Navigation Links
Gaza strip families give first clue to condition causing blindness and tooth decay
Date:2/12/2009

Scientists studying an inherited condition resulting in blindness and crumbling teeth have found a single defective gene can affect both eye function and normal tooth development.

A previously undiscovered and unexpected link between the formation of teeth and eyes has been uncovered by researchers from the University of Leeds, through studies in two families living in a village in the war-torn Gaza strip.

Funded by the Wellcome Trust and Yorkshire Eye Research, the project team sought to identify the cause of a condition they named Jalili syndrome, in which related individuals suffered loss of eyesight, almost from birth, and poorly developed teeth.

Chris Inglehearn, Professor of Molecular Ophthalmology at Leeds Institute of Molecular Medicine, said: "What interested us was the idea that there might be a single process or protein essential in both teeth and eyes, not something you'd normally think of as having much in common.

"Working with colleagues in the Leeds Dental Institute, genetic changes were found that disrupt the function of a protein called CNNM4 and that are passed on from one generation to the next in these families. This protein is present in the cells that lay down tooth enamel and also in the various layers of the retina, the light sensitive 'film' at the back of the eye."

Prof Inglehearn added that little is yet known about the role of this vital protein but it is possible that it is involved in transporting magnesium or calcium to cells in the body. Both minerals are known to be important in visual function and in teeth and bone formation.

Although a rare condition, Jalili syndrome sufferers from France, Scotland, Iran, Bosnia and Guatemala were also studied. Further research could help scientists gain a better understanding of more common forms of blindness, weak teeth and bone diseases such as osteoporosis, and in time may lead to better treatments.

The possibility of usi
'/>"/>

Contact: Simon Jenkins
pressoffice@leeds.ac.uk
University of Leeds
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Neovasc Announces Agreement With LeMaitre Vascular for Exclusive Distribution Rights to its Biological Vascular Strips
2. Crest Whitestrips Introduces a Revolutionary New Teeth Whitening Technology
3. San Diego Attorney Provides Emergency Medical Relief to War Torn Gaza Strip
4. Derma Sciences Announces 3-Year Licensing Deals for Highly Profitable Character Strip Bandages
5. Protect Yourself From Teeth to Toes! Lindsay Price and Crest Whitestrips Daily Whitening + Tartar Protection Partner to Empower Women for the 9th Annual National Womens Health Week
6. Pinstripe Healthcare Group Adds Veteran HR Executive Warner as Client Services Director
7. Significant Growth for Pinstripe Leads to Need for Larger Facility
8. Novel approach strips staph of virulence
9. Shimp Joins Pinstripe as Director of Client Services for Healthcare Group
10. Rallies in Five Cities Planned on Friday the 13th to Protect CA Families From the Bad Budget Deal and Permanent, Deep Cuts to Homecare, Education, and Other Vital Services
11. American Families Unaware of Burn Dangers at Home
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... May 24, 2015 EnviroLeather™ by ... “InkGard™ Plus” – a classic, rugged leather grain ... allowing difficult stains, including ink, to be easily ... colors suitable for corporate, healthcare, hospitality and education ... with EnviroLeather’s goal of developing products that are ...
(Date:5/24/2015)... Viejo, CA (PRWEB) May 24, 2015 ProPin ... use in Final Cut Pro X. Utilize ProPin to pin ... in a given scene. , ProPin allows users to ... completely customizable in FCPX. With on-screen controls, video editors can ... allows users to pin and mark with absolute ease. , Using ...
(Date:5/24/2015)... Medicx Media Solutions http://www.medicxmedia.com ... Krihak as its head of programmatic strategy and ... expertise and leadership position in the data driven ... , Krihak is an experienced, award-winning agency and ... sales planning teams for mobile platform Jumptap. ...
(Date:5/24/2015)... 24, 2015 A report out ... the single best option for avoiding cardiovascular disease is ... level was the single most powerful predictor of death ... as diabetes and family history of premature death -- ... heart and lung fitness. , The Importance of Cardiovascular ...
(Date:5/23/2015)... D.C. (PRWEB) May 23, 2015 On ... of powers of a youngster's yogic power learned through ... Sri Nithyananda Swami in Bangalore, India. , Yogamaatha, a ... more than 50 high profile professionals attending the 2015 ... by reading fluently -- blindfolded. , In a ...
Breaking Medicine News(10 mins):Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Medicx Media Solutions Expands Executive Team 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 3Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3
... 2009, Cambridge, UK ,Anyone with a sweet tooth knows ... negative consequences. The same can be said about the ... new study of myelin, a protein key to efficient neuronal ... much like the insulation on a cable, allows for rapid ...
... nanospheres equipped with a targeting peptide find melanoma cells, penetrate ... near-infrared light, a research team led by scientists at The ... the Feb. 1 issue of Clinical Cancer Research . ... grail of therapeutic nanotechnology for cancer. We,re getting closer to ...
... Knowing what to expect before and after procedure aids healing, ... With increasing numbers of baby boomers reaching retirement age, joint ... , But improved movement and lack of pain in ... to expect from the surgery and subsequent physical therapy can ...
... Total Health Center shows that our new Hgh product destroys fat cells ... , ... (PRWEB) February 1, 2009 -- Scientists at The Total Health and ... to destroy fat on men and women without dieting. Sources at the ...
... A study in the Feb. 1 issue of the ... levels that occurs during pregnancy is more pronounced in pregnant ... , During the last trimester of pregnancy, levels ... women with RLS and 25,475 pg/mL in healthy controls. ...
... A study in the Feb. 1 issue of the ... associated with changes in the levels of specific cytokines ... suggest that inflammation may be the pathway linking extreme ... Each additional hour of self-reported sleep duration was associated ...
Cached Medicine News:Health News:Targeted nanospheres find, penetrate, then fuel burning of melanoma 2Health News:Targeted nanospheres find, penetrate, then fuel burning of melanoma 3Health News:A Checklist for Joint Replacement Surgery 2Health News:Pregnancy-related hormonal changes linked to increased risk of restless legs syndrome 2Health News:Study suggests that inflammation may be the link between extreme sleep durations and poor health 2
(Date:5/22/2015)... ROCKVILLE, Md. , May 22, 2015 /PRNewswire/ ... "RegeneRx") today announced a peer-reviewed publication of the ... study evaluating RGN-259 (RegeneRx,s preservative-free eye drops) for ... Inc.,s controlled adverse environment (CAE ® ) model.  ... and the results, which were previously disseminated by ...
(Date:5/22/2015)... 2015   InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" ... ("EPS"), today announced that its CGuard TM Embolic Prevention ... Prof. Piotr Musialek , at the EuroPCR ... . PARADIGM, an investigator-initiated P rospective ... roti D revascularization I n symptomatic and increased-risk ...
(Date:5/22/2015)... Richmond Pharmacology is a ... a worldwide reputation for excellence in clinical trials. ... peer reviewed medical journals. Its officers are engaged ... discussions about rules for transparency and publication of ... , Clinical research is conducted worldwide, ...
Breaking Medicine Technology:Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
... Milestone Scientific Inc. (OTCQB: MLSS), the recognized leader in ... its 2010 year-end results for the 12 months ended ... Commission on Wednesday, March 30, 2011. Milestone,s ... 4, 2011 beginning at 4:15 PM Eastern Daylight Savings ...
... YORK, April 1, 2011 NeoStem, Inc. (NYSE Amex: ... company with operations in the U.S. and China, is today ... activities: Revenues for the year ended December ... 2009.  2010 was the first full year that results for ...
Cached Medicine Technology:Milestone Scientific Will Host Its 2011 Conference Call on Monday, April 4, 2011 2NeoStem Provides Results for 2010 and an Update on Recent Activities 2NeoStem Provides Results for 2010 and an Update on Recent Activities 3NeoStem Provides Results for 2010 and an Update on Recent Activities 4NeoStem Provides Results for 2010 and an Update on Recent Activities 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: