

The National Kidney Foundation has more about kidney transplant.



-- Robert Preidt



SOURCE: The Lancet, news release, July 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Research says doctors gender may hinder early diagnosis of heart disease in women
2. PA Health Department Survey Shows Impact of Income, Gender, Other Factors on Health and Access to Health Care
3. Survey shows gender differences are factor when surgeons in training choose a subspecialty
4. Race, Gender Affect Laryngeal Cancer Survival
5. Climate change, gender differences, health among EurekAlert! 10 Most Popular Stories in 2007
6. Fungus Sheds Light on Development of Human Genders
7. Iowa State University researchers work on gender, temperature link in reptiles published in Nature
8. QED International Associates Announces Changes to the HealthShares(TM) GI/Gender Health Index
9. Gender differences in language appear biological
10. Gender Bias at Play in Treatment of Knee Osteoarthritis
11. Gender bias may affect care of people with osteoarthritis, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went ... creation of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age ... at 19 years of age, he joined the Navy and got married right out of ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: ... by faith. “Knowledge is God’s Lighthouse” is the creation of published author, Gene Gaapf, ... and poetry collections. , “I have been writing since high school and have ...
(Date:1/19/2017)... ... , ... Next week after January 20th, the fear for many is that ... health needs of over 30 million. Many interviews with Dr. Carol Francis at the ... servants were suppose to prioritize. Interviews provided below. , Among those present ...
(Date:1/19/2017)... ... 2017 , ... WhoHaha , a digital media company dedicated to creating ... to produce a three-part video series that uses humor to highlight ways to improve ... of AHA’s Healthy For Good™ movement, which is designed to inspire all Americans to ...
(Date:1/19/2017)... Scotch Plains, NJ (PRWEB) , ... January 19, ... ... a board certified dermatologist by the American Board of Dermatology and fellowship trained ... Institute of the National Institutes of Health, Dr. Li completed his internship in ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , Jan. 20, 2017  Ethicon ... acquired Megadyne Medical Products, Inc., a privately ... and markets electrosurgical tools used in operating ... intelligence of Ethicon,s* advanced energy devices with ... a major step forward in Ethicon,s goal ...
(Date:1/20/2017)... , Jan. 20, 2017  Palladian Health, a ... announced the launch of an opioid management program ... on opioids and helps stem the growing tide ... prescribed to treat chronic non-cancer pain (back pain, ... risks and lack of evidence regarding long-term effectiveness. ...
(Date:1/20/2017)... , January 20, 2017 Avillion LLP, ... appointment of Mark Weinberg , MD MBA as Chief Medical ... , USA . ... Dr Weinberg has spent more than 17 years ... 20" pharma companies to micro-cap biotech. Over the course of his ...
Breaking Medicine Technology: