Navigation Links
Gauging Brain Cancer Survival Time May Get Easier: Study
Date:4/10/2013

WEDNESDAY, April 10 (HealthDay News) -- Life expectancy of people with aggressive brain cancer may be easier to determine with a new method under development at the University of Alabama at Birmingham, researchers say.

The UAB researchers found that patients with an overactive version of a specific enzyme live less than half as long as those with a less active version. This overactive enzyme can help predict how resistant the brain cancer will be to chemotherapy, and also help doctors arrive at treatment recommendations, the researchers said.

In conducting the study, published April 10 in the journal PLoS ONE, the researchers examined tumors from 84 patients with a form of brain cancer known as glioblastoma multiforme (GBM). This deadly and aggressive cancer quickly becomes resistant to available treatments. With a combination of surgery, radiation and the chemotherapy drug temozolomide, patients with this form of brain cancer typically survive an average of 12 to 15 months.

The study revealed, however, that 25 percent to 30 percent of the patients whose tumor cells had an overactive version of an enzyme known as cytochrome c oxidase (CcO) live less than half as long as patients with a less active version.

"Our study reports for the first time the role of [CcO] as a prognostic marker in GBM patients' tumor tissues," study leader Corinne Griguer, an associate professor of neurosurgery in the UAB School of Medicine, said in a university news release. "High CcO activity comes with a 25-fold increase in risk of death."

The researchers said patients with the overactive enzyme lived for an average of six months. Those with a less active version lived for 14 months. Examination of a second group of glioblastoma multiforme patients from Europe confirmed their findings, the researchers said.

They concluded that tumor cells with increased CcO activity generate more energy and are more resistant to chemotherapy. The overactive enzyme also interferes with a protein, called cytochrome c, that triggers the self-destruction of cells infected or damaged by diseases such as cancer. When this happens, cancer cells can survive an abnormally long time.

But the researchers aren't stopping with this finding. "Giving some GBM patients bad news about their prognoses without also giving them better treatment options doesn't seem right to me," said Griguer, noting that the team is experimenting with another enzyme to try to predict patients' survival benefit from the chemo drug temozolomide.

"Our ultimate goal is to use the same mechanism that predicts shorter survival in some to design drugs that target cells not killed right away by chemotherapy," she said.

More information

The U.S. National Institutes of Health provides more information on brain cancer.

-- Mary Elizabeth Dallas

SOURCE: University of Alabama at Birmingham, news release, April 10, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gauging seizures severity
2. For First Time, Pain Signature Spotted on Brain MRIs
3. Brain Surgery Eases Compulsive Eating in 10-Year-Old Girl
4. A New Peer-Reviewed Study Using CogniFit Brain Training Provides A Breakthrough In The Treatment Of Insomnia
5. RI Hospital: Traumatic brain injury worsens outcomes for those with nonepileptic seizures
6. Extracellular vesicles may open new opportunities for brain cancer diagnosis and treatment
7. Non-invasive mapping helps to localize language centers before brain surgery
8. Scans May Reveal Pre-Schizophrenia Brain Changes
9. Sexuality, traumatic brain injury, and rehabilitation
10. New minimally invasive, MRI-guided laser treatment for brain tumor found to be promising in study
11. Voices Against Brain Cancer Responds to Research Identifying Contributing Factor in Brain Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gauging Brain Cancer Survival Time May Get Easier: Study
(Date:2/5/2016)... , ... February 05, 2016 , ... Looking for a ... be at the tips of your toes. Foot massage, whether administered by a professional ... comfort and relaxation. The American Board of Multiple Specialties in Podiatry (ABMSP) ...
(Date:2/5/2016)... ... 05, 2016 , ... US Sports Camps , official operators of Nike ... high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in the picturesque New ... ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled to be ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure today ... for and donate to Give To Cure’s campaign that is crowdfunding clinical trials to ... make and share payments through a smart device. In 2015 alone, Venmo processed $7.5 ...
(Date:2/5/2016)... ... 2016 , ... Dr. Justin Scott and Dr. Lydia Muccioli of Pure ... to individuals in need. The event is scheduled to take place on February 27, ... to provide dental care to community members in need. Each patient will be given ...
(Date:2/5/2016)... ... ... In sleep, when the defenses of the day are at rest, rejected ... eating disorders is significant self-criticism, and consequently these patients experience this disease with their ... means for coping with this unease, but also leads to a reservoir of emotions ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)...  Montoya Love is recognized by Continental Who,s Who ... Montoya is the Regulatory Systems Operations Manager with ... Manufacturing and selling a broad range of ... healthcare institutions, clinical laboratories and life science researchers with ... globe. ...
(Date:2/4/2016)... 2016 Frontier Pharma: Chronic Obstructive Pulmonary ... Chronic Obstructive Pulmonary Disease (COPD) ... of the airways and lungs. Persistent breathing difficulties ... disease one of the leading causes of morbidity ... world. COPD is linked to cumulative exposure to ...
(Date:2/4/2016)... Medical, Inc. (Nasdaq: AEMD ), the pioneer ... diseases, today announced results for the third quarter ... --> --> "Beyond ... quarterly call, we strategically advanced pre-clinical and clinical ... the Aethlon Hemopurifier® as a leading broad-spectrum countermeasure ...
Breaking Medicine Technology: