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Gender, insurance type tied to HPV infection in laryngeal cancer patients
Date:9/14/2011

V prevalence and how HPV might impact survival.

The Henry Ford study takes a closer look at HPV prevalence based on race, gender and insurance type, as well as stage and survival for laryngeal cancer patients.

The study group included information and tissue samples for 79 patients, of which 60 were male and 19 were female. The patients were categorized into two groups: no treatment and treatment (radiation and/or chemotherapy).

Most notably, 41% percent of the study group was African American, and the majority of the study group (95%) had a history of smoking. The study found HPV-positive status for laryngeal cancer to be significantly tied to gender, with 34% of men and 5% of women having HPV.

Insurance type also was associated with HPV status. The majority of private insurance patients were found to have HPV, while the Medicare group had far more HPV-negative patients than HPV-positive patients.

HPV had a lower prevalence in African American patients. It was detected in 16% of African Americans as compared to 33% of Caucasian in the study.

"It's very revealing what's embedded in this study, particularly for African American patients," says co-author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

"We know that African Americans are disproportionately diagnosed with late-stage cancer and have worse outcomes than Caucasians. This study really builds on sexual behavioral lifestyle-related evidence that may be contributing to outcomes, especially since there's a significant difference between HPV status in African Americans and Caucasian populations."

The study results also suggest that, similar to oropharyngeal cancer research, laryngeal cancer patients with HPV have better survival and tend to respond better to chemotherapy and radiation treatments than patients who do not have HPV.

The researchers say, however
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Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

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