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Gateway enzyme for chemicals from catnip to cancer drug
Date:11/21/2012

Scientists have discovered an enzyme used in nature to make powerful chemicals from catnip to a cancer drug, vinblastine. The discovery opens up the prospect of producing these chemicals cheaply and efficiently.

They are produced naturally by some plants such as the medicinal Madagascar periwinkle, but faster-growing plants could be used to produce them. With synthetic biology, improvements could also be made to them.

The study, to be published in Nature on Thursday, was led by scientists from the John Innes Centre, an institute on Norwich Research Park strategically funded by BBSRC.

"Thousands of chemicals are derived from the enzyme we have called iridoid synthase," says senior author Dr Sarah O'Connor from the JIC and the University of East Anglia.

"We can start to use it to come up with new-to-nature structures with biological activity of benefit to both medicine and agriculture."

Many aphids, often important agricultural pests, produce sex pheromone chemicals that are identical to or that closely resemble the iridoid synthase product. Strategic use of these iridoid chemicals could be used to disrupt the aphids' breeding cycle or to repel them from crops.

The anticancer ingredient vinblastine sulphate is currently derived from the Madagascar periwinkle plant. The iridoid synthase is an essential step in the production of this compound. But vinblastine is produced in just very low levels and the drug has many side effects. The hope is to find a way to produce it more cheaply, easily and with a chemical structure that lessens side effects.

"We need to identify more enzymes to see the entire pathway used in nature to make this potent compound," said Dr O'Connor.

"But the enzyme we have discovered is also the basic scaffold for many other iridoid chemicals and we can start to experiment with building new chemical structures with biological activity."

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Contact: Zoe Dunford
zoe.dunford@nbi.ac.uk
44-016-032-55111
Norwich BioScience Institutes
Source:Eurekalert  

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