Navigation Links
Gastric bypass findings could lead to diabetes treatment
Date:5/1/2013

A Lund University research team has shed new light on why gastric bypass often sends diabetes into remission rapidly, opening the door to developing treatment with the same effect.

85% of patients with type 2 diabetes who undergo a gastric bypass procedure recover from the disease within a few days, showing a return to normal blood sugar levels - long before any weight loss. Until now, there have been few clues as to why this happens.

"Most previous studies have analysed samples taken from patients before and after a gastric bypass, but there is a risk that the results are misleading. They may not be attributable to the operation itself, but rather to factors such as weight loss and reduced food intake", says Nils Wierup of the Lund University Diabetes Centre in Sweden.

In a gastric bypass, food bypasses the majority of the stomach and duodenum. Just a small part of the upper stomach is connected directly to the small intestine. In some cases, the surgeon inserts a catheter into the part of the stomach that no longer has contact with food as a precautionary measure. This was what gave the researchers an opportunity to study the exact difference between food intake before and after the procedure.

The participants were given a set amount of a nutritional drink and blood samples were taken before, during and at short intervals after it was drunk. The next step was to inject the same amount of nutritional solution through the catheter over the same length of time as it had taken the patient to drink it and the same samples were taken. The food then ended up where it would have been before the gastric bypass.

The comparison revealed a major difference.

"When the patient drank the solution, the insulin levels in the blood rose almost five times as much as when it was injected into the closed-off stomach. Intestinal hormones, which play a significant role in controlling blood sugar levels, rose sharply, as did certain amino acids. There was also a major impact on blood lipids, with the levels roughly halved", says Nils Wierup, observing:

"We believe these changes are part of the answer to why gastric bypass cures type 2 diabetes. We have looked at just a few intestinal hormones. There may be a hundred or more involved in the body's complex sugar metabolism."

Jan Hedenbro, one of the surgeons in the study, adds: "If we can identify the mechanism behind this, it will open the way for both more individually tailored operations and, in the long run, the possibility of achieving the same results with pills rather than with surgery."


'/>"/>

Contact: Nils Wierup
Nils.Wierup@med.lu.se
46-703-786-624
Lund University
Source:Eurekalert

Related medicine news :

1. Additional imaging gives better view and reduces complications in patients needing gastric tubes
2. Gut Bacteria May Be Key to Gastric Bypass Effects: Study
3. Surgery and radiation improve survival for metastatic gastric cancer patients, Moffitt study shows
4. Study identifies factors associated with eradication of bacteria linked to gastric cancer
5. Collaboration and innovation win CWRU School of Medicine grant to study gastric cancer
6. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
7. Gastric banding an effective long-term solution to obesity
8. Gastric Bypass Supplements Redesigns Their Leading Website
9. Gastric bypass surgery helps diabetes but doesnt cure it
10. Moveable Magnets Used to Forge Gastric Bypass in Pigs
11. Gastric feeding tubes may raise pressure ulcer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
Breaking Medicine Technology: