Navigation Links
Geisinger and Celera to collaborate on liver disease test
Date:2/19/2008

DANVILLE, PA and ALAMEDA, CA February 19, 2008 Geisinger Health System and Celera (NYSE:CRA), an Applera Corporation business, today announced that they have entered into a research collaboration with the aim of developing a diagnostic assay for the increased risk of non-alcoholic steatohepatitis (NASH). The collaboration will evaluate Celeras numerous genetic findings in liver diseases, including the Cirrhosis Risk Score, in the Geisinger bank of more than 600 liver tissue and blood case-control samples donated from patients who have undergone bariatric weight loss surgery. The Geisinger biorespository is among the largest of its kind within a research setting. Financial terms of this multi-year collaboration were not disclosed.

Non-alcoholic fatty liver disease (NAFLD) is a condition where there is accumulation of excess fat in the liver. NAFLD is usually asymptomatic and, as a result, many people dont know they have the condition until substantial liver damage has occurred. NASH represents an advanced stage of the disease when the accumulated fat results in significant inflammation and scarring. This occurs in approximately a quarter of the patients and can lead to cirrhosis. Ultimately, a liver transplant may be required. Knowledge of those individuals most likely to suffer from this advanced disease could enable closer monitoring of these individuals, leading to overall improved disease management.

NAFLD is linked to metabolic syndrome characterized by diabetes, obesity, and cardiovascular disease. The American College of Gastroenterology estimates that NAFLD affects 2 to 5 percent of Americans and 10 to 20 percent of those who are obese. Elevated serum aminotransferase levels and evidence of insulin resistance are suggestive of early stages of the disease with ultrasound and liver biopsy used in the diagnosis of the disease.

Even though there are no approved medications for the treatment of NAFLD/ NASH, clinicians strongly encourage patients to lose weight by adopting a low-carbohydrate, low-fat diet and recommend more aggressive control of the often coincident diabetes, dyslipidemia and hypertension, explained Geisinger scientist Glenn S. Gerhard, M.D.

Understanding the natural history of NAFLD and NASH, especially identification of those patients with or at risk for NASH represents a critical unmet diagnostic need in liver disease, said Scott Friedman M.D., Fishberg Professor of Medicine and Chief of Liver Diseases at the Mount Sinai School of Medicine, and a member of the Charles Bronfman Institute for Personalized Medicine. Associations of disease with various gene variants are beginning to provide keen insight into disease mechanisms that may be shared by multiple diseases.

Nonalcoholic fatty liver disease has proven extremely difficult to study, in part because investigators dont have access to well-characterized samples with information on patient outcomes. Multiple sample sets are vital for the replication of genetic association studies, said John Sninsky, Ph.D., Vice President, Discovery Research, at Celera.

"Currently a needle liver biopsy is the only way to definitively diagnose the disease so the development of a blood test to detect NAFLD risk would be a tremendous benefit to patients," said Christopher D. Still, DO, Director of the Center for Nutrition and Weight Management and physician researcher on the project.

Jim Peters, Geisinger Ventures Senior Director and CEO of MedMining, Geisingers data business, noted, Together, Geisinger and Celera bring a synergy of experience and expertise to the table.

According to Geisinger Ventures Director Bryan Allinson, This academic entrepreneurial collaboration will help advance personalized medicine to practical clinical use, which is all part of Abigail Geisingers mission to make patient care The Best.


'/>"/>

Contact: Patti Urosevich
570-271-7441
Geisinger Health System
Source:Eurekalert

Related medicine news :

1. Geisinger rheumatologists redesign osteoporosis, rheumatoid arthritis care
2. Geisinger study: PTSD a medical warning sign for long-term health problems
3. Enhanced PrecyseCode 2X(TM) Further Accelerates Remote Coding and Improves Cash Flow for Hospitals
4. Pregnancy may slow -- not accelerate -- progression to AIDS
5. Kensey Nash Reports Acceleration of Stock Awards Triggered by Shareholder Acquisition of Greater Than 20% of Outstanding Shares
6. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
7. CSHL scientist recognized for accelerating cancer gene research
8. This Holiday Season Some Dream of a White Christmas - The Accelerated Cure Project Dreams of Developing a Cure for Multiple Sclerosis
9. Sedentary Lifestyle Accelerates Aging
10. Aflac Incorporated to Accelerate Share Repurchase in 2008; Authorizes Additional Share Repurchase and Increases Quarterly Cash Dividend 17.1%
11. Accelerated head growth can predict autism before behavioral symptoms start
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Nevada (PRWEB) , ... October 13, 2017 , ... ... Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil ... required and providing a CBD form that can be easily incorporated into liquid products, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes ... of the facility as part of a disaster drill on October 3rd. , Apple ... Shelton City Emergency Manager, as well as the Connecticut Long Term Care Mutual ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... 2017 , ... Talented host, actor Rob Lowe, is introducing ... new episode of "Success Files," which is an award-winning educational program broadcasted on ... subject in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... 18, 2017 EpiVax, Inc. ("EpiVax") ... and immune engineering, today announced a new ... (H7N9) vaccine. ... influenza and presents a challenge for traditional ... to be effective. Using state-of-the-art bioinformatics and molecular ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , ... supply chains, has published the first annual edition of its Global CSR ... than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed ... ... & Performance Index ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., the ... (VLMS), is pleased to announce the appointment of ... of its Board of Directors and Chairman of ... enables life science companies to manage their entire ... of paper in this process. Furthermore, ValGenesis VLMS ...
Breaking Medicine Technology: