Navigation Links
Gender Plays Role in Kidney Transplant Outcomes
Date:7/4/2008

Increased rate of graft failure when male organs donated to females, study finds

FRIDAY, July 4 (HealthDay News) -- Women who receive kidneys from males have a higher rate of graft failure than other donor-recipient combinations, and gender should be considered when choosing donor matches, a new Swiss study says.

Researchers at University Hospital Basel analyzed data on 195,516 people in Europe who received kidneys from deceased donors between 1985 and 2004, and identified complex gender interactions. Graft loss was more common with kidneys from female donors than with kidneys from male donors after both one year and 10 years. Female recipients had a lower rate of graft failure between the end of the first year and the end of the 10th year.

Compared with all other gender combinations, transplantation of male donor kidneys into female patients was associated with an 8 percent increased risk of graft failure and an 11 percent increased risk of graft failure-related death in the first year. Between two and 10 years, the rates were 6 percent and 10 percent.

"Our multi-variable analysis showed that transplantation of kidneys from male donor into female recipients caused an increased rate of graft failure, which suggests an immunological H-Y effect in renal transplantation during the first year after transplantation that extends to 10 years of follow-up ... Consideration of sex should be integrated into future prospective analyses and decisions on organ allocation," the researchers wrote.

They noted that male recipients may benefit from bigger male kidneys, with their higher number of nephrons, which are the basic structural and functional units of the kidney. Women may not need the same number of nephrons as men, and could benefit from the lower likelihood of rejection associated with a kidney from a female donor.

The study was published in this week's issue of The Lancet.

"H-Y antigens can no longer be ignored in the setting of solid-organ transplantation. A lot of work still needs to be done on the actual antigens and the immunological responses that might be associated with rejection. However, the science is still too premature to suggest that allocation schemes from dead donors or selection of living donors for transplantation take notice of this effect, in view of the good long-term success with sex-mismatched allografts and the limited access to organs," Dr. Connie L Davis, from the division of nephrology and transplantation at the University of Washington, Seattle, wrote in an accompanying comment.

More information

The National Kidney Foundation has more about kidney transplant.



-- Robert Preidt



SOURCE: The Lancet, news release, July 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Research says doctors gender may hinder early diagnosis of heart disease in women
2. PA Health Department Survey Shows Impact of Income, Gender, Other Factors on Health and Access to Health Care
3. Survey shows gender differences are factor when surgeons in training choose a subspecialty
4. Race, Gender Affect Laryngeal Cancer Survival
5. Climate change, gender differences, health among EurekAlert! 10 Most Popular Stories in 2007
6. Fungus Sheds Light on Development of Human Genders
7. Iowa State University researchers work on gender, temperature link in reptiles published in Nature
8. QED International Associates Announces Changes to the HealthShares(TM) GI/Gender Health Index
9. Gender differences in language appear biological
10. Gender Bias at Play in Treatment of Knee Osteoarthritis
11. Gender bias may affect care of people with osteoarthritis, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... New York, NY (PRWEB) , ... March 23, 2017 , ... 82% of adults are ... every 3 kids do not brush their teeth the minimum two times a day that ... teeth; with students missing 51 million hours of school and adults missing 164 million hours ...
(Date:3/23/2017)... Los Angeles, CA (PRWEB) , ... March 23, ... ... Series A funding investment in Los Angeles based healthcare technology company California Healthcom ... group’s portfolio into the US, and healthcare arena. With headquarters in California, CHG ...
(Date:3/23/2017)... ... 2017 , ... After raising more than $1.135 million ($1,479,231 AUD) from nearly ... in crowdfunding history, has established a U.S. Headquarters in New York City, FaceCradle ... , “We’re excited to be operating on U.S. shores, where most of our initial ...
(Date:3/23/2017)... ... 23, 2017 , ... According to the National Sleep Foundation , poor ... the only cause of the sunken-eye look, which can include dark circles or bags ... poor health are likely due to genetics, dehydration, allergies, and losing fat beneath the ...
(Date:3/23/2017)... ... March 23, 2017 , ... The American Board of Quality Assurance ... Anniversary of ABQAURP’s dedication to Health Care Quality and Management and Patient Safety. , ... only to the association, but also to the Health Care Quality and Patient Safety ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... VANCOUVER, British Columbia , March 23, 2017 /PRNewswire/ ... "Company" or "Sophiris"), a clinical late-stage biopharmaceutical company developing ... announced that data from its successful Phase 2a study ... treatment for localized prostate cancer, will be presented as ... nd Annual European Association of Urology in ...
(Date:3/23/2017)... 2017  Ethicon* today announced the completion of ... held medical device company that manufactures and markets ... treatment of Gastroesophageal Reflux Disease (GERD). This acquisition ... portfolio of minimally invasive options for patients suffering ... of the transaction have not been disclosed. ...
(Date:3/23/2017)... LITTLE SILVER, N.J. , March 23, 2017 ... device company, today announced that it has kicked ... in-growth into their 3D printed bone segments. ... of Engineering, "Our unique variable honeycomb lattice structures ... bone in-growth as compared to current allograft wedges ...
Breaking Medicine Technology: