Navigation Links
Garlic oil component may form treatment to protect heart
Date:11/16/2011

A component of garlic oil may help release protective compounds to the heart after heart attack, during cardiac surgery, or as a treatment for heart failure.

At low concentrations, hydrogen sulfide gas has been found to protect the heart from damage. However, this unstable and volatile compound has been difficult to deliver as therapy.

Now researchers at Emory University School of Medicine have turned to diallyl trisulfide, a garlic oil component, as a way to deliver the benefits of hydrogen sulfide to the heart. Their findings suggest that doctors could use diallyl trisulfide in many of the situations where researchers have proposed using hydrogen sulfide.

The data are being presented Wednesday, Nov. 16 at the American Heart Association (AHA) Scientific Sessions conference in Orlando.

"We are now performing studies with orally active drugs that release hydrogen sulfide," says David Lefer, PhD, professor of surgery at Emory University School of Medicine and director of the Cardiothoracic Surgery Research Laboratory at Emory University Hospital, Midtown. "This could avoid the need to inject sulfide-delivery drugs outside of an emergency situation."

Working with Lefer, postdoctoral fellow Benjamin Predmore blocked the coronary arteries of mice for 45 minutes, simulating a heart attack, and gave them diallyl sulfide just before blood flow was restored. The compound reduced the proportion of damaged heart tissue in the area at risk by 61 percent, compared with untreated animals.

"Interruption of oxygen and blood flow damages mitochondria, and loss of mitochondrial integrity can lead to cell death," he says. "We see that diallyl sulfide can temporarily turn down the function of mitochondria, preserving them and lowering the production of reactive oxygen species."

Additional data on diallyl trisulfide in a mouse model of heart failure is being presented by a member of Lefer's team, postdoctoral fellow Kazuhisa Kondo Wednesday at 11:30 a.m.

Transverse aortic constriction results in enlargement of the heart and is a model of heart failure. Diallyl sulfide twice daily, given after aortic constriction, could reduce heart enlargement, Kondo found.

Also at the meeting, Lefer's team is presenting additional data on mice deficient in the enzyme that generates hydrogen sulfide.


'/>"/>

Contact: Jennifer Johnson
jrjohn9@emory.edu
404-727-5696
Emory University
Source:Eurekalert

Related medicine news :

1. New testing method hints at garlics cancer-fighting potential
2. Marijuana component could ease pain from chemotherapy drugs
3. Researchers identify components that keep immune system in check
4. Indirubin -- Component Of Chinese herbal remedy might block brain tumors spread
5. Satisfaction with the components of everyday life appears protective against heart disease
6. Researchers identify components of speech recognition pathway in humans
7. Scientists identify key component in lethal lung cancer complication
8. Cells talk more in areas Alzheimers hits first, boosting plaque component
9. Financial planning a key but neglected component of Alzheimers care, say researchers
10. Louisiana State University Health Sciences Center research shows fish oil component given up to 5 hours after stroke limits brain damage
11. Researchers create first molecule blocks key component of cancer genes on-off switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2017)... ... May 26, 2017 , ... A May 8 ... a doctor for colds or respiratory issues that are not responsive to antibiotics nevertheless ... on doctors may be largely responsible for the problem both in Canada and the ...
(Date:5/26/2017)... ... May 26, 2017 , ... Mediaplanet is proud to ... campaign in USA Today, which will educate readers on how to take care of ... a large focus is placed on melanoma. Dancing with the Stars professional, Witney Carson, ...
(Date:5/26/2017)... Calif. (PRWEB) , ... May 26, 2017 , ... ... the integration of the CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep ... a consistent, browser-based interface for diagnostic device operations. With this platform, initializing devices ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... After raising ... Antzy Top gadget will continue to be available at a discounted crowdfunding price on ... with stress wherever they are, I also wanted to bring a fidget toy to ...
(Date:5/26/2017)... ... May 26, 2017 , ... “When the Stars Lead Home”: a poignant ... of published author Laura Weigel Douglas, an avid reader who lives in the Pacific ... sometimes feels like Green Hills Adventure Camp. She couldn’t be more grateful. , Twelve-year ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
(Date:5/3/2017)... Calif. , May 3, 2017 ... of any hospital or healthcare facility. Commonly referred ... room is equipped with diagnostic imaging technology to ... of the heart. In these spaces, a team ... catheterization, balloon angioplasty, percutaneous coronary intervention, congenital heart ...
(Date:5/3/2017)... N.J. , May 3, 2017  Getinge, ... that contribute to quality enhancement and cost efficiency ... from a study of contemporary practice demonstrating that ... first-line therapy for critically ill patients. The single-center, ... Company,s newer large volume MEGA ® 50cc ...
Breaking Medicine Technology: